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Expression and significance of factors related to angiogenesis in choroidal melanoma

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International Journal of Ophthalmology(English edition) 2011年第1期4卷 49-54页

作者： Qiang Xu Gui-Qiu Zhao Jie Zhao Hong Lin Ying-Ying Mou Qing Wang and Wei-Rong Sun Department of Ophthalmology Affiliated Hospital of Qingdao University Medical Collage Qingdao 266003 Shandong Province China

AIM: To investigate expression of factors related to angiogenesis: HIF-1 alpha, iNOS, COX-2 and VEGF in choroidal melanoma and its clinical significance. METHODS: Fifty samples of choroidal melanoma and 15 samples of melanocytic nevi of the eyelid identified by pathology were collected. Immunohistochemistry SP method was used to examine the expression of HIF-1 alpha, iNOS, COX-2 and VEGF in these samples. The comparison among groups was done by SPSS 13.0 software. RESULTS: The positive expression rates of HIF-1 alpha, iNOS, COX-2 and VEGF in choroidal melanoma group were significantly higher than those in eyelid nevi group (chi(2)= 6.5542, 7.7224, 8.5828, 15.1749). The positive expression rate of VEGF was associated with the tumor size (chi(2)= 10.9194), but was not associated with pathological type (chi(2)=2.0712) and the situation of scleral invasion (chi(2)= 5.4289). The positive expression rate of HIF-1 alpha was associated with the tumor size (chi(2)=7.1216) and pathological type (chi(2)=9.0889), but was not associated with the situation of scleral invasion (chi(2)=3.3586). The positive expression rate of iNOS was associated with the tumor size (chi(2)=9.5503), but was not associated with pathological type (chi(2)=1.9450) and the situation of scleral invasion (chi(2)=2.3810). The positive expression rate of COX-2 was associated with the tumor size (chi(2)=7.2970), but was not associated with pathological type (chi(2)=1.8421) and the situation of sclera! invasion (chi(2)= 0.4018). The expression of HIF-1 alpha, iNOS and COX-2 were significantly associated with the expression of VEGF (r = 0.9429, 1, 0.9857). The expression of COX-2 was significantly associated with the expression of iNOS (r=0.9857). The expression of HIF-1 alpha was significantly associated with the expression of COX-2 ( r=0.9857). The expression of HIF-1 alpha was significantly associated with the expression of iNOS (r= 0. 9429). CONCLUSION: The expression of HIF-1 alpha, iNOS and COX-2 protein

关键词： choroidal melanoma immunohistoehemistry hypoxia inducible factor-1a inducible nitric oxide synthase cyclooxygenase-2

Complications from Plaque versus Proton Beam Therapy for choroidal melanoma: A Qualitative Systematic Review

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Journal of Cancer Therapy 2016年第3期7卷 169-185页

作者： Victoria L. Tseng Anne L. Coleman Zuo-Feng Zhang Tara A. McCannel Stein Eye Institute David Geffen School of Medicine at UCLA Los Angeles CA USA Department of Epidemiology UCLA Fielding School of Public Health Los Angeles CA USA

Plaque brachytherapy has been a mainstay of treatment for choroidal melanoma to achieve intraocular tumor control. The most common radioisotopes used for treating smaller sized tumors are Iodine-125 in North America and Ruthenium-106 in Europe. Proton beam radiotherapy is available at a few centers and may also be used to achieve local tumor control. Both plaque and proton beam therapy are known to be associated with a range of complications that may affect visual outcome and quality of life. These include radiation retinopathy, optic neuropathy, neovascular glaucoma and local treatment failure, requiring enucleation. While differences in the rates of these complications have not been well established in the literature for patients treated with plaque versus proton beam therapy for choroidal melanoma, certain geographic regions prefer one treatment modality over the other. The purpose of this qualitative systematic review was to compare and contrast reported complications that developed with plaque and proton beam therapy for the treatment of choroidal melanoma in studies published over a ten-year period. Reported rates suggest that patients with proton beam therapy had potentially higher rates of complications, including vision loss, enucleation, and neovascular glaucoma compared to those with plaque therapy. The rates of optic neuropathy, radiation retinopathy, and cataract formation were widely variable for the two treatment modalities and rates of metastasis and metastasis-free survival appeared similar with both treatments. The most common reported predictors of ocular complications following both types of therapy were tumor distance from the optic nerve, tumor thickness, and radiation dose, suggesting that inherent tumor characteristics play a role in visual prognosis.

关键词： choroidal melanoma Uveal melanoma Plaque Therapy Brachytherapy Proton Therapy Treatment Complications Metastasis Enucleation

Secondary endoresection for previously treated choroidal melanomas with a non-responsive course and persistent exudative retinal detachment

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 276-283页

作者： Ahmet Kaan Gündüz Ibadulla Mirzayev Department of Ophthalmology Ankara University Faculty of MedicineAnkara 06590Turkey Private Eye Clinic Ankara 06590Turkey Department of Ophthalmology Dünyagoz HospitalAnkara 06540Turkey

AIM:To evaluate the results and complications of secondary endoresection via pars plana vitrectomy for choroidal melanoma and review the previously reported endoresection studies on the treatment of choroidal ***:The medical records of 6 patients with choroidal melanoma who underwent secondary endoresection between March 2012 and March 2020 were retrospectively *** indications for secondary endoresection were progressive or recurrent tumor and severe exudative retinal detachment after previous treatment with plaque radiotherapy/Cyberknife radiosurgery/transpupillary thermotherapy(TTT).RESULTS:Before endoresection,2 eyes had Iodine-125 plaque radiotherapy and TTT,1 eye had Ruthenium-106 plaque radiotherapy and TTT,1 eye had Cyberknife radiosurgery and TTT,1 eye had Cyberknife radiosurgery,and 1 eye had TTT *** visual acuity ranged from 20/63 to 20/1600(Snellen) and from 0.5 to 1.9(mean:1.1) on the log MAR *** mean tumor base diameters were 9.5×8.7 mm and the mean tumor thickness was 5.4 *** secondary endoresection,transient vitreous hemorrhage developed in 2(33.3%) eyes and retinal detachment in 1(16.7%) *** examination revealed epithelioid cell melanoma in 4(66.7%) eyes and mixed cell melanoma in 1(16.7%).melanoma cell type was not specified in 1(16.7%) *** a mean follow-up of 49.6 mo(range:16-90 mo),mean visual acuity did not improve and 1 eye was enucleated due to tumor *** visual acuity ranged from 20/63 to 20/1600(Snellen) and from 0.5 to 1.9(mean:1.2) on the log MAR *** patients with choroidal melanoma developed metastasis and eventually ***:Secondary endoresection seems to be an effective treatment option for globe salvage in choroidal melanoma not responsive to conventional treatment and displaying persistent exudative retinal *** was no visual acuity increase among the treated eyes but globe salvage was possible in most cases in this study.

关键词： endoresection choroidal melanoma metastasis pars plana vitrectomy recurrence

Combination of oridonin and TRAIL induces apoptosis in uveal melanoma cells by upregulating DR5

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1834-1842页

作者： Xin Hua Peng Wu Guo-Sheng Gao Xiao-Lei Ye Department of Clinical Laboratory Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina Ningbo Institute of Life and Health Industry University of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina Department of Clinical Laboratory Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina College of Life Sciences China West Normal UniversityNanchong 637009Sichuan ProvinceChina

AIM:To investigate the inhibitory effect of the combined use of tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)and oridonin on choroidal melanoma cell lines,and to explore its underlying ***:MUM-2B and C918 cells were treated with different concentrations of TRAIL and oridonin,and MTT assay used to evaluate the inhibition rate of the two compounds on ***,the cell cycle distribution and apoptosis were detected by flow cytometry,and changes in apoptosis-related proteins such as death receptor 5(DR5),a-caspase-3,and x-linked inhibitor of apoptosis protein(XIAP)were detected by Western ***-2B cells were transfected with si-DR5,which interfered with the expression of the DR5 *** and Western blot assay were used to detect cell activity and apoptosis-related ***:When TRAIL and oridonin were simultaneously administered to the MUM-2B cells,the apoptosis rate was significantly higher than that by the two drugs ***,the effect of combined use of TRAIL and oridonin on C918 cells was not significantly different from that used *** cycle analysis showed that TRAIL and oridonin could induce G2/M arrest in MUM-2B *** Western blot results showed that the protein expression levels of the DR5,a-caspase-3,and BAX increased,while the expression levels of the anti-apoptosis-related proteins XIAP and BCL-2 were suppressed when TRAIL and oridonin simultaneously administered to MUM-2B *** the expression of DR5 gene in MUM-2B cells could reverse the inhibitory effect of oridonin and TRAIL on the proliferation and apoptosis induction of MUM-2B ***:The inhibitory effects of oridonin and TRAIL on MUM-2B cells are significantly enhanced when they were administered as a combined treatment,which may ascribe to up-regulation of DR5.

关键词： tumor necrosis factor-related apoptosisinducing ligand oridonin apoptosis choroidal melanoma