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In vivo inducing collagen regeneration of biodegradable polymer microspheres

Regenerative Biomaterials 2021年第5期8卷 95-107页

作者： Yixin Zhang Hanwen Liang Qian Luo Jianlin Chen Nan Zhao Wenxia Gao Yuji Pu Bin He Jing Xie School of Smart Health Chongqing College of Electronic EngineeringChongqing 401331China School of Laboratory Medicine Sichuan Provincial Engineering Laboratory for Prevention and Control Technology of Veterinary Drug Residue in Animal-origin FoodChengdu Medical CollegeChengdu 610500China Puliyan(Nanjing)Medical Science&Technology Co.LTD Nanjing 211500China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325027China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Stomatology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China

Biodegradable polymer particles have been used as dermal fillers for pre-clinical and clinical *** impact of material properties of polymers is very important to develop products for aesthetic medicine such as dermal ***,eight biodegradable polymers with different molecular weights,chemical compositions or hydrophilic-hydrophobic properties were prepared and characterized for systematical study for aesthetic medicine *** microspheres with 20-100 lmwere *** in vitro degradation study showed that poly(L-lactic-co-glycolic acid)75/25 microspheres degraded the fastest,whereas poly(L-lactic acid)(PLLA)microspheres with intrinsic viscosity of 6.89([g]¼6.89)with the highest molecular weight showed the slowest degradation *** these microspheres were fabricated dermal fillers according to the formula of SculptraVR,they were injected subcutaneously into the back skin of *** vivo results demonstrated that the degradation rate of microspheres strongly correlated with the foreign body reaction and collagen regeneration was induced by *** microspheres with faster degradation rate induced inflammatory response and the collagen regeneration maintained in shorter ***([g]¼3.80)microsphere with a moderate molecular weight and degradation rate could strongly regenerate Type I and III collagen to maintain a long-term aesthetic medicine *** properties of size,morphology and degradation behavior would influence the foreign body reaction and collagen regeneration.

关键词： biodegradable polymers microspheres collagen regeneration dermal fillers

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Superiority of poly(L-lactic acid)microspheres as dermal fillers

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Chinese Chemical Letters 2021年第1期32卷 577-582页

作者： Quan Gao Lijie Duan Xiangru Feng Weiguo Xu School of Chemistry and Life Science Changchun University of TechnologyChangchun 130012China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

The demand for injectable dermal filler has unde rgone significant growth with the rapid development of the beauty ***(lactic acid)(PLA) as a benefit of excellent biocompatibility and long-term promotion of collagen regeneration has been favored as a commonly used ***,the effects of chirality and particle size of PLA on the efficacy of dermal filler have not been *** this study,we prepared three kinds of microspheres(MSs) consisting of poly(D-lactic acid)(PDLA MS),poly(L-lactic acid)(PLLA MS),or meso-PLA(PDLLA MS)at 5,10 and 20 μmto reveal the different biological functions as dermal *** intradermal injection into guinea pig,it was found that PLLA MS induced the slightest inflammation,and the level of pro-inflammatory cytokine IL-1β induced by PLLA MS is only 0.3 or 0.7-fold of that induced by PDLA or PDLLA MS,*** importantly,PLLA MS significantly stimulated the regeneration of collagen,which was 1.4 or 1.1 times higher than those stimulated by PDLA MS or PDLLA MS,*** size of PLA MSs did not affect the levels of inflammation and collagen *** results confirmed the superiority of PLLA as a dermal filler.

关键词： Chiral poly(L-lactic acid) Particle collagen regeneration Inflammation inhibition Dermal filler

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