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Liquid biopsies for liquid tumors: emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies

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Cancer Biology & Medicine 2016年第2期13卷 215-225页

作者： Jay Hocking Sridurga Mithraprabhu Anna Kalff Andrew Spencer Myeloma Research Group Australian Center for Blood Diseases Monash University Malignant Haematology & Stem Cell Transplantation Service Alfred Hospital

circulating free nucleic acids; cell free DNA and circulating micro-RNA, are found in the plasma of patients with hematologic and solid malignancies at levels higher than that of healthy individuals. In patients with hematologic malignancy cell free DNA reflects the underlying tumor mutational profile, whilst micro-RNAs reflect genetic interference mechanisms within a tumor and potentially the surrounding microenvironment and immune effector cells. These circulating nucleic acids offer a potentially simple, non-invasive, repeatable analysis that can aid in diagnosis, prognosis and therapeutic decisions in cancer treatment.

关键词： circulating nucleic acids DNA miRNA hematologic malignancy biopsy

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Novel approaches in search for biomarkers of cholangiocarcinoma

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World Journal of Gastroenterology 2022年第15期28卷 1508-1525页

作者： Lavinia-Patricia Mocan Maria Ilieș Carmen Stanca Melincovici Mihaela Spârchez RareșCrăciun Iuliana Nenu Adelina Horhat Cristian Tefas Zeno Spârchez Cristina Adela Iuga Tudor Mocan Carmen Mihaela Mihu Department of Histology Faculty of Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania Department of Proteomics and Metabolomics MedFUTURE Research Center for Advanced Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400349Romania ^(nd)Pediatrics Department Faculty of Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania ^(rd)Medical Department Faculty of Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania Department of Gastroenterology "Prof.dr.Octavian Fodor"Institute for Gastroenterology and HepatologyCluj-Napoca 400162Romania Department of Pharmaceutical Analysis Faculty of Pharmacy"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania

Cholangiocarcinoma(CCA)arises from the ductular epithelium of the biliary tree,either within the liver(intrahepatic CCA)or more commonly from the extrahepatic bile ducts(extrahepatic CCA).This disease has a poor prognosis and a growing worldwide *** poor outcomes of CCA are partially explained by the fact that a final diagnosis is challenging,especially the differential diagnosis between hepatocellular carcinoma and intrahepatic CCA,or distal CCA and pancreatic head *** patients present with an advanced disease,unresectable disease,and there is a lack in non-surgical therapeutic *** least,there is an acute lack of prognostic biomarkers which further complicates disease ***,there is a dire need to find alternative diagnostic and follow-up pathways that can lead to an accurate result,either singlehandedly or combined with other *** the"-omics"era,this goal can be attained by various means,as it has been successfully demonstrated in other primary *** variants can reach a biomarker status ranging from circulating nucleic acids to proteins,metabolites,extracellular vesicles,and ultimately circulating tumor ***,given the relatively heterogeneous data,extracting clinical meaning from the inconsequential noise might become a tall *** current review aims to navigate the nascent waters of the non-invasive approach to CCA and provide an evidence-based input to aid clinical decisions and provide grounds for future research.

关键词： Cholangiocarcinoma Biomarker Proteomics Metabolomics Extracellular vesicles circulating nucleic acids

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circulating microRNAs as a liquid biopsy: a next generation clinical biomarker for diagnosis of gastric cancer

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 418-427页

作者： Shuhei Komatsu Jun Kiuchi Taisuke Imamura Daisuke Ichikawa Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKawaramachihirokojiKamigyo-kuKyoto 602-8566Japan First Department of Surgery Faculty of MedicineUniversity of YamanashiChuoYamanashi 409-3898Japan

Accumulating evidence has suggested the potential clinical utility of novel body fluid biomarkers,or“liquid biopsy”,using circulating tumor cells and cell-free nucleic acids from cancer *** and reproducible,liquid biopsy could provide the basis for individualized therapeutic strategies by identifying genetic and epigenetic aberrations that are closely associated with cancer initiation and ***(miRNAs)are short noncoding RNAs that post-transcriptionally regulate gene *** also play important roles in various physiological and developmental processes as oncogenic or tumor-suppressive *** miRNA expression signatures have been identified in a number of human *** miRNAs have been detected in plasma and serum,and this in blood has attracted the attention of researchers for their potential as noninvasive *** miRNAs have emerged as tumor-associated biomarkers that reflect not only the existence of cancer,but also the dynamics,malignant potential,and drug resistance of ***,we review the recent biological and clinical research on the circulating miRNAs of gastric cancer and discuss future perspectives for their clinical applications as a liquid biopsy.

关键词： Liquid biopsy circulating nucleic acids circulating microRNA biomarker gastric cancer

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