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Cytotoxic effect of methanolic extracts of Fritillaria imperialis bulbs and Eryngium caucasicum leaves on hepatoma and colon cancer cells

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Asian Pacific Journal of Tropical Biomedicine 2019年第8期9卷 353-358页

作者： Mostafa Kardan Zahra Yazdani Zaher Morsaljahan Mohammad Ali Ebrahimzadeh Alireza Rafiei Student Research Committee Department of ImmunologyMolecular and cell Biology Research CenterSchool of MedicineMazandaran University of Medical SciencesSariIran Department of Immunology School of MedicineMazandaran University of Medical SciencesSariIran Pharmaceutical Sciences Research Center Department of Medicinal ChemistryFaculty of PharmacyMazandaran University of Medical SciencesSariIran

Objective: To evaluate antitumor activities of Fritillaria imperialis and Eryngium caucasicum methanolic extracts on human hepatoma (HepG2) and colon cancer (HCT116) cell lines in comparison to human foreskin fibroblasts as the normal cells. Methods: Methanolic extracts of Fritillaria imperialis and Eryngium caucasicum were prepared by the maceration method. The effect of the extracts at various concentrations (100, 200, 400, 600, and 800 μg/mL) on cell survival was evaluated using the MTT method. Besides, fluorescence staining was used to evaluate death patterns of the cells. Results: MTT assay showed that Fritillaria imperialis significantly decreased the viability of all cell lines after 24 and 48 hours of treatments. However, Eryngium caucasicum extract did not show any significant cytotoxicity effect on the cell lines. Fluorescence staining revealed that Fritillaria imperialis induced apoptosis of HCT116 cells at 550 μg/mL. Conclusions: Fritillaria imperialis extract has antiproliferative and cytotoxic effects on HCT116 and HepG2 cancer cells and therefore, may serve as an anticancer agent.

关键词： Fritillaria imperialis Eryngium caucasicum Cytotoxity Colon cancer Hepatoma cancer

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