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The efficacy and safety of besifloxacin for acute bacterial conjunctivitis: a Meta-analysis

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 1027-1036页

作者： Jun-Jie Wang Xin-Yi Gao Hong-Zhuo Li Shan-Shuang Du Changzhi Medical College Changzhi 046000Shanxi ProvinceChina Shaanxi Ophthalmic Medical Center Xi’an No.4 HospitalAffiliated Guangren HospitalSchool of MedicineXi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Heping Hospital Affiliated to Changzhi Medical College Changzhi 046000Shanxi ProvinceChina

AIM: To evaluate the relative efficacy and safety of besifloxacin for treatment of acute bacterial ***: A comprehensive search in PubMed, EMBASE Web of Science, Cochrane Central Database and CNKI was undertaken for randomized controlled trials(RCTs) comparing besifloxacin with other treatments or placebo. The primary outcome measures were clinical resolution, rates of bacterial eradication, individual clinical outcomes, cure rates, and bacterial eradication rates of different kinds of pathogens. Safety outcomes were the number of adverse effects(AEs). The final search was performed on August ***: Eight RCTs were included. Five studies compared the efficacy and safety of besifloxacin with placebo, 2 studies compared besifloxacin with moxifloxacin, and 1 study compared besifloxacin with gatifloxacin. A total of 3105 patients met the inclusion criteria. Besifloxacin presented higher efficacy and safety than did placebo in clinical resolution, rates of bacterial eradication, individual clinical outcomes, cure rates, bacterial eradication rates of different kinds of pathogens and the number of AEs. There was no significant difference between besifloxacin and moxifloxacin or gatifloxacin in the comparison items mentioned ***: Besifloxacin is highly effective and safe for treatment of acute bacterial conjunctivitis. Further comparative trials regarding the effect of besifloxacin for treatment of acute bacterial conjunctivitis will aid in treatment decisions.

关键词： besifloxacin acute bacterial conjunctivitis Meta-analysis randomized controlled trials

A Case of Serratia marcescens conjunctivitis in a Young Male after Exposure to Contaminated Shampoo in a Fitness Club

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Open Journal of Ophthalmology 2023年第2期13卷 233-237页

作者： Muhammad Abdulrahman Halwani Faculty of Medicine Department of Medical Microbiology Al Baha University Al Baha Saudi Arabia

The contamination of shampoo with bacteria is not very common but can happen and can be a potential cause of conjunctivitis. This case report describes a 24-year-old male who developed conjunctivitis after using a Serratia marcescens contaminated shampoo in a fitness club. The patient had redness, swelling, and discharge in both eyes. Cultures of the shampoo and eye swabs were positive for S. marcescens with indistinguishable DNA fingerprints. The patient was treated with an eye drop antibiotic and his symptoms resolved within a week. This case highlights the possibility of exposure in places where shampoos containers are refilled or shared. The avoidance of refilling them and using replaceable cartridges, single-sealed refill bags, or bringing personal shampoo is highly recommended to prevent such incidents.

关键词： Serratia Marcescens conjunctivitis Contaminated Shampoo Eye Swabs

Coagulase-negative Staphylococci in conjunctivitis and Blepharitis

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眼科学报 1993年第3期9卷 129-135页

作者： Yue-Kong Au Harold GJensen James Rowsey Mark Reynolds Department of Ophthalmology Louisiana State UniversityShreveportLouisianaUSA Dean McGee Eye Institute Oklahoma CityOklahomaUSA

Coagulase-negative staphylococcus(C-NS)are regarded as normal flora of the lids and *** ability of these organisms to cause conjunctivitis and blepharitis can be overlooked or *** elucidate the role of individual C-NS species in these eye diseases we compared Staphylococcus *** from the conjunctiva and lids of 50 healthy volunteers with 248 strains of Staphylococcus isolated from patients with staphylococcal conjunctivitis or *** was the most frequent species isolated from the conjunctiva and lids of both *** was isolated only from infected *** individual C-NS species was found to be significantly associated with eye disease,but the colony count of C-NS after isolation was a useful indicator of conjunctivitis and *** ability of Staphylococcus to ferment mannitol or mannose was associated with isolates only from infected patients.

关键词： Staphylococcus aureus coagulase-negative Staphylococcus Staphylococcus epidermidis conjunctivitis blepharitis

Can omalizumab be used effectively to treat severe conjunctivitis in children with asthma?A case example and review of the literature

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World Journal of Clinical Pediatrics 2021年第4期10卷 48-52页

作者： Stephen Doherty Melissa Mulholland Michael Shields Patrick McCrossan Department of Paediatrics Royal Belfast Hospital for Sick ChildrenBelfast BT126BAUnited Kingdom Department of Paediatric Education and Simulation Royal Belfast Hospital for Sick ChildrenBelfast BT126BAUnited Kingdom Department of Child Health Queens University BelfastBelfast BT126BJUnited Kingdom Centre of Medical Education Queens University BelfastSchool of MedicineBelfast BT97BLUnited Kingdom Department of Paediatric Respiratory Royal Belfast Hospital for Sick ChildrenBelfast BT126BAUnited Kingdom

A 14-year-old girl with poorly controlled asthma attended the difficult-to-treat asthma clinic for *** she has eosinophilia and significantly raised immunoglobulin E levels,she is not currently a candidate for omalizumab(Xolair).She also suffers from chronic urticaria,eosinophilic eosophagitis and severe *** wonder if omalizumab would be effective in treating her multiple atopic conditions,in particular her troublesome *** was searched using the following search terms:(Omalizumab)or(Xolair)and(conjunctivitis).Searches were conducted in November *** were selected for full text review if the study population identified asthma as a ***-paediatric studies and those that were not written in English were *** use of omalizumab has the potential to be effective in the treatment of conjunctivitis associated with asthma and other atopic ***,research is needed to address the question,in the form of multicenter,double-blind randomized control trials.

关键词： Omalizumab conjunctivitis Allergy Asthma Pediatrics Atopy

CLINICAL REPORT ON 142 CASES (278 EYES) OF AFRICAN EPIDEMIC HEMORRHAGIC conjunctivitis TREATED WITH ACUPUNCTURE

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World Journal of Acupuncture-Moxibustion 1994年第2期4卷 19-23页

This paper introduces the curative effects on 142 cases (278 eyes) of African epi-demic hemorrhagic conjunctivitis treated by acupuncture, and 128 (90. 1%) cases (250 eyes) of allpatients have been improved. Three groups were clinically observed in the present report. There were55 cases (104 eyes) in the first group for body acupuncture, of which 46 (83. 6%) cases were effec-tively treated; In the second group for auricular acupuncture, 34 (91. 6% ) cases (68 eyes) out of 37cases (74 eyes) were improved; There were 50 cases (100 eyes) in the third group for boyauricular-acupuncture, among which 48 (96. 0%) cases (96 eyes) were improved. The curative effects of thethird group were better than those of the other two groups.

关键词： Epidemic hemorrhagic conjunctivitis Body acupuncture therapy Auricular acupuncture therapy

Comparative efficacy of marine Streptomyces formulation versus ciprofloxacin ophthalmic solution for treating Staphylococcus aureus-induced conjunctivitis in animal model

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Journal of Coastal Life Medicine 2016年第3期4卷 203-206页

作者： Femina Wahaab Kalidass Subramaniam Morris Jawahar Department of Biotechnology School of Biotechnology and Health SciencesKarunya UniversityCoimbatoreTamil NaduIndia

Objective:To report the efficacy of marine actinomycetes in controlling Staphylococcus aureus(***)-induced conjunctivitis in experimental ***:The ethyl acetate extracts of the best isolates of actinomycetes from the soil samples of Rameswaram coastal regions,Tamil Nadu,India,were concentrated and re-constituted in buffer and used as actinomycetes ophthalmic suspension in this *** anti-inflammatory efficacy of actinomycetes ophthalmic suspension was analysed in controlling *** conjunctivitis in rabbit in comparison with that of ***:Among the four best isolates,the RAM25C4 isolate had the highest antimicrobial activity in the secondary *** life studies indicated that the activity can be retained for 75 days when it was stored at 8℃and the optimum temperature for storage was between–20℃and 30℃.The animal model studies indicated that there was a profound anti-conjunctivitis *** actinomycetes ophthalmic suspension had better activity than ciprofloxacin ophthalmic ***:This is the first time to report that Streptomyces bacillaris strain RAM25C4 has antimicrobial effect in controlling ophthalmic pathogen *** under in vitro condition and the in vivo anti-inflammatory activity in controlling ***-induced conjunctivitis.

关键词： conjunctivitis Staphylococcus aureus Streptomyces Antibacterial activity Ciprofloxacin

Pediatric allergic conjunctivitis and allergic rhinitis

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Journal of Nanjing Medical University 2008年第3期22卷 183-187页

作者： Tong Qiao Yizhen Hu Zhinan Wang Department of Ophthamology the Union Hospital Affiliated to Huazhong University of Science and Technology Wuhan 430022 Hubei Province China Department of E.N.T Wuhan Children＇ s Hospital Wuhan 430016Hubei Province China

Objective： To assess the relationship between allergic conjunctivitis（AC） and allergic rhinitis（AR） in pediatric ophthalmology and E.N.T outpatient clinic. Methods：Eight hundred and ninety two patients were enrolled in survey during Mar. 2005-Jan. 2007, 407 allergic conjunctivitis cases were placed in the ophthalmology clinic group and 485 allergic rhinitis cases were from the E.N.T clinic. The comorbid disorders, histories, symptoms, signs of patients were recorded. Type 1 allergy was tested in 479 cases by a specific IgE antibody blood test. Eosinophils were detected in superficial conjunctival scrapings of the superior tarsal conjunctiva and mucosa surface scrapings of middle nasal meatus in 88 cases with both diseases. Results：302（74%）, 374（92%）, 116（29%） in 407 cases with allergic conjunctivitis had concomitant eczema, rhinitis and asthma, respectively; 334（69%）, 430（89%）, 145（30%） in 485 cases with allergic rhinitis had concomitant eczema, allergic conjunctivitis and asthma, respectively. The prevalence of allergic conjunctivitis concomitant allergic rhinitis and allergic rhinitis concomitant allergic conjunctivitis had no significant difference（x2=2,6, P 〉 0.05）. The prevalence of allergic conjunctivitis and allergic rhinitis concomitant eczema and asthma also had no significant difference （x2=3.08; x2=0.21, P 〉 0.05）. The degree of severity of two kinds of disease symptoms is not parallel, in the patients with seasonal allergic conjuctivitis（SAC） and perennial allergic conjunctivitis（PAC）, the clinical signs of AR were always severer（x2=258.2, P 〈 0.05） than those of AC. However, the results coincided with the cases with vernal keratoconjuctivitis（VKC）（x2=66.5, P 〈 0.05）; Eosinophils were revealed in 50（57%） conjunctival scrapings and nasal mucosa scrapings（x2=1.5, P〉 0.05）, 47（53%） cases had positive results in both scrapings. The main aeroallergens were house dust mites, house dust and fungi, and the main food-allergens were fish, crab and shrimp. Conclusi

关键词： allergy conjunctivitis rhinitis

Neuronal FceRI mediates acute and chronic conjunctivitis itch

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解剖学杂志 2021年第S1期44卷 79-79页

作者： Cui Huan Liu Fan Wang Tao Yuan Bo Ma Chao Department of Human Anatomy Histology and EmbryologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesBeijing 100005China

Although ocular itch in allergic conjunctivitis(ACJ)is conventionally thought to result from proinflammation mediators,especially released by mast cells,the unsatisfying effect of anti-histamine strategy indicates that ocular itch and conjunctival inflammation are at least partially *** we showed that FceRI,an immune receptor for IgE immune complex(IgE-IC),was expressed in a subpopulation of conjunctivitis sensory neurons and IgG-IC directly activated these neurons to evoke acute ocular itch without obvious concurrent inflammation and mast cells activation for naive *** effects were diminished in both global and MrgprA3+neuron-specific Fcer1-knockout mice,but not in mast cell deficient mice.

关键词： inflammation conjunctivitis acute

Effect of diluted povidone iodine in adenoviral keratoconjunctivitis on the rate of subepithelial corneal infiltrates

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1420-1425页

作者： Rana Altan-Yaycioglu Nedime Sahinoglu-Keskek Handan Canan Muge Coban-Karatas Burak Ulas Department of Ophthalmology Baskent University School of Medicine

AIM: To evaluate the clinical characteristics of adenoviral keratoconjunctivitis, the management modalities, as well as the incidence of subepithelial corneal infiltrates(SEI).METHODS: Patients with characteristic clinical symptoms and signs, who presented to our clinic within the first week of symptoms and received the diagnosis of adenoviral keratoconjunctivitis between January 2013 and April 2016, were included in the study. A total of 211 patients were included in the study. Patients were evaluated for the incidence of clinical signs, late complications, management preferences, and the effect of diluted povidone-iodine(d-PVP-I) 2%. RESULTS: Patients’ mean age was 33.03±14.76 y. We observed an increase in the number of cases according to the years. At presentation and/or early follow-up, the clinical signs were conjunctival hyperemia(100%), conjunctival follicules(79.1%), edema of the eyelids(39.3%), chemosis(16.1%), pseudomembrane formation(16.6%), and corneal epitheliopathy(29.9%). During late follow-up 13.3% patients developed conjunctival subepithelial fibrosis, and 39.8% developed SEI. A significant decrease in the incidence of SEI development was observed in patients who used d-PVP-I 2%(P=0.032;33.3% vs 45.9%, respectively in patients who received d-PVP-I 2% and who did not).CONCLUSION: Adenoviral keratoconjunctivitis has a tremendous effect on patient’s comfort and abilities in short-term. Additionally, almost half of the patients develop visual problems related to SEI. According to our clinical experience, using d-PVP-I 2% in the first days of adenoviral keratoconjunctivitis might be helpful in reducing the risk of SEI as a complication.

关键词： conjunctivitis corneal opacity infectious keratoconjunctivitis keratoconjunctivitis povidone-iodine viral conjunctivitis