Contributions of neutrophils to the adaptive immune response in autoimmune disease

作     者：Kathryn M Pietrosimone Peng Liu 

作者机构：Thurston Arthritis Research Center University of North Carolina at Chapel Hill Department of Medicine and Thurston Arthritis Research Center University of North Carolina at Chapel Hill 

出 版 物：《World Journal of Translational Medicine》 (世界转化医学杂志)

年 卷 期：2015年第4卷第3期

页      面：60-68页

学科分类：10[医学] 

基　　金：Supported by The National Institute of Arthritis and Muscu-loskeletal and Skin Diseases of the National Institutes of Health(NIAMS-NIH) No.1R01AR063132 

主　　题：Neutrophils Chronic inflammation Autoimmune disease Rheumatoid arthritis Collagen-induced arthritis 

摘      要：Neutrophils are granulocytic cytotoxic leukocytes of the innate immune system that activate during acute inflammation. Neutrophils can also persist beyond the acute phase of inflammation to impact the adaptive immune response during chronic inflammation. In the context of the autoimmune disease, neutrophils modulating T and B cell functions by producing cytokines and chemokines, forming neutrophil extracellular traps, and acting as or priming antigen presentation cells. Thus, neutrophils are actively involved in chronic inflammation and tissue damage in autoimmune disease. Using rheumatoid arthritis as an example, this review focuses on functions of neutrophils in adaptive immunity and the therapeutic potential of these cells in the treatment of autoimmune disease and chronic inflammation.