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Electrochemically and DNA-triggered cell release from ferrocene/β-cyclodextrin and aptamer modified dual- functionalized graphene substrate

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Nano Research 2015年第3期8卷 887-899页

作者： Lingyan Feng Wen Li Jinsong Ren Xiaogang Qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China University of Chinese Academy of Sciences Beijing 100039 P. R. China

Here we report a dual-functionalized electrochemical substrate to trigger cancer cells release based on the supramolecular interaction between β-cyclodextrin （β-CD） and Fc on clinical trial II aptamer AS1411 functionalized graphene platform. On one hand, the host-guest interaction can be reversible electrochemically controlled to realize cancer cells capture/release, and 1-adamantylamine binding can further amplify this surface change by competing interaction with β-CD. On the other hand, the AS1411 aptamer and its complementary DNA （cDNA） also can be used as a switchable anchor for cell adhesion. Our work gives an example for label-free, multi-functionalized triggered cell release based on aptamer and β-CD/graphene-modified surface and this multi-ways for cell catch-and-release on graphene modified surface also provides their potential biomedical application.

关键词： cell release ferrocene/β-cyclodextrin AS1411 graphene

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Biphenyl-Induced Superhelix in L-Phenylalanine-Based Supramolecular Self-Assembly with Dynamic Morphology Transitions

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CCS Chemistry 2022年第8期4卷 2816-2828页

作者： Laiben Gao Yueyue Feng Chao Xing Yu Zhao Meng Sun Yunqing Zou Changli Zhao Xiaoqiu Dou Chuanliang Feng State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240 College of Chemistry and Materials Science Shanghai Normal UniversityShanghai 200234 School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001

Dynamic transitions of supramolecular assemblies between lower-order structures and higher-order superhelical structures(e.g.,double-helical DNA,helical biopolymers)are of vital importance in many physiological processes,but still remain a great challenge to be realized in artificially assembled ***,a novel biphenyl central core symmetrically coupled with phenylalanine groups drives the construction of the dynamic superhelix.

关键词： superhelix biphenyl chirality morphological transition cell release

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Delivering MC3T3-E1 cells into injectable calcium phosphate cement through alginate-chitosan microcapsules for bone tissue engineering

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第4期15卷 382-392页

作者： Peng-yan QIAO Fang-fang LI Li-min DONG Tao XU Qiu-fei XIE Department of Prosthodontics Peking University School and Hospital of Stomatology Beijing Key Lab of Fine Ceramics Institute of Nuclear and New Energy TechnologyTsinghua University Department of Preventive Dentistry Peking University School and Hospital of Stomatology National Engineering Laboratory for Digital and Material Technology of Stomatology Peking University School and Hospital of Stomatology

Objective： To deliver cells deep into injectable calcium phosphate cement（CPC） through alginate-chitosan（AC） microcapsules and investigate the biological behavior of the cells released from microcapsules into the ***： Mouse osteoblastic MC3T3-E1 cells were embedded in alginate and AC microcapsules using an electrostatic droplet *** two types of cell-encapsulating microcapsules were then mixed with a CPC ***3T3-E1 cell viability was investigated using a Wst-8 kit,and osteogenic differentiation was demonstrated by an alkaline phosphatase（ALP） activity *** attachment in CPC was observed by an environment scanning electron ***： Both alginate and AC microcapsules were able to release the encapsulated MC3T3-E1 cells when mixed with CPC *** released cells attached to the setting CPC scaffolds,survived,differentiated,and formed mineralized *** grew in the pores concomitantly created by the AC microcapsules in situ within the *** Day 21,cellular ALP activity in the AC group was approximately four times that at Day 7 and exceeded that of the alginate microcapsule group（P0.05）.Pores formed by the AC microcapsules had a diameter of several hundred microns and were spherical compared with those formed by alginate ***： AC microcapsule is a promising carrier to release seeding cells deep into an injectable CPC scaffold for bone engineering.

关键词： Injectable scaffold Calcium phosphate cement Osteoblast Microencapsulation cell release Chitosan

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