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The improvement of dispersity, thermal stability and mechanical properties of collagen fibers by silane modification: an exploration for developing new leather making technology

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Journal of Leather Science and Engineering 2022年第3期4卷 358-368页

作者： Shuangfeng Xu Hanzhong Xiao Bi Shi Department of Biomass Chemistry and Engineering Sichuan UniversityChengdu 610065People’s Republic of China National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan UniversityChengdu 610065People’s Republic of China

The effect of hydrophobic modification on the performances of collagen fibers(CFs)was investigated by using silane coupling agents with different alkyl chains as hydrophobic modifiers.It was found silane could be easily grafted onto CF surface through covalent bonds under 5%water content.This modification led to the transformation of surface wettability of CF from hydrophilic to hydrophobic.Interestingly,the change of surface wettability resulted in substantial improvement of the modified CF properties,presenting well dispersity of collagen fibers,higher thermal stability and enhanced mechanical properties in comparison with natural CF.The degree of improvement mainly depended on the length of alkyl chain in silane.Longer alkyl chain produced strong hydrophobicity and subsequently more superior performances of the modified CF.When the length of alkyl chain increased to 18 carbon atoms,the modified CF possessed durable superhydrophobicity even exposed to aqueous solutions of different pH,UV,and organic solvents,and had excellent thermal and mechanical properties like leather fibers.In general,this work clearly revealed that the properties of CF are closely and positively related to the hydrophobicity,which is suggestive in developing new leather making technology.

关键词： Hydrophobic modification collagen fibers Silane New leather-making technology

Anti-abrasion collagen fiber-based membrane functionalized by UiO-66-NH_(2)with ultra-high efficiency and stability for oil-in-water emulsions separation

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Chinese Journal of Chemical Engineering 2024年第2期66卷 285-297页

作者： Xiaoxia Ye Rixin Huang Zhihong Zheng Juan Liu Jie Chen Yuancai Lv College of Environmental and Safety Engineering Fuzhou UniversityFuzhou 350108China College of Chemical Engineering Fuzhou UniversityFuzhou 350108China

Membrane separation strategies offer promising platform for the emulsion separation.However,the low mechanical strength of membrane separation layers and the trade-off between separation flux and efficiency present significant challenges.In this study,we report a CFM@UiO-66-NH_(2)membrane with high separation flux,efficiency and stability,through utilizing a robust anti-abrasion collagen fiber membrane(CFM)as the multifunctional support and UiO-66-NH_(2)by an in-situ growth as the separation layer.The high mechanical strength of the CFM compensated for the weakness of the separation layer,while the charge-breaking effect of UiO-66-NH_(2),along with the size sieving of its constituent separating layers and the capillary effect of the collagen fibers,contributed to the potential for efficient separation.Additionally,the CFM@UiO-66-NH_(2)membrane exhibited superhydrophilic properties,making it suitable for separating oil-in-water microemulsions and nanoemulsions stabilized by anionic surfactants.The membrane demonstrated remarkable separation efficiencies of up to 99.960%and a separation flux of370.05 L·m^(-2)·h^(-1).Moreover,it exhibits stability,durability,and abrasion resistance,maintaining excellent separation performance even when exposed to strong acids and alkalis without any damage to its structure and performance.After six cycles of reuse,it achieved a separation flux of 417.97 L·m^(-2)·h^(-1)and a separation efficiency of 99.747%.Furthermore,after undergoing 500 cycles of strong abrasion,the separation flux remained at 124.39 L·m^(-2)·h^(-1),with a separation efficiency of 99.992%.These properties make it suitable for the long-term use in harsh operating environments.We attribute these properties to the electrostatic effect resulting from the amino group on UiO-66-NH_(2)and its in-situ growth on the CFM,which forms a size-screening separation layer.Our work highlights the potential of the CFM@UiO-66-NH_(2)membrane as an environmentally friendly size-screening material for the efficient emulsion wastewater

关键词： collagen fibers Metal-organic frameworks Oil-in-water emulsion separation Size sieving

Adsorption Kinetics of Water onto collagen fibers

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Adsorption Kinetics of Water onto Collagen Fibers

Electrical stimulation does not enhance nerve regeneration if delayed after sciatic nerve injury: the role of fibrosis

2007年全国高分子学术论文报告会

作者： Keyong TANG Lianmei TU School of Materials Science and Engineering,Zhengzhou University,450052

＜正＞The adsorption kinetics of water onto untanned and tanned collagen fibersunder batch equilibrium experimental ntal conditions at 20+2℃ was investigated.Experimental results have shown that water uptake was rapi... 详细信息

关键词： collagen fibers water adsorption kinetics

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Neural Regeneration Research 2015年第1期10卷 90-94页

作者： Na Han Chun-gui Xu Tian-bing Wang Yu-hui Kou Xiao-feng Yin Pei-xun Zhang Feng Xue Department of Trauma and Orthopedics Peking University People’s Hospital

Electrical stimulation has been shown to accelerate and enhance nerve regeneration in sensory and motor neurons after injury, but there is little evidence that focuses on the varying degrees of fibrosis in the delayed repair of peripheral nerve tissue. In this study, a rat model of sciatic nerve transec- tion injury was repaired with a biodegradable conduit at 1 day, 1 week, 1 month and 2 months after injury, when the rats were divided into two subgroups. In the experimental group, rats were treated with electrical stimuli of frequency of 20 Hz, pulse width 100 ms and direct current voltage of 3 V; while rats in the control group received no electrical stimulation after the conduit operation. His- tological results showed that stained collagen fibers comprised less than 20% of the total operated area in the two groups after delayed repair at both 1 day and 1 week but after longer delays, the collagen fiber area increased with the time after injury. Immunohistochemical staining revealed that the expression level of transforming growth factor ~ （an indicator of tissue fibrosis） decreased at both 1 day and 1 week after delayed repair but increased at both 1 and 2 months after delayed repair. These findings indicate that if the biodegradable conduit repair combined with electrical stimulation is delayed, it results in a poor outcome following sciatic nerve injury. One month after injury, tissue degeneration and distal fibrosis are apparent and are probably the main reason why electrical stimulation fails to promote nerve regeneration after delayed repair.

关键词： nerve regeneration peripheral nerve injury electrical stimulation bioabsorbableconduit delayed repair fibroblast collagen fibers transforming growth factor ~ Masson staining neuroprotection immunohistochemistry NSFC grants neural regeneration

Scanning electron microscopic observation:three-dimensional architecture of the collagen in hepatic fibrosis rats

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Chinese Medical Journal 2007年第4期120卷 308-312页

作者： WANG Xiao-hong ZHAO Jing ZHANG Wei-guang ZHANG Li-ying, MA Rui-qiong WANG Li-qin ZHANG Shu-yong TIAN Long Department of Anatomy and Histoembryology Peking UniversityHealth Science Center Beijing 100083 China

Background In the process of hepatic fibrosis, the accumulation of collagen fibers is strongly related to the hepatic function. The aim of this study was to investigate the three-dimensional architecture of the collagen network in the liver of rats with hepatic fibrosis. Methods Healthy adult male Wistar rats （n=32） were randomly divided into a control group （n=16） and a hepatic fibrosis group （n=16）. In the control group, the rats were treated with peanut oil while the rats in hepatic fibrosis group were treated for 10 weeks with 60% CCI4 diluted in peanut oil. The quantity of collagen fibers was detected by Western blotting; distribution of the collagen was detected by sirius red staining and polarized microscope; the three-dimensional architecture of collagen in the liver was observed under the scanning electron microscope after fixed tissues were treated with cell-maceration using NaOH. Statistical analysis was performed using the u test. Results The quantity of collagen fibers increased significantly in the hepatic fibrosis group. With the aggravation of hepatic fibrosis, collagen fibers gradually accumulated. They interlaced the reticulation compartment and formed a round or ellipse liver tissue conglomeration like a grape framework that was disparate and wrapped up the normal liver Iobule. The deposition of collagen fibers was obvious in adjacent hepatic parenchyma, especially around the portal tracts. Conclusion Our experiment showed the collagen proliferation and displays clearly the three-dimensional architecture of collagen fibers in rat liver with hepatic fibrosis by scanning electron microscope. It can provide a morphological foundation for the mechanisms of changed haemodynamics and portal hypertension in hepatic fibrosis.

关键词： hepatic fibrosis collagen fibers scanning electron microscope three-dimensional construct

Rapid and efficient characterization of cervical collagen orientation using linearly polarized colposcopic images

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Journal of Innovative Optical Health Sciences 2023年第5期16卷 21-31页

作者： Cat Phan Ngoc Khuong Dung Nguyen Huu Quang Hai Pham Thanh Long Nguyen Quynh Nguyen Ngoc Duc Le Huynh Tien Tran Van Tu Ly Anh Department of Applied Physics Ho Chi Minh City University of Technology 268 Ly Thuong Kiet Street District 10 Ho Chi Minh City 700000Vietnam Quality Management Department Tu Du Hospital 284 Cong QuynhDistrict 1 Ho Chi Minh City 700000Vietnam Department of Biomedical Engineering Nguyen Tat Thanh University 300A Nguyen Tat Thanh District 4Ho Chi Minh City 700000Vietnam Faculty of Science and Technology Jean Monnet University 11 Rue du Docteur Annino Saint Etienne 42000France

collagen provides tissue strength and structural integrity.Quanti fication of the orientated dispersion of collagen fibers is an important factor when studying the mechanical properties of the cervix.In this study,for the first time,a new method for rapid characterization of the collagen fiber orientations of the cervix using linearly polarized light colposcopy is presented.A total of 24 colposcopic images were captured using a cross-polarized imaging system with white LED light sources.In the preprocessing stage,the Red channel of the RGB image was chosen,which contains no information of the blood vessels because of the low-absorption of blood cells in the red region.OrientationJ,which is an ImageJ plug-in,was used to estimate the local orientation of the collagen fibers.The result shows that in the nonpregnant cervix,the middle zone(Zone 2)has circumferentially aligned collagen fibers while the inner zone(Zone 1)has randomly arranged.The collagen fiber dispersion in Zone 2 is much smaller than that in Zone 1 at all four quadrants region(anterior,posterior,left,and right quadrant).This new analysis technique could potentially combine with diagnostic tools to provide a quantitative platform of collagen fibers in the clinic.

关键词： Cervix collagen fibers collagen orientation coherency cross-polarized imaging colposcopy

Topical application of silk fibroin-based hydrogel in preventing hypertrophic scars

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Topical application of silk fibroin-based hydrogel in preven...

Effects of aging on the architecture of the ileocecal junction in rats

中国蚕学会2021年学术年会

作者： Zheng Li Jiangbo Song Jianfei Zhang Kaige Hao Lian Liu Baiqing Wu Xinyue Zheng Bo Xiao Xiaoling Tong Fangyin Dai State Key Laboratory of Silkworm Genome Biology Key Laboratory for Sericulture Biology and Genetic BreedingMinistry of Agriculture and Rural AffairsCollege of BiotechnologySouthwest University

Current medications for the treatment of hypertrophic scars suffer from bottlenecks of limited therapeutic efficacy and a slow recovery rate.Silk fibroin（SF） has gained attention for its ability to promote wound healing in burns and cutaneous wounds,but its therapeutic effects against hypertrophic scar have not been thoroughly investigated.We prepared SF-based hydrogels（SFHs） with various SF concentrations（1.5 %,3 %,and 6 %） and characterized their physicochemical properties.Cell experiments showed that these SFHs had favorable biocompatibility in vitro.Further animal experiments in rabbits revealed that the SFH（3 %）-treated group achieved scars on their ears that were thinner and significantly lighter in color compared with the negative control group.Moreover,treatment with SFHs reduced the density and led to the orderly arrangement of collagen fibers.It was found that the therapeutic effects of SFHs were attributed to the reduced expression levels of α-smooth muscle actin.These results are the first to demonstrate that SFH can be exploited as an effective therapeutic agent for the treatment of hypertrophic scars.

关键词： Silk fibroin-based hydrogel hypertrophic scar collagen fibers α-Smooth muscle actin

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第3期7卷 416-427页

作者： Maria Cícera de Brito Renato Paulo Chopard Diego Pulzatto Cury Ii Sei Watanabe Cristina Eusébio Mendes Patricia Castelucci Department of Surgery Faculty of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo Department of Anatomy/Biomedical Science Institute University of Sao Paulo

AIM: To evaluate the structural organization of the elastic and collagen fibers in the region of the ileocecal transition in 30 young and old male Wistar rats. METHODS: Histology, immunohistochemistry(IHC), transmission electron microscopy and scanning electron microscopy were employed in this study. The results demonstrated that there was a demarcation of the ileocecal region between the ileum and the cecum in both groups. RESULTS: The connective tissue fibers had different distribution patterns in the two groups. IHC revealed the presence of nitric oxide synthase, enteric neurons and smooth muscle fibers in the ileocecal junctions(ICJs) of both groups. Compared to the young group, the elderly group exhibited an increase in collagen type Ⅰ?fibers, a decrease in collagen type Ⅲ fibers, a decreased linear density of oxytalan elastic fibers, and a greater linear density of elaunin and mature elastic fibers. CONCLUSION: The results revealed changes in the patterns of distribution of collagen and elastic fibers that may lead to a possible decrease in ICJ functionality.

关键词： Ileocecal junction Elastic fibers collagen fibers Aging Rats

The role of TGF-β1/Smad/CTGF pathway in The Fibrous-Muscular Alterations of Corpus Cavernosum Related to Streptozotocin-Induced Diabetic

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The role of TGF-β1/Smad/CTGF pathway in The Fibrous-Muscula...