Vitamin D deficiency and increased inflammatory factor intercellular cell adhesion molecule-1 indicate severe leukoaraiosis in northern China
作者机构：Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China The Physical examination center of the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China
出 版 物：《Frigid Zone Medicine》 (寒地医学（英文）)
年 卷 期：2024年第4卷第2期
页 面：102-109页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of Heilongjiang Province of China(No.LH2020H051) Key R&D projects of Natural Science Foundation of Heilongjiang Province(No.2023ZX06C03) Foundation of Harbin Science Technology Bureau of China(No.2014RFQGJ042)
主 题：cerebral small vascular disease degenerative disease leukoaraiosis white matter hyperintensities lacunar infarction 25-hydroxyvitamin D ICAM-1 fibrinogen-C inflammatory factor fazekas scale
摘 要：Background and objective:Commonly plaguing in the frigid zone of the world,vitamin D deficiency,as indicated by low levels of 25-hydroxyvitamin D,exacerbated inflammatory responses and impaired endothelial ***(LA)is a prevalent cause of cognitive dysfunction in the elderly and is potentially associated with inflammatory *** study aimed to investigate the impact of vitamin D on the severity of ***:Patients with LA were categorized based on 3.0 T brain MRI findings into mild(N=43),moderate(N=40),or severe groups(N=29)using the Fazekas scale(scoring 1-6).A control group consisting of 41 healthy individuals was *** fibrinogen C,homocysteine,plasma 25-hydroxyvitamin D,and intercellular cell adhesion molecule-1(ICAM-1)levels were measured using ***:All LA severity groups exhibited lower plasma 25-hydroxyvitamin D levels compared to the control group,with a more pronounced decrease observed as LA severity *** plasma 25-hydroxyvitamin D was identified as an independent risk factor for LA(P0.05)according to Multiple logistic regression ***,a negative association was observed between 25-hydroxyvitamin D and vascular inflammatory factor ***:Disease severity positively correlated with levels of the inflammatory marker ICAM-1,worsening as plasma 25-hydroxyvitamin D concentration *** 25-hydroxyvitamin D emerged as an independent risk factor for LA,potentially exacerbating the inflammatory *** findings suggest 25-hydroxyvitamin D supplementation as a potential therapeutic approach for LA.
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