检索结果-南通市图书馆

A novel aged mouse model of recurrent intracerebral hemorrhage in the bilateral striatum

Neural Regeneration Research 2023年第2期18卷 344-349页

作者： Li-Min Wang Zhi-Hua Liu Hong-Lei Ren Xue-Mei Chen Jun-Min Wang Hui-Min Cai Li-Ping Wei Hui-Hong Tian Jian Wang Li-Juan Wang The Second School of Clinical Medicine Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangdong Neuroscience InstituteGuangzhouGuangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhouGuangdong ProvinceChina Department of Neurology Tianjin Neurological InstituteTianjin Medical University General HospitalTianjinChina Department of Anatomy School of Basic Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina

The current animal models of stroke primarily model a single intracerebral hemorrhage(ICH)attack,and there is a lack of a reliable model of recurrent *** this study,we established 16-month-old C57 B L/6 male mouse models of ICH by injecting collagenaseⅦ-S into the left ***-one days later,we injected collagenaseⅦ-S into the right striatum to simulate recurrent *** results showed that mice subjected to bilateral striatal hemorrhage had poorer neurological function at the early stage of hemorrhage,delayed recovery in locomotor function,motor coordination,and movement speed,and more obvious emotional and cognitive dysfunction than mice subjected to unilate ral striatal *** findings indicate that mouse models of bilateral striatal hemorrhage can well simulate clinically common recurrent *** models should be used as a novel tool for investigating the pathogenesis and treatment targets of recurrent ICH.

关键词： animal model cognition impairment depression-like behavior dopaminergic neurons emotion intracerebral hemorrhage motor neurologic function recurrent intracerebral hemorrhage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Music therapy is a potential intervention for cognition of Alzheimer’s Disease:a mini-review

引用

Translational Neurodegeneration 2017年第1期6卷 6-13页

作者： Rong Fang Shengxuan Ye Jiangtao Huangfu David P.Calimag Department of Medicine Section of NeurologySaint Anthony Hospital2875 West 19th StreetChicagoIL 60623USA Intent Inc. NingboZhejiang 315000China Laboratory of Applied Research on Electromagnetics(ARE) Zhejiang UniversityHangzhou 310027China

Alzheimer’s Disease(AD)is a global health issue given the increasing prevalence rate and the limitations of drug *** a consequent,non-pharmacological interventions are of *** therapy(MT)is a nonpharmacological way with a long history of use and a fine usability for dementia *** this review,we will summarize different techniques,diverse clinical trials,and the mechanisms of MT as it is helpful to the cognition in AD,providing reference for future *** articles have demonstrated that MT can reduce cognitive decline especially in autobiographical and episodic memories,psychomotor speed,executive function domains,and global *** is a promising intervention for strategy of dementia especially of AD and it must be started as early as ***,more evidences with prospective,randomized,blinded,uniform and rigorous methodological investigations are *** we should consider to combine MT with other cognitive stimulations such as dance,physical exercise,video game,art and so on.

关键词： Alzheimer’s disease(AD) Music therapy(MT) cognition impairment Non-pharmacological intervention Clinical trial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Duration of hypertension is associated with cognitive function： a cross-sectional study in Chinese adults

引用

Chinese Medical Journal 2014年第11期127卷 2105-2110页

作者： Li Tuo Bai Yu Xiang Junwu Wang Rui Bai Jie Tuo Xiping Zhao Zhongxin Department of Endocrinology Changzheng Hospital Shanghai 200001 China Department of Gastroenterology Changhai Hospital Shanghai 200433 China Department of General Surgery 208 Hospital Shengyang Liaoning 130000 China Department of Health Statistics Second Military Medical University Shanhgai 200433 China Department of Geriatrics Changhai Hospital Shanghai 200433 China Department of Neurology Changzheng Hospital Shanghai 200001 China

Background Hypertension （HTN） is a very prevalent public health problem and as the population ages,cognitive impairment （CI） is also going to be a public health ***,the relationship between hypertension duration and cognitive function declination worldwide is still *** aim of the study was to investigate the effects of HTN duration on CI in Chinese *** At baseline,1 386 HTN patients and 293 normotensive （NT） people were *** HTN patients were further divided into four subgroups （duration of HTN 〈6 years,6-10 years,11-20 years,and 〉20 years） according to the HTN duration and were screened for cognitive function with neuropsychological tests including mini-mental-state-examination （MMSE） and clock-drawing-test （CDT） in comparison with the NT *** More HTN patients had CI （45.3%） than NT subjects （30.4%）,and increased with HTN duration （P〈0.000 1）.Compared with the scores of MMSE and CDT in the NT group,the declines were higher in the HTN patients （P 〈0.000 1）,and in the four HTN subgroups,both MMSE and CDT scores fall when the HTN duration increased （P 〈0.05）.Furthermore,in the HTN population without CI,the trend in alteration of CI was relatively mild but still existed （P 〈0.05）.Conclusion People with HTN are more likely to have CI and the possibility and aggravation increases the prolongation of HTN duration,both in amnesic and nonamnesic function.

关键词： cognition impairment hypertension duration mini-mental-state-examination clock-drawing-test epidemiology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：