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Application of correlation techniques in the analysis of corpus cavernosum electromyographic signals

Asian Journal of Andrology 2007年第3期9卷 369-376页

作者： Xiao-Gang Jiang Jan Holsheimer Ljubomir Manola Gorm Wagner Hessel Wijkstra Ben Knipscheer Eric J. H. Meuleman Department of Urology Radboud University Nijmegen Medical Centre 6500 HB Nijmegen the Netherlands Institute for Biomedical Technology University of Twente 7500 AE Enschede the Netherlands Institute of Preventive Medicine Copenhagen University Hospital DK-1375 Copenhagen Denmark Department of Urology Academic Medical Centre 1105 AZ Amsterdam the Netherlands Department of Urology Free University Medical Centre 1007 MB Amsterdam the Netherlands

Aim： To establish an objective, easy-to-use and comprehensive method to analyze corpus cavernosum electromyo- graphic signals （CC-potentials）. Methods： CC-potentials were recorded during flaccidity in 23 young healthy volunteers, with surface electrodes placed on the penile shaft bilaterally. Based on the correlation function of Matlab software, an application program for the analysis of CC-potentials was developed. Individual CC-potentials and their autocorrelation function were evaluated, yielding parameters amplitude （A）, duration （D）, and dominant frequency （DF）. The crosscorrelation function of both longitudinal and bilateral pairs of adjacent electrodes was calculated to assess the similar- ity and mutual delay of CC-potentials recorded simultaneously from different parts of the CC. The parameters derived were squared maximum cross-correlation coefficient （Rmax） and delay （τ）. Based on the absolute value of τ and the corresponding inter-electrode distance, propagation velocity （PV） was calculated. Results. The values of the parameters were determined automatically. No significant difference related to the locations of the electrodes for parameters A, D, and DF was detected. The cross-correlation showed that both longitudinal and bilateral CC-potential pairs had highly similar waveforms （the absolute values of Rmax were 0.80 ± 0.05 and 0.87 ± 0.06, respectively）. PV of longitudinal pairs was estimated as 6.15 ± 3.98 cm/s. Conclusion： The application program for correlation analysis of CC-potentials is a comprehensive and versatile method to analyze corpus cavernosum electromyographic recordings. Its objectiveness makes multi-center application possible.

关键词： corpus cavernosum corpus cavernosum electromyography electrophysiology erectile dysfunction smooth muscle

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Effects of tetrandrine on cytosolic free calcium concentration in corpus cavernosum smooth muscle cells of rabbits

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Asian Journal of Andrology 2006年第4期8卷 405-409,513-514页

作者： Ji-Hong Liu Jun Chen Tao Wang Bo Liu Jun Yang Xiao-Wen Chen Shao-Gang Wang Chun-Ping Yin Zhang-Qun Ye Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Aim:To study the relaxation mechanisms of tetrandrine(Tet)on the corpus cavernosum smooth ***: The corpus cavernosum smooth muscle cells from New Zealand white rabbits were cultured in vitro.[Ca^(2+)]_i was measured by Fluorescence Ion Digital Imaging System,using Fluo-2/AM as a Ca^(2+)-sensitive fluorescent indicator. Results:Tet(1,10 and 100 μmol/L)had no effect on the resting [Ca^(2+)]_i(P>0.05).In the presence of extracellular Ca^(2+)(2.5 mmol/L),Tet(1,10 and 100 μmol/L)inhibited [Ca^(2+)]_i elevation induced by high K^+ and phenylephrine(PE) in a concentration-dependent manner(P0.05).However,Tet(100μmol/L)inhibited [Ca^(2+)]_i elevation induced by PE(Pcorpus cavernosum smooth muscle *** inhibitory action on [Ca^(2+)]_i might be one of the relaxation mechanisms of Tet on the corpus cavernosum smooth muscle.(Asian J Androl 2006 Jul;8:405-409)

关键词： tetrandrine penis smooth muscle cell free calcium corpus cavernosum erectile dysfunction

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Three-dimensional mapping and comparative analysis of the distal human corpus cavernosum and the inflatable penile prosthesis

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Asian Journal of Andrology 2013年第4期15卷 567-570,I0012页

作者： Tariq S Hakky Daniel Ferguson Philippe E Spiess Paul Bradley Tom FLue Rafael E Carrion Department of Urology University of South Florida Tampa General Circle Tampa FL 33602 USA 23D3Solutions Burnaby BCV5J 5M8 Canada and Department of Urology University of Southern California San Francisco 400 Parnassus Ave San Francisco CA 94143 USA

The intricate anatomy of the corpus cavernosum in both the flaccid and tumescent state has not been fully elucidated. We report our experience using a three-dimensional （3D） scanner to reconstruct cadaveric casts and compare them with 3D images of two prototypes of penile prosthesis. Two different models of the Titan Coloplast inflatable penile prosthesis were analyzed using a 3D scanner. The first was the standard model and the second was a newer model with a rounder silicone tip. Two cadaveric phalluses were harvested using Smooth-Cast 300Q polyurethane molding. The molds were excised and scanned along side the penile prosthesis. 3D scans were completed and analyzed using Leios Mesh software, and GOM Inspect software. The 3D scans demonstrated the mean human corporal radii 2 mm from the distal tip to be 36.51 mm （36.01-37.0 mm）, which is an obtuse angle. The standard Titan penile prosthesis spherical radius at the same level was 202.52 mm, while the new silicone tip prosthesis had a radius of 139.33 mm. 3D mapping further demonstrated the trajectory of the cavernosa appeared curvilinear and the distal ends appeared blunt. The use of cadaveric cavernosal molds in combination with the 3D scanner allowed us to accurately image the corpus cavernosum for the first time. Our findings suggest that anatomically accurate corporal tips appear to be relatively blunt and that the new Titan silicone tip penile prosthesis more closely resembles the human corporal tip.

关键词： corpus cavernosum penile prosthesis three-dimensional analysis

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Effect of sodium nitroprusside on hemodynamics of corpus cavernosum in Chinese

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Asian Journal of Andrology 2001年第4期3卷 311-313页

作者： Qiang FU De-Hong YAO Yue-Qing JIANG Department of Urology,Shanghai Ninth People’s Hospital,Shanghai Second Medical University,Shanghai 200011,China Department of Urology Shanghai Ninth People's Hospital Shanghai Second Medical University China. jamesqfu@***

Aim: To study the effect of sodium nitroprusside (SNP) on the hemodynamics of corpus cavemosum in Chinese menwith erectile dysfunction (ED). Methods; In 68 ED patients receiving intracavemous injection (ICI) of SNP, thecavernous hemodynamics were studied by Doppler ultrasonography. Results: The peak flow velocity (PFV), theartery diameter (Ad), the mean velocity of arterial blood (MV) and the vein diameter (Vd) were significantly higherafter ICI of SNP than before ICI, but the end diastolic velocity (EDV) did not change significantly. Conclusion;The increase in Vd after SNP suggests that the venous outflow is not invariably decreased during penile erection.(Asian J Androl 2001 Dec; 3: 311 - 313)

关键词： hemodynamics corpus cavernosum nitric oxide Doppler ultrasonography erectile dysfunction

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Effects of buried penis on the structure and function of corpus cavernosum in a rat model

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Chinese Medical Journal 2010年第13期123卷 1736-1740页

作者： CHENG Fan YU Wei-min XIA Yue ZHANG Xiao-bin YANG Si-xing GE Ming-huan Department of Urology Renmin Hospital of Wuhan University Wuhan Hubei 430060 China

Background While the abnormal appearance of the concealed penis has been well recognized, the effect of buried penis on the structure and function of corpus cavernosum has not been well studied. To explore this issue, we established a rat model and evaluated the effect of buried penis on cavernosum weight, contents and ultrastructure of tissue, and nitric oxide synthase （NOS） activity. Methods Two hundred and ten rats were randomly divided into 3 equal cohorts for 2, 4 and 6 months study （groups A, B and C）. Each group was randomly divided into buried group （n=40）, control group （n=15）, and normal group （n=15）, respectively. Intra-purse-string suture of the root of the penis was used to establish the model. Macroscopic development was judged by measuring the weight of the corpus cavernosum. Masson＇s trichrome staining was performed for observing microstructure while a transmission electron microscope was used for observing ultrastructure. The NOS activity was detected by a NOS activity assay kit. Results Buried penis had no significant influence on the appearance and weight of the corpus cavernosum. Buried penis resulted in decreased smooth muscle content （P 〉0.05 in group A, and P 〈0.05 in groups B and C） and increased fibrous connective tissue content （P 〉0.05 in groups A and B, and P 〈0.05 in group C） compared with the normal and control groups. Ultrastructural abnormalities of corpus cavernosum were observed in the 6-month buried group. Moreover, there was decrease of NOS activity in groups B and C （P 〈0.05 in group B and P 〈0.01 in group C） when compared with the normal and control groups. Conclusion Buried penis affects the structure and function of corpus cavernosum in rats and the effect is positively correlated with the buried time, but there is no significant effect on the macroscopic development.

关键词： buried penis corpus cavernosum structure function

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Quantitative assessment of the aging corpus cavernosum by shear wave elastography

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Asian Journal of Andrology 2022年第6期24卷 628-632页

作者： Hao Cheng Guo-Xiong Liu Fei Wang Ke Wang Li-Tao Ruan Lin Yang Department of Ulitrasonography First Affiliated Hospital of Xian Jiaotong UniversityXi'an 710061China Department of Ultrasonography Shaanxi Province Cancer HospitalXi'an 710061China Department of Urology First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China

We wanted to determine whether shear wave elastography(SwE)could be used to evaluate the aging degree of the corpus cavernosum(CC)and to identify the histological basis of changes in SWE measurements during the aging *** performed a crosssectional study enrolling healthy participants of different *** measured the Young's modulus(YM)of the penile CCs by SWE and assessed erectile function using the International Index of Erectile Function-5(IIEF-5).Histological investigation was performed in surgically resected penile specimens from a separate group of patients to examine the smooth muscle and collagen content of the ***,we measured the YM,erectile function,smooth muscle,and collagen content of the CCs in different age groups of ***,we enrolled 210 male volunteers in this *** YM of the CC(CCYM)was positively correlated with age(r=0.949,P<0.01)and negatively correlated with erectile function(r=-0.843,P<0.01).Histological examinations showed that cCs had increased collagen content but decreased smooth muscle content with increased *** same positive correlation between CcYM and age was also observed in the animal *** addition,the animal study showed that older rats,with increased CcYM and decreased erectile function,had lower smooth muscle content and higher collagen *** can noninvasively and quantitatively evaluate the aging degree of the *** collagen content and decreased smooth muscle content might be the histological basis for the effect of aging on the CC and the increase in its YM.

关键词： aging collagen corpus cavernosum erectile dysfunction shear wave elastography smooth muscle

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Antioxidant properties of berberine on cultured rabbit corpus cavernosum smooth muscle cells injured by hydrogen peroxide

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Acta Pharmacologica Sinica 2007年第12期28卷 1914-1918页

作者： Yan TAN~(2,3,5),Qiang TANG~4,Ben-rong HU~4,Ji-zhou XIANG~4~2 Institute of Urology,Renmin Hospital,Yunyang Medical College,Shiyan 442000 China,~3 Department of Pharmacology,Yunyang MedicalCollege,Shiyan 442000,China,~4 Department of Pharmacology,Tongji Medical College,Huazhong University of Science and Teehnology,Wuhan 430030,China InstituteofUrology RenminHospitalYunyangMedicalCollegeShiyan442000China DepartmentofPharmacology YunyangMedicalCollegeShiyan442000China TongjiMedicalCollege HuazhongUniversityofScienceandTechnologyWuhan430030

Aim:To investigate the antioxidant properties of berberine (Ber) on corpuscavenosum smooth muscle cells (CCSMC) in penile erectile ***:We examined the effects of Ber on cultured rabbit CCSMC damaged by hydrogenperoxide (H2O2) through examining cell viability by methyl thiazolyl tetrazoliumassay and assessing the level of malondialdehyde (MDA),superoxide dismutase,(SOD) activity,nitric oxide (NO) products,and lactate dehydrogenase (LDH) re-lease in cells after stimulation with ***:Treatment with 1 mmol/L H2O2significantly decreased the cell viability,NO products,and SOD activity of CCSMCfrom 100% to 48.57%±4.1% (P<0.01),66.8±16.3 to 6.7±2.1 μmol/L (P<0.01),and49.5±1.8 to 30.1±2.6 U/mL (P<0.01),respectively,and increased LDH release andMDA content from 497.6±69.5 to 1100.5±56.3 U/L (P<0.01) and 3.7±1.3 to 78.4±2.9nmol/mg protein (P<0.01),***,treatment with different con-centrations of Ber (10-1000 μmol/L) inhibited the damaging effects of H2O2,withincreased cell viability (P<0.05 or P<0.01),NO production (P<0.01),and SODactivity (P<0.01) and decreased LDH release and MDA content (both P<0.01).Conclusion:Bet could produce its antioxidant action on oxidative stress-inducedcultured *** effects may be of benefit in the prevention of penileerectile dysfunction.

关键词： berberine antioxidant action corpus cavernosum erectile dysfunction

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Testosterone replacement maintains smooth muscle content in the corpus cavernosum of orchiectomized rats

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Asian Journal of Urology 2017年第4期4卷 223-229页

作者： Graziele Halmenschlager Ernani Luis Rhoden Gabriela Almeida Motta Lucas Sagrillo Fagundes Jorge Luiz Medeiros Jr Rosalva Meurer Claudia Ramos Rhoden Centro Universitario Ritter dos Reis(UniRitter)and Universidade Federal de Cieˆncias da Sau´de de Porto Alegre(UFCSPA)e PPG Cieˆncias da Sau´de Porto AlegreRSBrazil Department of Urology at Universidade Federal de Cieˆncias da Sau´de de Porto Alegre(UFCSPA) Urologist at Irmandade Santa Casa de Miserico´rdia de Porto Alegre(ISCMPA)and Hospital Moinhos de Vento de Porto Alegre(HMV)Porto AlegreRSBrazil Universidade Federal de Cieˆncias da Sau´de de Porto Alegre(UFCSPA)e PPG Cieˆncias da Sau´de-Porto Alegre RSBrazil INRS Institut Armand Frappier(Universit.du Que´bec)and BioMed Research Center Laval QuebecCanada Laboratory of Morphometry Metabolismand Cardiovascular DiseaseBiomedical CenterInstitute of BiologyState University of Rio de JaneiroRio de JaneiroBrazil Laboratory of Multidisciplinary of Sciences Biomedical CenterMedical School of Valenc¸aValenc¸a/Rio de JaneiroBrazil

Objective:To evaluate the effects of testosterone(T)on the maintenance of corpus cavernosum(CC)structure and ***:Animals were divided into three groups:sham operation group(n Z 8)underwent sham operation;Orchiectomized(Orchiec)t oily vehicle group(n Z 8)underwent bilateral orchiectomy and received a single dose of oily vehicle by intramuscular injection(i.m.)30 days after orchiectomy;and Orchiec t T group(n Z 8)underwent bilateral orchiectomy and received a single dose of T undecanoate 100 mg/kg i.m.30 days after the *** were euthanized 60 days after the beginning of the experiment with an anesthetic overdose of ketamine and *** samples and penile tissue were collected on euthanasia.

关键词： Testosterone replacement Histomorphometry Androgen deprivation Hypogonadism corpus cavernosum

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Effects of Ligustrazine on the Contraction of Isolated Rabbit corpus cavernosum Strips

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2005年第5期25卷 565-567页

作者：肖恒军刘继红尹春萍王涛陈俊樊龙昌叶章群 Department of Urology Tongji HospitalHuazhong University of Science and Technology Wuhan 430030 China Department of Pharmacology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Summary： To investigate the role of ligustrazine on relaxation of the isolated rabbit corpus cavernosum tissue in vitro, the effects of ligustrazine on the corpus cavernosum were observed by using experimental method of smooth muscle strips. Concentration-responses to phenylephine （PE） and KCI were recorded. The results showed that ligustrazine concentration-dependently depressed the contraction response of smooth muscle strips induced by PE. The maximum percentage relaxation of cavernosal strips by ligustrazine was 74.1±6.2 % （compared with control： 21.9±5.6%, P〈0.01）. Ligustrazine concentration-dependently reduced the amplitude of the contraction induced by cumulative doses of PE or KCI, shifted the cumulative concentration response curves of PE and KCI to the right and depressed their maximal responses. It was concluded that ligustrazine could significantly relax the cavernosal muscle contraction induced by PE in vitro. The results suggested that ligustrazine inhibited calcium ion influx.

关键词： ligustrazine corpus cavernosum calcium channel concentration

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Effect of Berberine on the mRNA Expression of Nitric Oxide Synthase(NOS) in Rat corpus cavernosum

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2005年第2期25卷 127-130页

作者：谭艳明章银汤强蒋兆键胡本容向继洲 DepartmentofPharmacology SchoolofBasicMedicalSciencesTongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan430030China DepartmentofPharmacology SchoolofBasicMedicalSciencesTongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan430030China

Summary: In order to further investigate the mechanisms of action of berberine (Ber), we assessed the effects of Ber on the mRNA expression of nitric oxide synthases (NOS) in rat corpus cavernosum. After incubation with Ber for 1 or 3 h respectively, the levels of NOS mRNA were examined by reverse transcription polymerase chain reaction (RT-PCR). Our results showed that there were iNOS and eNOS mRNA expressions in rat corpus cavernosum. Ber enhanced eNOS mRNA expression in rat penis, but exhibited no effect on the expression of iNOS mRNA (P>0.05). The present study indicated that the relaxation of Ber involved the NO-cGMP signal thansduction pathway. The enhancing effect of Ber on eNOS mRNA expression might associated with its relaxation of corpus cavernosum.

关键词： berberine nitric oxide synthase nitric oxide corpus cavernosum erectile dysfunction

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