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CSF S100B in patients treated by endovascular coiling or surgical clipping after aneurysmal subarachnoid hemorrhage and its correlation to cerebral vasospasm

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Chinese Neurosurgical Journal 2017年第4期3卷 192-197页

作者： Ruiyan Li Jianlong Li Qingbin Li Qinghua Yuan Minghui Chen Yan Feng Yongli Li Xiaoyan Lu Zhongfei Hao Mingli Liu Jinquan Cai Chuanlu Jiang Department of Neurosurgery the 2nd Affiliated Hospital of Harbin Medical University (HMU) Harbin 150086 China Department of Neurosurgery the 2nd Affiliated Hospital of Harbin Medical University (HMU) Harbin 150086 ChinaChinese Glioma Cooperative Group (CGCG) Beijing 100050 ChinaArthroplasty Center of Nanfang Hospital Southern Medical UniversityGuangzhou 510515 China Department of Neurology the 2nd Affiliated Hospital of HMU Harbin 150086 China Department of Neurosurgery the 2nd Affiliated Hospital of Harbin Medical University (HMU) Harbin 150086 ChinaNeuroscience InstituteAcademy of Medical Sciences in Heilongjiang Harbin 150086 ChinaChinese Glioma Cooperative Group (CGCG) Beijing 100050 China

Background: Aneurysmal subarachnoid hemorrhage (aSAH) is an acute neurosurgical emergency with a significant fatality rate. In addition to acute brain injury, a considerable part of patients suffering from aSAH develops secondary brain damage such as cerebral vasospasm (CVS). CVS exacerbates the mortality. Therefore, it is urgently needed to find a biomarker, which could predict secondary brain and lead to operation by physicians more promptly. S100B, produced and released by astrocytes, has proven to be an important biomarker for brain ***: In this present study, 51 patients with aSAH were included. Five CSF samples from each patient were obtained via lumbar puncture and were detected using electrochemiluminescence immunoassay (ECLIA).Results: It indicated that S100B had a higher concentration in CSF of patients treated by surgical clipping after aSAH than that treated with endovascular coiling. In addition, the mean CSF S100B level in patients without CVS was much lower compared with patients with CVS. And, the expression of S100B increased along with the Fisher Grade at the same day after aSAH attacked and decreased as time went on. Moreover, the CSF S100B level of different time points and the mean CSF S100B level can predict the risk of ***: These data suggest that CSF S100B can be served as a predictor of CVS, which triggers an immediate management by clinicians to prevent secondary exacerbation.

关键词： Aneurysmal subarachnoid hemorrhage S100B Surgical clipping Endovascular coiling cerebral vasospasm

Drug treatment of cerebral vasospasm after subarachnoid hemorrhage following aneurysms

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Chinese Neurosurgical Journal 2016年第2期2卷 -页

作者： Yongfei Liu HanCheng Qiu Juan Su WeiJian Jiang The New Era Stroke Care and Research Institute The Second Artil ery General Hospital PLA Beijing 100088 China

cerebral vasospasm (CVS) is a common and severe complication of aneurysmal subarachnoid hemorrhage (aSAH). Despite the improvement in treatment of aSAH, CVS complicating aSAH has remained the main cause of death. CVS begins most often on the third day after the ictal event and reaches the maximum on the 5th–7th postictal days. Several therapeutic modalities have been employed to prevent or reverse CVS. The aim of this review is to summate all the available drug treatment modalities for vasospasm.

关键词： cerebral vasospasm Subarachnoid hemorrhage Aneurysms Drug treatment

INFLUENCE OF GINKGO BILOBA EXTRACT ON NITRIC OXIDE AND ENDOTHELIN-1 DURING cerebral vasospasm IN RATS

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Chinese Medical Sciences Journal 2003年第3期18卷 189-193页

作者：孙保亮张苏明夏作理杨明峰邱平明 Department of Neurology Tongji HospitalTongji Medical Collegeof Huazhong Universityof Scienceand Technology Wuhan 430030 Department of Neurology Affiliated Hospitalof Taishan Medical College Taian271000

*** investigate the effects of Ginkgo biloba extracton cer ebral vasospasmafter subarachnoid hemorrhageand its influence on n itric oxideand endothelin-l .*** models of SAH in Wistar rats were used and animals were divided into sham-operated group ,SAH group,saline-treated group and EGb-treated *** of basilar a rtery was *** cerebral blood flow,NO and ET-1levels in blood,and calcium content in brain tissue within24hours after SAH were dete *** examination of hippocampus CA1sub-field was also performed .*** operation did not alter the above *** of SAH l ed to a marked spasm of basilar *** decreased obviously and consecutive ly within24hours after *** NO level in serum decreased,ET-1level in plasma and calcium content in brain tissue significantly *** midal cells in hippocampus CA1subfield were severely *** significantly antago-nized the pathological alterations of the above *** .Alterations of NO,and ET-1play an important role in the development of CV S after *** exerts its protective effects on CVS by inhibitng the above pat hological alterations.

关键词： subarachnoid hemorrhage cerebral vasospasm Ginkgo biloba

Identification of OPN, TNC and E-selectin as potential recognition proteins in cerebral vasospasm after subarachnoid hemorrhage

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Chinese Neurosurgical Journal 2016年第3期2卷 -页

作者： Min Jun Wei Jiu Geng Feng Zhi Qun Jiang Chun Hui Zeng Li Ping Jiang Tao Hong Deparment of Neurosurgery the First Affiliated Hosptial Nanchang University Yong wai zheng Street 6 Nanchang Jiangxi Province 330006People's Republic of China Department of Pharmacology School of Pharmacy Nanchang University461 Bayi Avenue Nanchang Jiangxi Province 330006 People's Republic of China

Background:cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) is a serious and significant health problem in the *** are still no effective therapies for treatment of CVS in patients suffering from *** early studies have demonstrated that the expression of connexin43 (Cx43,a member of gap junctional proteins) in cerebral spastic vessel is significantly up-regulated,and knocking down Cx43 with specific siRNA interference can significantly alleviate CVS after ***,Cx43 in cerebral vessel is a potential target in the treatment of ***,Cx43 is widely distributed in many organs,particularly in the heart,and plays an important role in the physiological *** study is aimed at identify whether OPN,TNC or E-selectin can be used as a target protein to be recognized in spastic cerebral vessels,then we can produce a carrier containing Cx43 siRNA or other inhibitors as a new potential treatment for ***:Twenty eight male Sprague Dawley rats (weighing 300-350 g) were randomly divided into either SAH (n =16) or sham group (n =12).The double hemorrhage model was performed on day 0 and *** animals were sacrificed after performing India ink angiography on day ***,the expression of E-selectin,TNC and OPN in cerebral arteries,thoracic aorta and abdominal aorta were analyzed respectively by immunohistochemical staining,western blot in both ***,only those with less expression in thoracic aorta,abdominal aorta and normal cerebral arteries,but higher expression in cerebral spastic arteries were further detected in the spinal cord,heart,kidney,liver,spleen,lung,pancreas,mesenteric and pulmonary arteries,retina and brain tissue,***:TNC,OPN and E-selectin were markedly elevated in the spastic cerebral arteries in SAH group but not in control *** expression of TNC,but not OPN and E-selectin,is abundant in both groups of thoracic aorta and abdominal *** study demonstrated that expression

关键词： cerebral vasospasm Gap junctional Cx43 OPN E-selectin Targeting protein

Research on the pathogenesis of cerebral vasospasm following subarachnoid hemorrhage

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白求恩医科大学学报 2000年第5期26卷 519-522页

作者： Liu Baiyun Wang Chungcheng Wu Zhongxue Wu Jianzhong Dept.of Neurosurgery Beijing Tiantan HospitalBeijing100050China

目的 :进一步研究脑血管痉挛的发生机理 ,为临床治疗服务。方法 :采用 1 4只成年家犬 ,实验组 9只 ,对照组 5只 ,通过 2次枕大池注血法建立蛛网膜下腔出血 (SAH)模型。观察痉挛血管的自由基变化、血管活性、血管造影像、超微结构变化。... 详细信息

目的 :进一步研究脑血管痉挛的发生机理 ,为临床治疗服务。方法 :采用 1 4只成年家犬 ,实验组 9只 ,对照组 5只 ,通过 2次枕大池注血法建立蛛网膜下腔出血 (SAH)模型。观察痉挛血管的自由基变化、血管活性、血管造影像、超微结构变化。另外 2 0只犬用来观察血管扩张剂的作用。结果 :实验组较对照组自由基含量高 ,血管活性降低 ,血管狭窄 ,管壁损害重。结论 :尼莫地平对急性痉挛有效 ,对慢性痉挛无效 ;慢性血管痉挛是以管壁结构性狭窄为特点。

关键词： subarachnoid hemorrhage cerebral vasospasm nimodipine pathogenesis

Clinical Efficacy of Shenmai Injection in the Treatment of cerebral vasospasm after Ruptured Aneurysm Surgery

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Case Reports in Clinical Medicine 2021年第10期10卷 253-263页

作者： Tianya Wu Jingxin Fu Xinghuo Jin Qichao Chen Huanming Huang Shiqi Chen Junan Zhou Longbiao Xu Department of Neurosurgery Zhuji Affiliated Hospital of Shaoxing University Zhuji People’ Hospital of Zhejiang Province Zhuji China Department of Chinese Medicine Zhuji Yaojiang Town Central Health Center of Zhejiang Province Zhuji China The Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine Zhuji China

Objective: To investigate the therapeutic effect of Shenmai Injection on postoperative cerebral vasospasm in patients with ruptured aneurysms. Methods: Seventy patients undergoing craniotomy for ruptured aneurysms in our hospital were selected as study subjects and randomly divided into control (n = 33) and research (n = 37) groups, they were treated with nimodipine and nimodipine combined with Shenmai injection after operation. The blood flow velocity in the middle cerebral artery (MCA) before and at 1, 3, 7, 11 and 14 days after surgery and the incidence of cerebral vasospasm during these days were compared, and the GCS scores at 14 days postoperatively and GOS scores at 6 months postoperatively were compared between the two groups. Results: There were no statistically significant differences in the occurrence of cerebral vasospasm, GCS or GOS scores between the two groups (P > 0.05), but the period of postoperative cerebral vasospasm in the study group was significantly shorter than that in the control group. Conclusion: Shenmai injection has the effect of shortening the cycle of occurrence of cerebral vasospasm after the operation of ruptured aneurysms, promoting patients to recover as early as possible and reducing their physical and mental burden.

关键词： Shenmai Injection Nimodipine Ruptured Aneurysm Aneurysmal Subarachnoid Hemorrhage cerebral vasospasm

New Developments in Drug Therapy and Research of cerebral vasospasm

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Open Journal of Modern Neurosurgery 2013年第4期3卷 72-93页

作者： Eleftherios Archavlis Peter Ulrich Mario Carvi YNievas Department of Neurosurgery Sana Klinikum OffenbachAkademisches Lehrkrankenhaus der UniversitatFrankfurtGermany Department of Neurosurgery Klinikum TraunsteinAkademisches Lehrkrankenhaus der UniversitatMünchenGermany

In this manuscript a comprehensive coverage of recent developments in the drug therapy of vasospasm while providing the background information that neuroscientists need to understand its rationale. The range of new agents available for treatment of cerebral vasospasm is expanding rapidly along with rapid advances in pharmacology and physiology that are uncovering the mechanisms of this disease. Although there are many publications for treatment of cerebral vaso-spasm, most are focusing on different aspects of vasospasm treatment and many have limited value due to insufficient quality. Moreover, the complexity of this, in many cases deleterious condition, is enormous and the information needed to understand drug effects is accordingly often not readily available in a single source. A number of pharmacological and medical therapies are currently in use or being investigated in an attempt to reverse cerebral vasospasm, but only a few have proven to be useful. Current research efforts promise the eventual production of new medical therapies. At last, recommendations for the use of different treatment stages based on currently available clinical data are provided.

关键词： cerebral vasospasm Drug Therapy Subarachnoid Hemorrhage Delayed cerebral Ischemia New Developments Treatment

The effect of ecdysterone on cerebral vasospasm following experimental subarachnoid hemorrhage in vitro and in vivo

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The effect of ecdysterone on cerebral vasospasm following ex...

The Beneficial Effect of Hydrogen-Rich Saline on cerebral vasospasm after Experimental Subarachnoid Hemorrhage in Rats

中国医师协会神经外科医师分会第二届全国代表大会

作者： TANG Wei-hua LIU Zhi ZHANG John H XI Guo-hua CHEN Zhi FENG Hua Department of Neurosurgery,Southwest Hospital,Third Millitary Medical University,Chongqing. 重庆西南医院神经外科

＜正＞Objectives cerebral vasospasm was the dread complication of a raptured intracranial *** effort has led to many promising experimental treatments but none were confirmed to be effective in clinical *** is a kind of insect steroid *** previous study showed that ecdysterone might prevent CVS in *** after all these studies,rare attempts have been made to test the effect of Eedysterone on VAFs,a processes known to play an important role in various pathogenic vascular conditions. Thus,we tested the hypothesis that Eedysterone could affect VAF’s characteristic and do effect in SAIl induced cerebral *** 100μM OxyHb were used in the in vitro study to mimic the clinical situation,the effects of OxyHb on cells proliferation and migratio of cultured aortic smooth muscle cells was *** the in vivo study,20 rabbits were equally divided into 4 groups:control group,SAH group,SAH/Nimodipine group and SAH/ecdysterone *** of neurological function and cerebral angiogram of rabbits were observed after *** OxyHb increased the proliferation of VAFs at *** co-treatment was something like to suppress *** cycle analysis indicated that EDS inhibited vascular advential fibroblasts from G1 to S *** of migration assay showed that 100 μM OxyHb obviously prompt vascular advential fibroblasts migration and EDS would attenut this *** SAH/Nimodipine and SAH/ecdysterone groups,neural deficit, cerebral vasospasm and structural changes in basilar artery were alleviated with Nimodipine or ecdysterone *** Ecdysterone could affect VAF’s characteristic and attenuate vasospasm after SAH.

关键词： cerebral vasospasm Ecdysterone Oxyhemoglobin Rabbit animal model Vascular advential fibroblasts

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The Beneficial Effect of Hydrogen-Rich Saline on Cerebral Va...