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chemical constituents and ACE inhibitory activity of desert plant Suaeda physophora Pall.

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Acta Pharmaceutica Sinica B 2013年第5期3卷 328-332页

作者： Ruizhi Men Ning Li Yachao Xing Yingzhan Tang Chengyu Tan Fantong Meng Juan Zhang Hui Ni Xiaoguang Jia Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education School of Traditional Chinese MedicineShenyang Pharmaceutical UniversityShenyang 110016China Marine Environmental Engineering College Dalian Ocean UniversityDalian 116023China Xinjiang Institute of Chinese Materia Medica and Ethnodrug Urumqi 830002China

Suaeda physophora *** a kind of desert plant mostly growing in saline habitats in Xinjiang Uygur Autonomous *** order to have a better utilization of halophytes,a screening for ACE inhibitors from halophytes growing in Xinjiang was carried *** result showed that the 70%EtOH extract and n-BuOH extract of *** *** significant ACE inhibitory *** we focused on its biochemical constituents *** new quinazoline alkaloid,namely Suaedine(1),along with six known compounds(2–7)was isolated from the aerial parts of *** *** structure of the new quinazoline alkaloid was established by one-and two-dimensional nuclear magnetic resonance,optical rotation and mass spectrometry *** flavonoid compounds(2–4)and phenolic compound(5)exhibited significant ACE *** was the first time to focus on the chemical constituents and bioactivities of this plant.

关键词： Desert plant Suaeda physophora Pall. chemical constituents ACE inhibitory activity

chemical constituents from aerial parts of Scoparia dulcis

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Chinese Herbal Medicines 2023年第1期15卷 151-154页

作者： Yingbo Yang Zhuzhen Han Tong Tian Qi Liao Jiaran Geng Ying Xiao The SATCM Key Laboratory for New Resources&Quality Evaluation of Chinese Medicine Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Jiangsu Kanion Pharmaceutical Co. Ltd.Lianyungang 222000China

Objective: To study the chemical constituents from the aerial parts of Scoparia ***: Various chromatographic techniques were used to separate the constituents and their structures were elucidated using spectroscopic methods and by comparing their data to those reported in the literatures. The α-glucosidase inhibitory activity assay was used to identify potential α-glucosidase ***: Nine compounds were isolated from the aerial parts of S. dulcis. Their structures were identified as Scoparic zolone(1),(2S)-2,7-dihydroxy-2H-1,4-benzoxazin-3(4H)-one(2),(2R)-7-hydroxy-2H-1,4-benzoxazin-3(4H)-one-2-O-β-D-glucopyranoside(3),(2R)-7-methoxy-2H-1,4-benzoxazin-3(4H)-one-2-O-β-D-glucopyranoside(4),(2S)-7-hydroxy-2H-1,4-benzoxazin-3(4H)-one-2-O-β-D-glucopyranoside(5),6-methoxy-benzoxazolin-2(3H)-one(6), 4-acetonyl-3,5-dimethoxy-p-quinol(7), zizyvoside I(8), and3,4-dihydroxy benzeneacetic acid(9). Compound 2 showed the potent α-glucosidase inhibitory activity with an IC50value of(132.8 ± 11.5) μmol/L, which is 28-fold higher than the positive control ***: Compound 1 is a new natural product. Compounds 2 and 9 have not been reported in Scoparia before. Compounds 3, 5, 7, 8 are isolated from Scrophulariaceae for the first time.

关键词： alkaloids chemical constituents α-glucosidase inhibitory activity Scoparia dulcis L.

Analysis and Identification of the chemical constituents of Ding-Zhi-Xiao-Wan Prescription by HPLC-IT-MSn and HPLC-Q-TOF-MS

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Chinese Journal of Chemistry 2015年第4期33卷 451-462页

作者： Shiyao Tang Shu Liu Zhiqiang Liu Fengrui Song Shuying Liu Changchun Center of Mass Spectrometry&chemical Biology Laboratory Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunJilin 130022China University of Chinese Academy of Sciences Beijing 100039China

Ding-Zhi-Xiao-Wan(DZXW)is a famous traditional Chinese medicine(TCM)formula,which is composed of four herbs,Ginseng Radix,Poria,Polygala Radix and Acori Tatarinowii *** has been popularly used for the treatment of emotional disease,like Alzheimer’s disease,Parkinson’s disease,depression,anxiety,forgetfulness and *** this research,a high-performance liquid chromatography coupled with ion-trap tandem mass spectrometry(HPLC-IT-MS^(n))method along with a high-performance liquid chromatography coupled with quadru-pole time-of-flight mass spectrometry(HPLC-Q-TOF-MS)method in negative ion mode was established to inves-tigate the major constitutions in *** extracts were prepared by ultra-sonication in ethyl acetate,n-butanol,95%ethanol and deionized water sequentially as well as in deionized water directly.A Kromasil C18 column was used to separate the extracts of *** and 0.1%aqueous formic acid(V/V)were used as the mobile phase.A total of 64 components were characterized,including 16 triterpenoids,14 Polygala saponins,10 oligosac-charide esters,6 sucrose esters,2 xanthone C-glycosides and 16 ginsenosides.

关键词： Ding-Zhi-Xiao-Wan chemical constituents HPLC-IT-MSn HPLC-Q-TOF-MS

The chemical constituents from red alga Gymnogongrus flabelliformis Harv.

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Chinese Journal of Oceanology and Limnology 2008年第2期26卷 190-192页

作者：袁兆慧韩丽君苏华史大永孙杰李帅石建功 Institute of Oceanology Chinese Academy of Sciences Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

Eight compounds were isolated from red alga Gymnogongrus flabelliformis Harv. In normal phase silica gel, Sephadex LH-20 gel column chromatography, reverse phase HPLC, and recrystallization. Based on MS and ID NMR spectroscopic data, their structures were determined as： stigmast-4-en-3-one （Ⅰ）, cholest-4-en-3-one （Ⅱ）, cholesterol （m）, uracil （Ⅳ）, uridine （V）, adenosine （Ⅵ）, succinic acid （Ⅶ）, and 5-hydroxy-4-methyl-5-pentyl-2,5-dihydro-furan-2-on （Ⅷ）. All of them were obtained from this species for the first time. Cytotoxicity of these compounds was screened using standard MTT method, but all the compounds were inactive （IC50 〉 10 μg/ml）.

关键词： red algae Gymnogongrus flabelliformis Harv. chemical constituents MTT assay

The chemical constituents of the tissue culture cells of Daphne giraldii cullus

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Chinese chemical Letters 2009年第11期20卷 1335-1338页

作者： Zhao Hua Wu Li Bo Wang Hui Yuan Gao Jian Huang Bo Hang Sun Shu Hui Li Li Jun Wu School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China Department of Pharmacology Mudanjiang Medical College Mudanjiang 157001 China

Three compounds were isolated from the tissue culture cells of Daphne giraldii cullus, their structures were identified as daphneolone （1）, S-（＋）-1-（4-hydroxy-3-methoxyphenyl）-3-hydroxy-5-phenyl-l-pentanone （2）, S-（＋）-1-（4-methoxyphenyl）-3- hydroxy-5-phenyl-l-pentanone （3）, and among them, 2 was a new compound, 3 was a novel natural product.

关键词： Tissue culture cells Daphne giraldii cullus chemical constituents Structural identification

Advances in research on chemical constituents and pharmacological effects of Paecilomyces hepiali

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Food Science and Human Wellness 2021年第4期10卷 401-407页

作者： Akang Dan Yujia Hu Ruyan Chen Xiangyang Lin Yongqi Tian Shaoyun Wang School of Biological Science and Technology Fuzhou UniversityFuzhou 350108China

Paecilomyces hepiali is a fungus with edible and pharmaceutic value,isolated from Ophiocordyceps *** main bioactive constituents contain alkaloids,cyclic dipeptides,steroids,organic acids,and *** to the huge development potential of *** in the field of food and medicine,it has been developed into a variety of products that cater to the needs of the *** this paper,the chemical constituents and their pharmacological effects of *** are reviewed,which can provide reference for the development and application of ***.

关键词： Paecilomyces hepiali chemical constituents Pharmacological effects

A critical review on chemical constituents and pharmacological effects of Lilium

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Food Science and Human Wellness 2019年第4期8卷 330-336页

作者： Pengyu Wang Jian Li Fatma Alzahra K.Attia Wenyi Kang Jinfeng Wei Zhenhua Liu Changqin Li National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China School of Food Science and Engineering Hefei University of TechnologyHefei 23009China Department of Ornamental Medicinal and Aromatic PlantsFaculty of AgricultureAssiut University71515Egypt Joint International Research Laboratory of Food&Medicine Resource Function Henan ProvinceKaifeng 475004China

Genus Lilium is famous for edible and medicinal function which is related to its chemical constituents and pharmacological *** researches showed that genus Lilium genus mainly contains steroidal saponins,polysaccharides,alkaloids and *** effects of Lilium include anti-tumor,hypoglycemic,antibacterial,anti-oxidation,anti-depression and *** paper summarized chemical constituents and pharmacological effects of Lilium.

关键词： Lilium chemical constituents Pharmacological effects

Lobelia chinensis: chemical constituents and anticancer activity perspective

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Chinese Journal of Natural Medicines 2014年第2期12卷 103-107页

作者： CHEN Mei-Wan CHEN Wen-Rong ZHANG Jin-Ming LONG Xiao-Ying WANG Yi-Tao State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macao School of Traditional Chinese Medicine Guangdong Pharmaceutical University

Research has demonstrated that many chemical constituents dominated by piperidine alkaloids and flavonoids, such as lobelanidine, lobeline, and lobelanine, have been obtained from Lobelia chinensis Lour. Experimental studies and clinical applications have also indicated that L. chinensis possesses a number of pharmacological activities(e.g., diuretic, choleretic, breathing excitement, anti-venom, anti-bacterial, and anticancer). This paper focuses on the properties, chemical constituents, and anticancer activity of L. chinensis to clarify the connection among them, and identify the active anticancer compounds. This work serves as the foundation for further research and development of L. chinensis.

关键词： Lobelia chinensis chemical constituents Anticancer activity

chemical constituents from the stem of Embelia laeta

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Journal of Chinese Pharmaceutical Sciences 2022年第4期31卷 264-269页

作者： Jingling Tan Juan Lu Guohua Zheng Hubei Engineering Research Center for Drug Qualltiy Control Hubei Institute for Drug ControlWuhan 430075China School of Pharmacy Hubei Universtiy of Chinese MedicineWuhan 430065China Xiangyang Public Inspection and Testing Center Xiangyang 441104China

In the present study,we aimed to investigate the chemical constituents from Embelia *** constituents were separated by various column chromatography,including silica gel,ODS gel,MCI gel,Sephadex LH-20,and semipreparative *** structures were elucidated by spectroscopic means.A total of 13 compounds were isolated from *** and identified as(6R,9R)-1-Oxo-α-ionol-9-O-β-D-goucopyranoside(1),(+)-Pinoresinol(2),Leptolepisol D(3),Kaempferol(4),Kaempferol-3-α-L-Ramnopyranoside(5),Kaempferol-3-β-D-(6-O-trans-p-coumaroyl) glucopyranoside(6),Bis(2-ethylhexyl) phthalate(7),2-Benzenedicarboxylic diisobutyl ester(8),Caffeic acid methyl ester(9),Paldehyde(10),Coniferaldehyde(11),Caffeic acid(12)and 5-Hydroxymethyl furfural(13),*** the compounds were isolated from *** for the first time.

关键词： Embelia laeta chemical constituents Structural identification