Effect of compound Sophorae decoction in the treatment of ulcerative colitis by tissue extract metabolomics approach

作     者：HONG Zongchao CAI Quan DUAN Xueyun YANG Yanfang WU Hezhen JIANG Nan FAN Heng HONG Zongchao;CAI Quan;DUAN Xueyun;YANG Yanfang;WU Hezhen;JIANG Nan;FAN Heng

作者机构：College of PharmacyHubei University of Chinese MedicineWuhan 430065China Department of Integrated Traditional Chinese and Western MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Provincial Hospital of Traditional Chinese MedicineWuhan430061China Hubei Province Academy of Traditional Chinese MedicineWuhan430074China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2021年第41卷第3期

页      面：414-423页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the Chinese National Natural Science Foundation (Immunomodulatory Mechanism of Bmsc Evs Mediated by Ephb2/Ephrin-b1 Pathway in Ulcerative Colitis and Synergistic Effect of Compound Sophorae decoction  No.81774093) 

主　　题：colitis ulcerative metabolomics trinitrobenzenesulfonic acid compound Sophorae decoction 

摘      要：OBJECTIVE: To investigate how compound Sophorae decoction(CSD) works on rats models of ulcerative colitis(UC) induced by 2,4,6-trinitrobenzenesulfonic acid solution(TNBS) by metabolomics studies of colon, liver, and kidney tissue ***: Rats with UC induced by TNBS enema were used as models in this study. Metabolic profiles of the three tissues were analyzed and pathway analysis of biomarkers was performed after CSD administration and further integration of metabolic ***: Thirteen biomarkers were screened from colon, liver, and kidney tissue extracts, and the levels of these substances were up-or down-regulated in the model group, but their levels were reversed after CSD administration. These biomarkers were mainly related to Phenylalanine, tyrosine and tryptophan biosynthesis, Phenylalanine metabolism, Glutathione metabolism, Arachidonic acid metabolism, Nicotinate and nicotinamide metabolism,Alanine, aspartate and glutamate ***: CSD could significantly ameliorate the symptoms of UC by regulating multiple metabolic pathways.