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Magnesium sulfate and fetal neuroprotection: overview of clinical evidence

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Neural Regeneration Research 2018年第12期13卷 2044-2049页

作者： Clément Chollat Stéphane Marret Institut National de la Santé et de la Recherche Médicale U1245 Genetics and Pathophysiology of Neurodevelopmental Disorders Team 4Neovasc Institute of Research and Innovation in Biomedicine Rouen School of Medicine Normandy University Department of Neonatal Intensive Care Port Royal University Hospital Department of Neonatal Pediatrics and Intensive Care and Neuropediatrics Charles-Nicolle University Hospital

Antenatal administration of magnesium sulfate is an important part of the neuroprotective strategy for preterm infants. Strong evidence from five randomized controlled trials and five meta-analyses has demonstrated that magnesium sulfate, when administered before preterm delivery, significantly reduces the risk of cerebral palsy at two years. Through secondary analyses of randomized controlled trials and other original clinical studies, this state-of-the-art review highlights the absence of serious adverse effects in both pregnant women and neonates, as well as the impact of maternal body mass index and preeclamptic status on the maternal and neonatal magnesium levels, which could influence the magnitude of the neuroprotective effect. Although antenatal magnesium sulfate is a cost-effective strategy, some practice surveys have demonstrated that the use of magnesium sulfate is not sufficient and that its use is heterogeneous, differing among different maternity wards. Since 2010, an increasing number of obstetrical societies have recommended its use to improve the neurological outcomes of preterm infants, especially the International Federation of Gynecology and Obstetrics and World Health Organization in 2015, and France in 2017. Considering the neuroprotective impact of magnesium sulfate when administered before delivery, postnatal administration should be considered, and its effects should be assessed using randomized controlled trials.

关键词： magnesium sulfate preterm birth neuroprotection cerebral palsy neurodevelopment international recommendations clinical studies meta-analysis preeclampsia cost-effectiveness

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Applications and safety of gold nanoparticles as therapeutic devices in clinical trials

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Journal of Pharmaceutical Analysis 2023年第9期13卷 960-967页

作者： Leeann Yao Dejan Bojic Mingyao Liu Latner Thoracic Surgical Research Laboratories Toronto General Hospital Research InstituteUniversity Health NetworkTorontoONM5G 1L7Canada Institute of Medical Science Temerty Faculty of MedicineUniversity of TorontoTorontoONM5S 1A8Canada Department of Surgery Medicine and PhysiologyTemerty Faculty of MedicineUniversity of TorontoTorontoONM5S 1A8Canada

Use of gold nanoparticles(GNPs)in medicine is an emerging field of translational research with vast clinical implications and exciting therapeutic ***,the safety of using GNPs in human subjects is an important question that remains *** study reviews over 20 clinical trials focused on GNP safety and aims to summarize all the clinical studies,completed and ongoing,to identify whether GNPs are safe to use in humans as a therapeutic *** these studies,GNPs were implemented as drug delivery devices,for photothermal therapy,and utilized for their intrinsic therapeutic effects by various routes of *** studies revealed no major safety concerns with the use of GNPs;however,the number of trials and total patient number remains ***-dose,multicenter blinded trials are required to deepen our understanding of the use of GNPs in clinical settings to facilitate translation of this novel,multifaceted therapeutic *** clinical trials will require collaboration between clinicians,scientists,and biotechnology companies.

关键词： Nanomedicine clinical studies Gold nanoparticles Safety Applications

Peritoneal adhesions after laparoscopic gastrointestinal surgery

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World Journal of Gastroenterology 2014年第17期20卷 4917-4925页

作者： Valerio Mais Division of Gynecology Obstetrics and Pathophysiology of Human ReproductionDepartment of Surgical SciencesUniversity of Cagliari09124 CagliariItaly

Although laparoscopy has the potential to reduce peritoneal trauma and post-operative peritoneal adhesion formation, only one randomized controlled trial and a few comparative retrospective clinical studies have addressed this issue. Laparoscopy reduces de novo adhesion formation but has no efficacy in reducing adhesion reformation after adhesiolysis. Moreover, several studies have suggested that the reduction of de novo post-operative adhesions does not seem to have a significant clinical impact. Experimental data in animal models have suggested that CO2 pneumoperitoneum can cause acute peritoneal inflammation during laparoscopy depending on the insufflation pressure and the surgery duration. Broad peritoneal cavity protection by the insufflation of a low-temperature humidified gas mixture of CO2, N2O and O2 seems to represent the best approach for reducing peritoneal inflammation due to pneumoperitoneum. However, these experimental data have not had a significant impact on the modification of laparoscopic instrumentation. In contrast, surgeons should train themselves to perform laparoscopy quickly, and they should complete their learning curves before testing chemical anti-adhesive agents and anti-adhesion barriers. Chemical anti-adhesive agents have the potential to exert broad peritoneal cavity protection against adhesion formation, but when these agents are used alone, the concentrations needed to prevent adhesions are too high and could cause major post-operative side effects. Anti-adhesion barriers have been used mainly in open surgery, but some clinical data from laparoscopic surgeries are already available. Sprays, gels, and fluid barriers are easier to apply in laparoscopic surgery than solid barriers. Results have been encouraging with solid barriers, spray barriers, and gel barriers, but they have been ambiguous with fluid barriers. Moreover, when barriers have been used alone, the maximum protection against ad

关键词： Peritoneal adhesions Laparoscopy Abdomen Gastrointestinal surgery Inflammation Learning curve Anti-adhesion Animal models clinical studies Laparoscopic resection of gastrointestinal

Implementation of the FAIR Data Principles for Exploratory Biomarker Data from clinical Trials

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Data Intelligence 2021年第4期3卷 630-661页

作者： Alexander Arefolov Laura Adam Shoshana Brown Yelena Budovskaya Cong Chen Diya Das Chen Farhy Rebecca Ferguson Hongmei Huang Kimberly Kanigel Christina Lu Oksana Polesskaya Tracy Staton Rajeev Tajhya Maryann Whitley Jee-Yeon Wong Xiangpei Zeng Mark McCreary Rancho BioSciences LLC. San DiegoCA 92127USA Development Sciences Informatics Genentech Inc.South San FranciscoCA 94080-4990USA Development Sciences OMNI-Biomarker Development Genentech Inc.South San FranciscoCA 94080-4990USA

The FAIR data guiding principles have been recently developed and widely adopted to improve the Findability,Accessibility,Interoperability,and Reuse of digital assets in the face of an exponential increase of data volume and *** FAIR data principles have been formulated on a general level and the technological implementation of these principles remains up to the industries and organizations working on maximizing the value of their ***,we describe the data management and curation methodologies and best practices developed for FAIRification of clinical exploratory biomarker data collected from over 250 clinical *** discuss the data curation effort involved,the resulting output,and the business and scientific impact of our ***,we propose prospective planning for FAIR data to optimize data management efforts and maximize data value.

关键词： Data management Data curation clinical studies FAIR data Biomarkers Data model Metadata Data standards Data governance

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Insight into generation of induced mesenchymal stem cells from induced pluripotent cells

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World Journal of Stem Cells 2022年第1期14卷 142-145页

作者： Mahmood S Choudhery Ruhma Mahmood Department of Biomedical Sciences King Edward Medical UniversityLahore 54000PunjabPakistan Department of Genetics and Molecular Biology University of Health SciencesLahore 54600PunjabPakistan Stem Cells Laboratory Allama Iqbal Medical CollegeLahore 54000PunjabPakistan

Mesenchymal stem cells(MSCs)have the potential for use in cell-based regenerative ***,hundreds of clinical trials are using MSCs for the treatment of various ***,MSCs are low in number in adult tissues;they show heterogeneity depending upon the cell source and exhibit limited proliferative potential and early senescence in in vitro *** factors negatively impact the regenerative potential of MSCs and therefore restrict their use for clinical *** a result,novel methods to generate induced MSCs(iMSCs)from induced pluripotent stem cells have been *** development and optimization of protocols for generation of iMSCs from induced pluripotent stem cells is necessary to evaluate their regenerative potential in vivo and in *** addition,it is important to compare iMSCs with primary MSCs(isolated from adult tissues)in terms of their safety and *** investigation of the properties of iMSCs in vitro and their long term behavior in animals is important for their translation from bench to bedside.

关键词： Induced mesenchymal stem cells Induced pluripotent stem cells Regenerative potential Pluripotent Multipotent clinical studies

clinical significance of TOAST typing of ischemic stroke in young adults

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Neural Regeneration Research 2007年第7期2卷 408-411页

作者： Jingli Liu Jinpin Li Department of Neurology First Affiliated Hospital Guangxi Medical University Nanning 530021 Guangxi Zhuang Autonomous Region China

BACKGROUND： Ischemic stroke in young adults brings extremely hurts for their families and society, and the etiological factors and risk factors are different in the world.OBJECTIVE： To analyze and evaluate clinical significance of ischemic stroke in young adults by using TOAST typing.DESIGN： Case analysis.SETTING： Department of Neurology, the First Affiliated Hospital, Guangxi Medical University.PARTICIPANTS： A total of 64 young adults with acute ischemic stroke were selected from the Department of Neurology, the First Affiliated Hospital, Guangxi Medical University from September 2005 to June *** were 44 males and 20 females and their age ranged from 15 to 45 years. All patients met with the diagnostic criteria of the Fourth National Cerebrovarscular Academic Meeting and certainly diagnosed with CT or MRI examination. In addition, all patients provided the confirmed consent.METHODS： ① TOAST typing： Based on X-ray of thoracic part, electrocardiography, blood routine, blood glucose, electrolure, lipid, blood coagulation test, anticardiolipin antibody, antinuclear antibody, anti-double chain DNA, antineutrophil cytoplasmic antibody, crook agglutination test, syphilis antibody and human immunodeficiency virus （HIV） antibody test, patients received TOAST typing, including large-artery atherosclerotic stroke （LA）, small-artery occlusion lacunar （SA）, cardioembolism （CE）, stroke of other demonstrated etiology （SOE）, and stroke of other undemonstrated etiology （SUE）. ② Risk factors： Stages of hypertension, diabetes mellitus, hyperlipemia, smoking and drinking of patients were observed. Blood pressure was measured twice after onset of acute stroke, and values of total cholesterol （TC） and/or triacylglycerol （TG） were measured more than twice to finally diagnose hyperlipemia. Diagnostic criteria of diabetes mellitus： fasting≥7.0 mmol/L; 2 hours after administrating glucose ≥ 11.1 mmol/L. Risk factor of smoking defined as more than 10 smokes every day in the

关键词： brain ischemia clinical studies risk factors

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Glucagon-like peptide-1 receptor agonists in non-alcoholic fatty liver disease: An update

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World Journal of Hepatology 2020年第8期12卷 493-505页

作者： Areti Sofogianni Athanasios Filippidis Lampros Chrysavgis Konstantinos Tziomalos Evangelos Cholongitas First Propedeutic Department of Internal Medicine Medical SchoolAristotle University of ThessalonikiAHEPA HospitalThessaloniki 54636Greece First Department of Internal Medicine Laiko General HospitalMedical School of National and Kapodistrian University of AthensAthens 11527Greece

Non-alcoholic fatty liver disease(NAFLD)is the predominant cause of chronic liver disease *** progresses in some cases to non-alcoholic steatohepatitis(NASH),which is characterized,in addition to liver fat deposition,by hepatocyte ballooning,inflammation and liver fibrosis,and in some cases may lead to hepatocellular *** prevalence increases along with the rising incidence of type 2 diabetes mellitus(T2DM).Currently,lifestyle interventions and weight loss are used as the major therapeutic strategy in the vast majority of patients with ***-like peptide-1 receptor agonists(GLP-1RAs)are used in the management of T2DM and do not have major side effects like *** patients with NAFLD,the GLP-1 receptor production is ***,several animal and human studies have emphasized the role of GLP-1RAs in ameliorating liver fat accumulation,alleviating the inflammatory environment and preventing NAFLD progression to *** this review,we summarize the updated literature data on the beneficial effects of GLP-1RAs in NAFLD/***,as GLP-1RAs seem to be an attractive therapeutic option for T2DM patients with concomitant NAFLD,we discuss whether GLP-1RAs should represent the first line pharmacotherapy for these patients.

关键词： Glucagon-like peptide-1 receptor agonists Non-alcoholic fatty liver disease Type 2 diabetes mellitus clinical studies Fatty liver Animal studies

Traditional Chinese medicine for age-related macular degeneration: A clinical evidence map between 2000 and 2022

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Science of Traditional Chinese Medicine 2023年第2期1卷 107-114页

作者： Yamin Li Lina Liang Yun Gao Kai Xu Wei Zhou Jiaxian Li Yu Jin Ziyang Huang Xiaoyu Li Eye Hospital China Academy of Chinese Medical SciencesBeijingChina Ophthalmology Project Team of China Center for Evidence Based Traditional Chinese Medicine BeijingChina

Background:We systematically searched and summarized clinical studies on traditional Chinese medicine(TCM)for age-relatedmacular degeneration(AMD)with the method of evidence *** aimed to provide evidence and research direction for the prevention or treatment of AMD with TCM in the *** and methods:We searched PubMed,Web of Science,EMBASE,and Chinese databases including CNKI(Chinese National Knowledge Infrastructure),WanFang and VIP,***,and Chineseclinical Trial Registry Center studies on the prevention or treatment of TCMfor AMD from January 2000 to November *** showed distribution features of these studies in the form of text description,graphs,and ***:The final 258 articles included 245 clinical studies,9 systematic reviews ormeta-analyses,and 4 guidelines,expert consensus,or clinical *** analyzing the articles with a focus on the stage of AMD,study type,sample size,intervention measures,outcome indicators,and the quality of evidence,we found that the studies were increasing,most of which were wet AMD,the main study type was randomized controlled trials,and the sample size was mostly fewer than 100 *** interventions of TCM,such as Chinese medicine,Chinese patentmedicine,or acupuncture,showed the potential benefits of improving vision,reducing fundus lesions,and alleviating some uncomfortable ***,the sample size of these studies was *** outcome indicators were not unified,and the stage of AMD was *** quality of articles was lower,and there were few studies on early *** advantages of TCM for the prevention or treatment of AMD remained ***:Early intervention will be the focus and direction of AMD in the prevention or treatment of TCM,and more standardized clinical studies of TCM for early AMD need to be designed and carried out in the future.

关键词： Age-related macular degeneration clinical studies Evidence map Traditional Chinese medicine

Immediate and Long Term clinical Benefits of a Novel Topical Micronized Collagen Face Cream

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Journal of Cosmetics, Dermatological Sciences and Applications 2022年第4期12卷 153-163页

作者： Rachel Lubart Anat Lipovsky Chemistry Department Bar Ilan University Ramat Gan Israel Physics Department Bar Ilan University Ramat Gan Israel Hava Zingboim Ltd. Ramat Gan Israel

Collagen has been a component of skin care formulations for many years, and over this time, there have been numerous claims of its efficiency. Collagen protein is responsible for firm strong skin, but since collagen fibers are too large to penetrate the stratum corneum (SC), topical creams containing collagen fibers remain on the skin surface without affecting skin quality. To overcome the poor penetration of collagen fibers, we prepared in the past micronized collagen fibers that were proven to reach the epidermis layer while inserted in a cream. In the present paper, we have performed a clinical study that analyzes the effect of the micronized fibrillar collagen containing cream on skin. Fifty five healthy female volunteers were enrolled and completed the study. The anti-ageing, firming, elasticity and moisturization efficacy of the cream were measured using Profilometer, Cutometer and Corneometer respectively. The results showed a significant improvement in skin hydration firmness and elasticity, a significant reduction in fine lines and wrinkles was also observed.

关键词： Micronized Collagen Face Cream clinical studies Skin Parameters Penetration