检索结果-南通市图书馆

Cancer risk in primary sclerosing cholangitis: Epidemiology,prevention, and surveillance strategies

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第6期25卷 659-671页

作者： Brian M Fung Keith D Lindor James H Tabibian UCLA-Olive View Internal Medicine Residency Program Olive View-UCLA Medical Center Office of the University Provost Arizona State University Division of Gastroenterology Department of MedicineOlive View-UCLA Medical Center

Primary sclerosing cholangitis(PSC) is a rare cholestatic liver disease characterized by progressive fibroinflammatory destruction of the intra-and/or extrahepatic biliary ducts. While its features and disease course can be variable,most patients with PSC have concurrent inflammatory bowel disease and will eventually develop liver cirrhosis and end-stage liver disease, with liver transplantation representing the only potentially curative option. Importantly,PSC is associated with a significantly increased risk of malignancy compared to the general population, mainly cholangiocarcinoma, gallbladder carcinoma,hepatocellular carcinoma, and colorectal cancer, with nearly 50% of deaths in patients with PSC being due to cancer. Therefore, robust surveillance strategies are needed, though uncertainty remains regarding how to best do so. In this review, we discuss the epidemiology, prevention, and surveillance of cancers in patients with PSC. Where evidence is limited, we present pragmatic approaches based on currently available data and expert opinion.

关键词： Bile duct diseases Cholangiocarcinoma Gallbladder carcinoma Hepatocellular carcinoma Colorectal cancer chemoprotection Inflammatory bowel disease

Perspective on dietary isothiocyanates in the prevention,development and treatment of cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2020年第1期6卷 271-286页

作者： Herman Yeger Reza Bayat Mokhtari The Hospital for Sick Children Program in Developmental and Stem Cell BiologyTorontoON M5G 0A4Canada Department Biomedical&Molecular Sciences Botterell Hall Rm 827Queen’s UniversityKingstonON K7L 3N6Canada

Epidemiological evidence has highlighted the association of specific diets and a lower incidence of ***,the Mediterranean diet provides high levels of polyphenolics and a high consumption of healthier fats,e.g.,as from olive *** the Mediterranean region the consumption of vegetables is elevated providing a class of compounds,the isothiocyanates(ITCs)as found in the cabbage *** ITCs have raised great interest for their health benefits over the past few *** of the key ITC compounds,sulforaphane,phenethylisothiocyanate and benzyl isothiocyanate,have been studied in vitro and in vivo and the data support their promise for cancer chemoprevention,as anti-tumor agents,and for chemoprotection of normal tissues and *** with other polyphenolic compounds in the diet,in general,they also possess key anti-inflammatory properties thus satisfying the criteria for compounds that could intervene in cancer initiation and *** this review we provide a larger overview of the advantages of including ITCs in the diet as food or as supplements and speculate on what could constitute a valuable therapeutic strategy for improving and sustaining good health and countering cancer disease in humans.

关键词： Mediterranean diet isothiocyanates chemoprevention chemoprotection anti-tumor hormesis mitohormesis anti-inflammatory

Low-Dose of the Sulforaphane Precursor Glucoraphanin as a Dietary Supplement Induces Chemoprotective Enzymes in Humans

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2015年第17期6卷 1603-1612页

作者： Yusuke Ushida Hiroyuki Suganuma Akinori Yanaka Research & Development Division Kagome Co. Ltd. Tochigi Japan Hitachi Medical Education and Research Center Faculty of Medicine University of Tsukuba Hospital Ibaraki Japan

Broccoli sprout (BS) supplements have been marketed for over a decade for the promising health beneficial effects of sulforaphane (SFN), which induces Nrf2 signaling and downstream chemoprotective genes, including phase 2 enzymes. Most commercially available BS supplements encapsulate heat-processed BS containing glucoraphanin (GR), which is hydrolyzed to SFN by the intestinal microbiota. However, the absorption behavior of SFN following the intake of such BS supplements is still unclear. Additionally, the GR dose (around 30 mg) recommended by many manufacturers of BS supplements is relatively lower than the effective dose determined in previous intervention studies. The aims of this study were to assess the effects of a single administration of a typical BS supplement containing lower doses of GR (30 or 60 mg from 3 or 6 capsules, respectively) on SFN absorption, and also to assess the serum activities of phase 2 enzymes as possible surrogate markers of the beneficial effects of SFN. Urinary excreted isothiocyanates and dithiocarbamates showed that the SFN absorption following administration of BS supplement was prolonged and varied among individuals, which conforms to the well-known characteristics of intestinal microbiota-mediated SFN absorption. The amount of SFN absorbed increased dose-dependently but not linear fashion (9.27 μmol and 13.5 μmol for 3 and 6 capsules, respectively). There was no significant difference in SFN bioavailability and the number of capsules consumed. Serum activities of phase 2 enzymes glutathione S-transferase (GST) and NAD(P)H: quinone oxidoreductase 1 (NQO1), which have been reported to display “chemoprotected states” in organs such as the liver, were dose-dependently and synchronously elevated (p < 0.05) following BS supplement intake. This suggests that a low dose of GR (30 mg) exerts chemoprotective effects in humans. In conclusion, our findings will be useful in future clinical studies investigating the chemoprotective effects of

关键词： Sulforaphane Glucoraphanin chemoprotection Broccoli Sprout Phase 2 Enzymes

Hesperidin Reduces Cisplatin-lnduced DNA Damage in Bone Marrow Cells of Mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmacy and Pharmacology 2017年第5期5卷 282-288页

作者： Tatiane da Silva Passos Esdras Andrade Santana Maina Mantovanelli da Mota Jean Carlos Vencioneck Dutra Juliana Macedo Delarmelina Maria do Carmo Pimentel Batitucci Departamento de Ciencias Biologieas Universidade Federal do Espirito Santo Vitoria 29075-91 Brazil

Hesperidin is a bioflavonoid abundantly found in citrus fruits and displays chemoprotective effects against DNA （deoxyribonucleic acid） damage, however there are few reports about hesperidin effects against cisplatin-DNA damage induction. The aim of this work was to evaluate hesperidin antimutagenicity against cisptatin-DNA damage. （1） The antimutagenicity of hesperidin was assayed by bone marrow of mice in vivo using the micronucleus test. Hesperidin pre-treatment protocol reduced the frequency of MNPCE （micronucleated polychromatic erythrocytes） and the dose of 100 mg·kg-1 was highest efficiency, with 65.24% of damage reduction. In the simultaneous treatment protocol, the dose of 200 mg·kg-1 exhibited a more effective reduction of MNPCE, with 94.01% of damage reduction. （2） Hesperidin was also effective in reducing the MNPCE frequency in the post-treatment protocol for all doses, with 77.48%, 82.13% and 90.08% of damage reduction at the doses of 100, 200 and 400 mg·kg-1, respectively. From the study, it can be concluded that hesperidin was able to promote the reduction of micronuclei frequency and DNA damage induced by cisplatin. Hesperidin is a powerful antioxidant compound and its chemoprotective effects on DNA may occur due to its association with the antioxidant cell system which is responsible for eliminate free radicals generated by chemical harmful to DNA.

关键词： Hesperidin micronucleus test DNA damage chemoprotection antimutagenicity.

Does a melatonin supplement alter the course of gastroesophageal reflux disease?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pharmacology and Therapeutics 2011年第6期2卷 50-51页

作者： Mariusz H Madalinski NHS Lothian-University Hospitals Division Edinburgh EH1 4SAUnited Kingdom Department of Gastroenterology Western General HospitalCrewe Road SouthEdinburgh EH4 2XUUnited Kingdom

Symptomatic gastro-esophageal reflux disease(GERD) is a very common *** consequence of GERD is not only erosive esophagitis,but also esophageal stricture,Barrett's esophagus and extra-esophageal damage(including the lungs,throat,sinuses,middle ear and teeth).GERD and Barrett's esophagus are also identif ied as major risk factors for esophageal *** with melatonin prevents esophageal injury from acid-pepsin and acid-pepsin-bile exposure in animals,then further studies are required in humans to establish whether a melatonin supplement is able to protect the patients with GERD from erosions,Barrett's and neoplasia.

关键词： Gastro-esophageal reflux disease Melatonin chemoprotection Barrett’s