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compound sophorae decoction:treating ulcerative colitis by affecting multiple metabolic pathways

Chinese Journal of Natural Medicines 2021年第4期19卷 267-283页

作者： HONG Zong-Chao CAI Quan WU He-Zhen YANG Yan-Fang FAN Heng DUAN Xue-Yun Hubei University of Chinese Medicine Wuhan 430065China Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430061China Hubei Province Academy of Traditional Chinese Medicine Wuhan 430074China Department of Integrated Traditional Chinese and Western Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Huangshi No.5 Hospital Huangshi 435005China

Ulcerative colitis(UC)is a chronic refractory non-specific intestinal inflammatory disease that is difficult to be *** discovery of new ulcerative colitis-related metabolite biomarkers may help further understand UC and facilitate early *** may also provide a basis for explaining the mechanism of drug action in the treatment of *** sophorae decoction(CSD)is an empirical formula used in the clinical treatment of *** it is known to be efficacious,its mechanism of action in the treatment of UC is *** purpose of this study was to investigate the changes in endogenous substances in UC rats and the effects of CSD on metabolic pathways using the metabonomics *** studies in rats with UC and normal rats were performed using LC-MS/*** with UC induced using TNBS enema were used as the study *** profiling and pathway analysis of biomarkers was performed using statistical and pathway enrichment analyses.36 screened potential biomarkers were found to be significantly different between the UC and the normal groups;it was also found that CSD could modulate the levels of these potential *** was found to be efficacious in UC by regulating multiple metabolic pathways.

关键词： compound sophorae decoction Ulcerative colitis LC-MS/MS Biomarker Metabolomics

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Effect of compound sophorae decoction in the treatment of ulcerative colitis by tissue extract metabolomics approach

引用

Journal of Traditional Chinese Medicine 2021年第3期41卷 414-423页

作者： HONG Zongchao CAI Quan DUAN Xueyun YANG Yanfang WU Hezhen JIANG Nan FAN Heng College of Pharmacy Hubei University of Chinese MedicineWuhan 430065China Department of Integrated Traditional Chinese and Western Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan430061China Hubei Province Academy of Traditional Chinese Medicine Wuhan430074China

OBJECTIVE: To investigate how compound sophorae decoction(CSD) works on rats' models of ulcerative colitis(UC) induced by 2,4,6-trinitrobenzenesulfonic acid solution(TNBS) by metabolomics studies of colon, liver, and kidney tissue ***: Rats with UC induced by TNBS enema were used as models in this study. Metabolic profiles of the three tissues were analyzed and pathway analysis of biomarkers was performed after CSD administration and further integration of metabolic ***: Thirteen biomarkers were screened from colon, liver, and kidney tissue extracts, and the levels of these substances were up-or down-regulated in the model group, but their levels were reversed after CSD administration. These biomarkers were mainly related to Phenylalanine, tyrosine and tryptophan biosynthesis, Phenylalanine metabolism, Glutathione metabolism, Arachidonic acid metabolism, Nicotinate and nicotinamide metabolism,Alanine, aspartate and glutamate ***: CSD could significantly ameliorate the symptoms of UC by regulating multiple metabolic pathways.

关键词： colitis ulcerative metabolomics trinitrobenzenesulfonic acid compound sophorae decoction

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