In vivo inducing collagen regeneration of biodegradable polymer microspheres

作     者：Yixin Zhang Hanwen Liang Qian Luo Jianlin Chen Nan Zhao Wenxia Gao Yuji Pu Bin He Jing Xie 

作者机构：School of Smart HealthChongqing College of Electronic EngineeringChongqing 401331China School of Laboratory MedicineSichuan Provincial Engineering Laboratory for Prevention and Control Technology of Veterinary Drug Residue in Animal-origin FoodChengdu Medical CollegeChengdu 610500China Puliyan(Nanjing)Medical Science&Technology Co.LTDNanjing 211500China College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325027China National Engineering Research Center for BiomaterialsSichuan UniversityChengdu 610064China Department of StomatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2021年第8卷第5期

页      面：95-107页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by the National Science Foundation of China(51773130) Sichuan Science and Technology Program(2019JDRC0098) SCU-Enterprise Joint Project(18H0350) Sichuan Province Health Department(18P J553) 

主　　题：biodegradable polymers microspheres collagen regeneration dermal fillers 

摘      要：Biodegradable polymer particles have been used as dermal fillers for pre-clinical and clinical *** impact of material properties of polymers is very important to develop products for aesthetic medicine such as dermal ***,eight biodegradable polymers with different molecular weights,chemical compositions or hydrophilic-hydrophobic properties were prepared and characterized for systematical study for aesthetic medicine *** microspheres with 20-100 lmwere *** in vitro degradation study showed that poly(L-lactic-co-glycolic acid)75/25 microspheres degraded the fastest,whereas poly(L-lactic acid)(PLLA)microspheres with intrinsic viscosity of 6.89([g]¼6.89)with the highest molecular weight showed the slowest degradation *** these microspheres were fabricated dermal fillers according to the formula of SculptraVR,they were injected subcutaneously into the back skin of *** vivo results demonstrated that the degradation rate of microspheres strongly correlated with the foreign body reaction and collagen regeneration was induced by *** microspheres with faster degradation rate induced inflammatory response and the collagen regeneration maintained in shorter ***([g]¼3.80)microsphere with a moderate molecular weight and degradation rate could strongly regenerate Type I and III collagen to maintain a long-term aesthetic medicine *** properties of size,morphology and degradation behavior would influence the foreign body reaction and collagen regeneration.