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Treatment effects and periodontal status of chronic periodontitis after routine Er:YAG laser-assisted therapy

World Journal of Clinical Cases 2021年第32期9卷 9762-9769页

作者： Yong-Zhi Gao Yan Li Shan-Shan Chen Bo Feng Hui Wang Qiao Wang Department of Stomatology The First Affiliated Hospital of Qiqihar Medical UniversityQiqihar 161041Heilongjiang ProvinceChina Department of Anatomy Basic Medical CollegeZunyi Medical UniversityZunyi 563006Guizhou ProvinceChina The Ward of Department of Ophthalmology and Torhinolaryngology The First Affiliated Hospital of Qiqihar Medical UniversityQiqihar 161041Heilongjiang ProvinceChina Department of Stomatology Qiqihar ENT HospitalQiqihar 161006Heilongjiang ProvinceChina Department of Stomatology The Second Affiliated Hospital of Qiqihar Medical UniversityQiqihar 161005Heilongjiang ProvinceChina

BACKGROUND Routine preclinical interventions for patients with chronic periodontitis such as supragingival cleaning and subgingival curettage,establishing a balanced occlusal relationship,and irrigation with 3%hydrogen peroxide can relieve the symptoms to some ***,there is room for improvement in the overall *** example,Er:YAG lasers can quickly increase the temperature of the irradiated tissue,effectively eliminate dental plaque and calculus,reduce periodontal pockets,adjust periodontal microecology,and reduce the gingival *** content of factors in the liquid,and then achieve the purpose of *** The aim was evaluate the effect of Er:YAG laser-assisted routine therapy on the periodontal status in chronic *** Between October 2018 and January 2020,106 patients with chronic periodontitis in our hospital were randomly assigned to either the study or control group,with 53 patients in each *** control group underwent routine therapy,and the study group underwent Er:YAG laser therapy in addition to routine *** evaluated the treatment outcome in both *** status was determined by clinical attachment loss(CAL),gingival index(GI),periodontal probing depth(PD),dental plaque index(PLI),and sulcular bleeding index(SBI),inflammatory factors in the gingival crevicular fluid,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),IL-8],and colony forming units(CFUs).RESULTS Total effectiveness in the study group(94.34%)was higher than that in the control group(79.25%,P0.05).However,after treatment,the parameters in the study group(PD,2.97±0.38 mm;CAL,2.71±0.64 mm;SBI,2.07±0.32;GI,0.51±0.11;PLI,1.29±0.34)were lower than those in the

关键词： Er:YAG laser therapy chronic periodontitis Periodontal status Oral inflammatory factors

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Role of salivary matrix metalloproteinase-8 （MMP-8） in chronic periodontitis diagnosis

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Frontiers of Medicine 2015年第1期9卷 72-76页

作者： Namita Gupta N.D. Gupta Akash Gupta Saif Khan Neha Bansa Department of Periodontics and Community Dentistry Dr. Z. A. Dental College Aligarh Muslim University Aligarh U.P. India Department of Biochemistry Rama Medical College and Hospital Pilakhua Hapur. U.P. India

periodontitis is an inflammatory disease of the periodontium. Any imbalance between the matrix metalloproteinases （MMPs） secreted by neutrophils and tissue inhibitors initiates the destruction of collagen in gum tissue, leading to chronic periodontitis. This study aimed to correlate salivary levels of MMP-8 and periodontal parameters of chronic periodontitis to establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis. The study involved 40 subjects visiting the periodontic OPD of Dr. Ziauddin Ahmad Dental College and Hospital, located in Aligarh, U.P., India, from 2011 to 2012. The subjects were divided into two groups： group I consisted of 20 periodontally healthy subjects （controls） while group II consisted of 20 patients with chronic periodontitis. chronic periodontitis was assessed on the basis of several periodontal parameters, including pocket probing depth （PPD）, clinical attachment level （CAL）, gingival index （GI）, and plaque index （PI）. Around 3 ml of unstimulated and whole expectorated saliva was collected for MMP-8 estimation by ELISA using Quantikine human total MMP-8 immunoassay kits. Data were analyzed using STATISTICA （Windows version 6） software. Salivary MMP-8 levels of groups I and II were 190.91 ± 143.89 ng/ml and 348.26± 202.1 ng/ml, respectively. The MMP-8 levels and periodontal status （PPD, CAL, GI, and PI） of groups I and II showed positive and significant correlations （for PPD, r = 0.63, P 〈 0.001; for CAL, r = 0.54, P 〈 0.001; for GI, r = 0.49, P 〈 0.001; and for PI, r = 0.63, P 〈 0.001）. The results of this study demonstrate elevated concentrations of MMP-8 in individuals with chronic periodontitis.

关键词： matrix metalloproteinase-8 chronic periodontitis pocket probing depth clinical attachment level gingival index plaque index

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Development and validation of a self-management ability questionnaire for patients with chronic periodontitis

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International Journal of Nursing Sciences 2019年第3期6卷 259-265页

作者： Chen Chen Xue Feng Yan-Ting Li Qi Zhang Ying-Shu Jin Tianjin University of Traditional Chinese Medicine TianjinChina Stomatological Hospital Tianjin Medical UniversityTianjinChina

Objective: This study aimed to develop and validate a self-management ability questionnaire for patients with chronic ***: A questionnaire was developed through theoretical research,literature review,semistructured interview,and expert consultation.A total of 231 patients with chronic periodontitis from the Department of Periodontics in the Stomatological Hospital of Tianjin Medical University were recruited by convenient *** and reliability were ***: The questionnaire consisted of 24 *** factor analysis identified three principal factors,which explained 66.949% of the total *** item-level content validity was between 0.800 and 1.000,and the scale-level content validity was *** coefficient of correlation between the gold standard and the whole questionnaire was ***'s α of the whole questionnaire was 0.931,and the test-retest reliability coefficient was ***: The questionnaire developed in this study satisfies the measurement standard and has good reliability and *** is useful for clinical work to measure self-management among patients with chronic periodontitis.

关键词： chronic periodontitis Oral health Self-management Surveys and questionnaires

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Nonsurgical periodontal-therapy improves glycosylated hemoglobin levels in pre-diabetic patients with chronic periodontitis

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World Journal of Diabetes 2017年第5期8卷 213-221页

作者： Rosamma Joseph Meera Sasikumar Jerry Mammen M G Joseraj Chandni Radhakrishnan Department of Periodontics Government Dental College Department of Biochemistry Government Medical College Department of Internal Medicine Government Medical College

AIM To evaluate the effect of nonsurgical periodontal therapy on glycosylated haemoglobin levels in pre-diabetic patients with chronic periodontitis(CHP).METHODS Sixty pre-diabetic patients with CHP were selected and equally allocated to case and control group. All subjects were evaluated at base line for periodontal parameters(plaque index, oral hygiene index, modified gingival index, probing pocket depth, clinical attachment level) and systemic parameters [glycosylated hemoglobin(HbA1c), fasting lipid profile, and fasting blood glucose]. The case group received non-surgical periodontal therapy. Subjects were re-evaluated for periodontal and systemic parameters after three *** Both groups were comparable at baseline. Three months after non surgical periodontal therapy(NSPT), there was significant improvement in periodontal parameters in case group. The mean difference in systemic parameters like HbA1c and fasting plasma glucose from baseline to fourth month for case group was 0.22 ± 0.11 and 3.90 ± 8.48 respectively and control group was-0.056 ± 0.10 and-1.66 ± 6.04 respectively, which was significant between case and control group(P < 0.05). In the case group there was a significant decrease in HbA1c from baseline to three months following NSPT(P < 0.05).CONCLUSION This study showed that periodontal inflammation could affect the glycemic control in otherwise systemically healthy individuals. Periodontal therapy improved periodontal health status and decreased glycosylated haemoglobin levels, thus reducing the probability of occurrence of inflammation induced prediabetes in patients with CHP.

关键词： Prediabetes chronic periodontitis Non surgical periodontal therapy

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Correlation of estrogen receptor alpha gene polymorphisms and bone mineral density in Chinese women with chronic periodontitis

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Chinese Medical Journal 2010年第22期123卷 3262-3267页

作者： ZHANG Xuan DAI Juan LONG Yin WU Hao LI Xiao-juan DING Yin Department of Orthodontics School of Stomatology Fourth Military Medical University Xi'an Shaanxi 710032 China Department of Traditional Chinese Medicine Fourth Military Medical University Xi'an Shaanxi 710032 China Laboratory of Bone Density Fourth Military Medical University Xi'an Shaanxi 710032 China Xijing Hospital Statistical Analysis Laboratory Fourth Military Medical University Xi'an Shaanxi 710032 China Department of Stomatology Chinese People's Liberation Army General Hospital Beijing 100853 China

Background periodontitis and osteoporosis are one of the frequently encountered diseases in post-menopausal women. Estrogen receptors （ERs） regulated bone metabolism. To investigate the possible effect of ER-elpha （a） gene polymorphisms on bone mineral density （BMD） in pre- and post-menopausal Chinese women with chronic periodontitis （CP）, we provided sufficient quantitative information concerning the correlation between ER gene polymorphisms and BMD in periodontitis. Methods Sixty-five post-menopausal and eighty pre-menopausal CP women, and sixty post-menopausal healthy individuals were recruited in this study. Genomic DNA was extracted from oral mucosa swab sample of each subject by the Chelex-100 method. Determination of the ER-a polymorphisms was performed by polymerese chain reaction-restriction fragment length polymorphism （PCR-RFLP） technique with Xbal and Pvull enzyme. The index for periodontal examination includes clinical attachment loss （CAL） and probing pocket depth （PPD）. BMD was measured by dual-energy X-ray absorptiometry （DEXA）. Results There were no significant differences between the ER-α genotypes of Pvull and Xbal and BMD in post-menopausal and pre-menopausal CP patients, respectively （P 〉0.05）. However, there was association between pre- and post-menopausal CP patients at BMD of lumbar spine L2-L4 （P=0.027） and Ward＇s BMD （P=0.004）. Furthermore, the post-menopausal CP women who carried Pvull TT genotype presented significantly lower Ward＇s BMD than the pre-menopausal CP women （P=-0.007）, meanwhile, the post-menopausal CP women who carried Xbal AA genotype presented significantly lower spine L2-L4 BMD than the pre-menopausal CP women （P=0.003）. Conclusions ER-α gene polymorphisms may be a susceptible indicator for BMD variation of lumbar spine L2-L4 and Ward in Chinese pre- and post-menopausal women patients with CP.

关键词： estrogen receptor-a gene polymorphisms chronic periodontitis bone mineral density pre-menopausal post-menopausal osteoporosis

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Effect of Plaque Control on chronic periodontitis in Psychiatric Patients with Long-term Hospitalization

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Chinese Journal of Biomedical Engineering(English Edition) 2021年第1期30卷 40-46页

作者： ZHOU Kai-qiang Department of Stomatology Xianyue Hospital in XiamenXiamen Fujian 361012China

Objective:To study the effect of plaque control on chronic periodontitis in psychiatric ***:116 psychiatric patients with chronic periodontitis in our hospital from March 2016 to April 2019 were selected as the research *** the patients were treated with ultrasonic curettage combined with minocycline hydrochloride ointment,and the patients were supervised to brush their teeth correctly every *** clinical treatment effect,detection of periodontal pathogens in subgingival plaque and gingival crevices were observed after *** levels of tumor necrosis facto-α(TNF-α),hypersensitive C-reactive protein(hs CRP)and interleukin-6(IL-6)in the fluid were measured,SBI were observed and ***:After the treatment,the levels of PG,Aa,Fn,Tf,Pi,Td,were significantly decreased,and the difference was statistically significant(Pchronic *** can improve the pathogenic bacteria in subgingival plaque and reduce the expression of inflammatory factors in the gingival crevicular fluid.

关键词： plaque control psychosis chronic periodontitis inflammatory factors

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Meta-analysis of the association between chronic periodontitis and chronic kidney disease

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World Journal of Clinical Cases 2024年第22期12卷 5094-5107页

作者： Fu Yang Cheng-Jun Shu Cai-Jun Wang Ke Chen Department of Stomatology Yuyao People’s Hospital of Zhejiang ProvinceYuyao 315400Zhejiang ProvinceChina

BACKGROUND Many scholars have performed several clinical studies have investigated the association between chronic periodontitis(CP)and chronic kidney disease(CKD).However,there are still differences between these research results,and there is no unified ***,a systematic review is required to understand this issue *** To explore the correlation between CP and *** Literature on the correlation between CP and CKD,as well as the clinical attachment level(CAL)and pocket probing depth(PPD)of CKD and non-CKD,were retrieved from PubMed,Embase,the Cochrane Library,and Web of Science repositories until January *** the effective data were extracted,data processing and statistics were performed using Stata *** Of the 22 studies,13 were related to CP and CKD,and 9 reported CAL and PPD in patients with CKD and healthy ***-analysis of the correlation between CP and CKD revealed that CKD probability in people with CP was 1.54 times that of healthy individuals[relative risk=1.54,95%confidence interval(CI):1.40-1.70],and CP incidence in patients with CKD was 1.98 times that of healthy individuals[overall risk(OR)=1.98,95%CI:1.53-2.57].Meta-analysis of CAL and PPD evaluations between CKD patients and healthy individuals showed that CAL and PPD levels were higher in CKD patients[standard mean difference(SMD)of CAL=0.65,95%CI:0.29-1.01;SMD of PPD=0.33,95%CI:0.02-0.63].CONCLUSION A bidirectional association exists between CP and *** risk is increased in CP patients and vice *** tissue or tooth loss risks increase over time in CKD patients.

关键词： chronic periodontitis chronic kidney disease Correlation Meta-analysis

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Effectiveness of Oral Care in Implant Denture Restoration in chronic periodontitis

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Journal of Clinical and Nursing Research 2024年第6期8卷 214-219页

作者： Jianli Zheng Hospital of Stomatology Xi'an Jiaotong University Xi'an 710004Shaanxi ProvinceChina

Objective:To explore the effect of observation of oral care in implant denture restoration of chronic ***:80 patients with chronic periodontitis implant denture restoration admitted from March 2022 to March 2023 in the hospital were *** were randomly divided into an observation group and a control group,with 40 cases in each *** groups of patients received routine treatment and *** patients in the control group used routine oral care methods to carry out oral care,the patients in the observation group carried out oral care on the basis of the control group,observation and analysis of the patients'mastery of oral knowledge,as well as the depth of the probing and the level of clinical ***:The oral knowledge mastery of the observation group was 72.31±6.98 after the nursing intervention,which was significantly higher than the score of 86.12±7.36 of the patients in the control group who used conventional oral care,and the difference was statistically significant at Pchronic ***,it is necessary to pay attention to the psychological counseling of the patients in the specific clinical application to ensure that the patients can actively cooperate with the clinical treatment.

关键词： Oral care chronic periodontitis Prosthetic restoration

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A Systematic Review and Meta-analysis on Adjunctive Effects of Nd:YAG Laser in chronic periodontitis:Evaluation of Clinical Periodontal Parameters

A Systematic Review and Meta-analysis on Adjunctive Effects ...

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作者： Puja Sharma 重庆医科大学

学位级别：硕士

BACKGROUND Various beneficial characteristics of laser such as ablation or vaporization,bactericidal,sterilization,bio stimulation and hemostatic effects have led to the potential application in periodontal *** The aim of present study is to broaden the present concept on Nd:YAG laser application adjunct to scaling and root planning in treatment of chronic periodontitis patients by systematically evaluating the available *** AND METHODS Extensive electronic and manual search on the relevant topic was done till end of August *** potential articles were reviewed by two individual reviewers and selected through consensus.A meta-analysis was conducted according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement and the Cochrane *** risk was evaluated according to Cochrane tool for risk of bias ***-analyses of the clinical attachment level gain(CAL),probing depth reduction(PD),gingival index(GI),Plaque index(PI),bleeding on probing(BOP)and gingival crevicular fluid(GCF)value were performed using weighted mean differences for continuous data with 95% confidence intervals in a random effect model in Revman *** Six potential publications were eligible for the systematic review out of which only five were included in *** to unclear risk of bias was detected,but heterogeneity was significant among *** statistical changes were detected in terms of PD(p=0.003),BOP(p=0.03)and GCF(pchronic ***,the available evidence is insufficient to implement adjunctive Nd:YAG laser as a definitive ***,further long term,well

关键词： Nd:YAG laser chronic periodontitis treatment non-surgical periodontal therapy systematic review

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Association of periodontal disease with glycemic control in patients with type 2 diabetes in Indian population

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Frontiers of Medicine 2017年第1期11卷 110-119页

作者： Palka Kaur Khanuja Satish Chander Narula Rajesh Rajputt Rajinder Kumar Sharma Shikha Tewari Department of Periodontics and Oral Implantology PGIDS Post Graduate Institute of Dental Sciences Rohtak Haryana 124001 India Department of Medicine Unit VII and Endocrinology PGIMS Post Graduate Institute of Medical Sciences Rohtak Haryana 124001 India

This study aims to investigate the link between glycated hemoglobin and diabetic complications with chronic periodontitis. A total of 207 patients with type 2 diabetes and chronic periodontitis （CP） were divided according to tertiles of mean PISA （periodontal inflamed surface area） scores as low, middle and high PISA groups. Simultaneously a group of 67 periodontally healthy individuals （PH） was recruited. Periodontal examinations, including full-mouth assessment of probing depths （PPD）, bleeding on probing, clinical attachment level and plaque scores were determined. Blood analyses were carried out for glycated hemoglobin （HbA1c）, fasting plasma glucose （FPG）, 2 h post parandial glucose （PPG）. Individuals in PH group had significantly better glycemic control than CP group. Upon one-way analysis of variance, subjects with increased PISA had significantly higher HbA1c levels, retinopathy and nephropathy （P 〈 0.05）. After controlling for age, gender, body mass index （BMI）, socioeconomic status （SES）, family history of diabetes and periodontitis, duration of diabetes, the mean PISA in mm^2, PPD 4-6 mm （%） and PPD ≥7 mm （%） emerged as significant predictors for elevated HbAlc in regression model （P 〈 0.05）. Logistic regression analysis revealed that PISA was associated with higher risk of having retinopathy and neuropathy （odds ratio）. In our study, the association between glycemic control and diabetic complications with periodontitis was observed.

关键词： type 2 diabetes mellitus hemoglobin A glycated chronic periodontitis

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