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Vitamin D deficiency and increased inflammatory factor intercellular cell adhesion molecule-1 indicate severe leukoaraiosis in northern China

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Frigid Zone Medicine 2024年第2期4卷 102-109页

作者： Jiaxin Guan Lu Gan Chaoqi Yan Boyu Hou Ying Fan Second Affiliated Hospital of Harbin Medical University Harbin 150081China The Physical examination center of the Second Affiliated Hospital of Harbin Medical University Harbin 150081China

Background and objective:Commonly plaguing in the frigid zone of the world,vitamin D deficiency,as indicated by low levels of 25-hydroxyvitamin D,exacerbated inflammatory responses and impaired endothelial ***(LA)is a prevalent cause of cognitive dysfunction in the elderly and is potentially associated with inflammatory *** study aimed to investigate the impact of vitamin D on the severity of ***:Patients with LA were categorized based on 3.0 T brain MRI findings into mild(N=43),moderate(N=40),or severe groups(N=29)using the Fazekas scale(scoring 1-6).A control group consisting of 41 healthy individuals was *** fibrinogen C,homocysteine,plasma 25-hydroxyvitamin D,and intercellular cell adhesion molecule-1(ICAM-1)levels were measured using ***:All LA severity groups exhibited lower plasma 25-hydroxyvitamin D levels compared to the control group,with a more pronounced decrease observed as LA severity *** plasma 25-hydroxyvitamin D was identified as an independent risk factor for LA(Pvascular inflammatory factor ***:disease severity positively correlated with levels of the inflammatory marker ICAM-1,worsening as plasma 25-hydroxyvitamin D concentration *** 25-hydroxyvitamin D emerged as an independent risk factor for LA,potentially exacerbating the inflammatory *** findings suggest 25-hydroxyvitamin D supplementation as a potential therapeutic approach for LA.

关键词： cerebral small vascular disease degenerative disease leukoaraiosis white matter hyperintensities lacunar infarction 25-hydroxyvitamin D ICAM-1 fibrinogen-C inflammatory factor fazekas scale

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