Does a melatonin supplement alter the course of gastroesophageal reflux disease?

作     者：Mariusz H Madalinski 

作者机构：NHS Lothian-University Hospitals DivisionEdinburgh EH1 4SAUnited Kingdom Department of GastroenterologyWestern General HospitalCrewe Road SouthEdinburgh EH4 2XUUnited Kingdom 

出 版 物：《World Journal of Gastrointestinal Pharmacology and Therapeutics》 (世界胃肠药理与治疗学杂志（英文版）（电子版）)

年 卷 期：2011年第2卷第6期

页      面：50-51页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Gastro-esophageal reflux disease Melatonin Chemoprotection Barrett’s 

摘      要：Symptomatic gastro-esophageal reflux disease(GERD) is a very common *** consequence of GERD is not only erosive esophagitis,but also esophageal stricture,Barrett s esophagus and extra-esophageal damage(including the lungs,throat,sinuses,middle ear and teeth).GERD and Barrett s esophagus are also identif ied as major risk factors for esophageal *** with melatonin prevents esophageal injury from acid-pepsin and acid-pepsin-bile exposure in animals,then further studies are required in humans to establish whether a melatonin supplement is able to protect the patients with GERD from erosions,Barrett s and neoplasia.