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Effectiveness of Huai Qi Huang Granules on Juvenile collagen-induced Arthritis and Its Influence on Pyroptosis Pathway in Synovial Tissue

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Current Medical Science 2019年第5期39卷 784-793页

作者： Ting HE Xie XU Xin-yan ZHANG Pan SHEN Jia-yun LING Yan-xin-li HAN Yu WEN Xiu-fen HU Hui-ling LU Division of Pediatric Rheumatology and Immunology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Summary:Huai Qi Huang(HQH)exerts great effects in clinic,such as anti-inflammation,immune-regulation,anti-cancer,and so ***,the mechanism by which HQH protects juvenile idiopathic arthritis(JIA)is ***,we explored deeply the protective mechanisms in juvenile collagen-induced arthritis(CIA)rat *** is Gasdermin D(GSDMD)-dependent programmed cell death,involved in many diseases,such as *** investigated whether GSDMD-induced pyroptosis take part in mechanisms of juvenile CIA *** Wistar rats(3-4 weeks)were injected intradermally with fully emulsified bovine typeⅡcollagen and complete Freund's adjuvant to establish CIA rat ***,the CIA rats received oral administration of HQH(4.16 g/kg)once a day from the day 21 of modeling,with the treatment lasting for 28 *** of indicators were measured for evaluation of anti-inflammation effect of HQH,including hind paw swelling,arthritis scores,micro CT,and histopathological changes and the level of pro-inflammatory cytokines in the serum,including tumor necrosis factor alpha(TNF-α)and interleukin-18(IL-18).The expression of GSDMD and caspasein the joint synovial tissues was *** results demonstrated that the expression of the pyroptotic protein GSDMD and its upstream caspase-1 was significantly increased in the synovial tissues of CIA *** treatment of HQH ameliorated the symptoms in CIA rats,reduced levels of pro-inflammatory cytokines and hind paw swelling,down-regulated the expression of GDSMD and *** pyroptosis participated in the pathogenesis of CIA *** study supported that HQH can effectively improve joints inflammation of juvenile collagen-induced arthritis rats by inhibiting pyroptosis pathway in the joint synovial tissues.

关键词： Huai Qi Huang juvenile collagen-induced arthritis Gasdermin D pyroptosis

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Contributions of neutrophils to the adaptive immune response in autoimmune disease

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World Journal of Translational Medicine 2015年第3期4卷 60-68页

作者： Kathryn M Pietrosimone Peng Liu Thurston Arthritis Research Center University of North Carolina at Chapel Hill Department of Medicine and Thurston Arthritis Research Center University of North Carolina at Chapel Hill

Neutrophils are granulocytic cytotoxic leukocytes of the innate immune system that activate during acute inflammation. Neutrophils can also persist beyond the acute phase of inflammation to impact the adaptive immune response during chronic inflammation. In the context of the autoimmune disease, neutrophils modulating T and B cell functions by producing cytokines and chemokines, forming neutrophil extracellular traps, and acting as or priming antigen presentation cells. Thus, neutrophils are actively involved in chronic inflammation and tissue damage in autoimmune disease. Using rheumatoid arthritis as an example, this review focuses on functions of neutrophils in adaptive immunity and the therapeutic potential of these cells in the treatment of autoimmune disease and chronic inflammation.

关键词： Neutrophils Chronic inflammation Autoimmune disease Rheumatoid arthritis collagen-induced arthritis

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