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Effects of decline in renal function with age on the outcome of asymptomatic carotid plaque in healthy adults： a 5-year follow-up study

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Chinese Medical Journal 2012年第15期125卷 2649-2657页

作者： JIANG Shi-min SUN Xue-feng GU Hong-xia CHEN Yun-shuang XI Chun-sheng QIAO Xi CHEN Xiang-mei Department of Nephrology Chinese People's Liberation ArmyGeneral Hospital State Key Laboratory of Kidney Disease Beijing100853 China

Background It has been long suggested that abnormal clinical factors in the body, such as dyslipidemia and diabetes, can affect the presence of atherosclerosis. However, few studies on the effect of factors within the normal range, such as the loss of renal function with age, on the prevalence of atherosclerosis are few know in healthy individuals. The aim of this study was to investigate risk factors affecting the presence of asymptomatic carotid plaques in a middle-aged and elderly healthy population. Methods In this regard, we prospectively evaluated 245 healthy individuals （98 males and 147 females） at baseline and after 5 years. Changes in the presence of carotid plaque between 2003 and 2008 were categorized into four groups, i.e. subjects without plaque at entry （n=165）： Group 1 （without plaque on two occasions, n=129） and Group 2 （with nascent plaque at follow-up, n=36）; subjects with plaque at entry （n=80）; Group 3 （with plaque regression at follow-up, n=29） and Group 4 （with plaque on two occasions, n=51）. Results Univariate analysis showed that the positive rate of carotid plaques in males was higher than that in females at the baseline, and that a significantly inverse correlation existed between the prevalence rate of plaque and aging. Logistic regression analysis of cross-sectional research showed that independent risk factors for the prevalence of atherosclerosis were male gender, lower estimated glomerular filtration rate （eGFR） and higher low-density lipoprotein cholesterol （LDL-C） at the baseline, and older age and lower eGFR were involved in the presence of carotid plaques at follow-up point. However, logistic regression analysis of the longitudinal data showed that older age, decreased eGFR and increased systolic blood pressure （SBP） independently predicted the presence of carotid plaques after 5 years in subjects without plaque at entry. In addition, in subjects with plaque at entry, age, changes in eGFR and the baseline levels of serum albumin （

关键词： carotid plaque estimated glomerular filtration rate, risk factors epidemiology

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Relationship between Levels of Serum C-Reactive Protein,Leucocyte Count and carotid plaque in Patients with Ischemic Stroke

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2003年第3期23卷 263-265页

作者：郭毅姜昕周志斌陈实赵宏文李富康 Department of Neurology

In order to study the relationship between serum C-reactive protein (CRP) levels, leukocyte count and carotid plaque in patients with ischemic stroke, carotid duplex examination was performed by high-definition imaging (HDI) 5000 triplex system. Serum CRP was measured by nephelometry within 72 h after index ischemic stroke. A lesion was considered a plaque in the presence of a maximum intimal-medial wall thickness (IMT) 1.2 mm. Results of carotid ultrasonography were divided into two groups: M1, normal (IMT carotid plaque in patients with acute cerebral infarction.

关键词： C-reactive protein ischemic stroke leukocyte carotid plaque

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Study on the Correlation between the Characteristics of carotid plaque and Ischemic Stroke

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Chinese Journal of Biomedical Engineering(English Edition) 2019年第3期28卷 93-104页

作者： WANG Qian LIU Si-bo LONG An-ni LIU Jing-zhe ZHANG Xiao-wei LI Lei Department of Vascular Surgery and Radiology the First Affiliated Hospital of Tsinghua UniversityBeijing 100016China

Objective:To evaluate the correlation between MRI plaque characteris-tics and ischemic stroke in patients with carotid artery stenosis≤50%.Methods:From September 2014 to February 2016,43 patients with carotid artery plaque with stenosis less than or equal to 50%were selected by *** patients were examined by black blood *** correlation between MRI plaque characteristics and other risk fac-tors and ischemic stroke was evaluated by single factor and multi factor ***:The median follow-up time of all patients was 11.8 *** Meier survival analy-sis showed that the median time of stroke free was significantly shorter in patients with intracoronary hemorrhage than in patients without intracoronary hemorrhage,which was 14.3 months and 18.6 months,respectively(P=0.001);the median time of stroke free was also significantly shorter in patients with coronary heart disease than in patients without coronary heart disease,which was 12.1 months and 18.7 months,respectively(P=0.029).Cox regression analysis showed that coronary heart disease(HR=27.4;95%CI,1.6-464.3;P=0.022)and intraplaque hemorrhage(HR=18.2;95%CI,2.7-123.3;P=0.003)were inde-pendent risk factors for ischemic ***:In the patients with carotid artery stenosis≤50%,plaque hemorrhage and coronary heart disease are independent risk factors of ischemic stroke.

关键词： carotid plaque ischemic stroke bleeding in plaque coronary heart disease magnetic resonance imaging

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Evaluation of carotid plaque neovascularization in patients with coronary heart disease using contrast-enhanced ultrasonography

Evaluation of carotid plaque neovascularization in patients ...

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中国超声医学工程学会第十四届全国超声心动图学术会议

作者： Chuan Qin Li Zhang Xinfang Wang Yilian Duan Zhou Ye MingxingXie Department of Ultrasound Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Hubei Province Key Lab of Molecular Imaging

Objective:To examine the the repeatability of the TIC quantitative analysis software in the micro blood perfusion of neovascularization within carotid plaques by contrast-enhanced ultrasonography(CEUS).To investigate carotid plaque neovascularization in patients with coronary heart disease(CHD) using CEUS,and the correlation between the risk factors and acute coronary syndrome(ACS).Method:A total of 60 ACS patients and 60 stablecoronary artery disease(SCAD) patients were selected to undergo conventional carotid ultrasonography and CEUS,and the plaque enhancement was observed and analyzed *** inclusive criteria were matched with 2003 American Heart Association criteria for *** CEUS was performed in relation to the ACS occur within one *** using a II-generation contrast agent,SonoVue(sulphur hexafluoride microbubbles surrounded by a phospholipid shell).Interobserver and intraobserver variability of the measurements was assessed.A is the maximum number of microbubblesthat local tissues could accumulate,reflecting the local microvascular density and representing the capillary ***:The ACS group presented higher low-density lipoprotein cholesterol(LDL-C)(3.21±0.75 &2.53±0.71,Pplaques in the ACS group(72%) was higher than that in the SCAD *** proportion of plaque enhancement,intensity of plaque enhancement(A) and ratio of enhancement intensity in the plaque to that in the carotid lumen in the ACS group were higher than those in SCAD *** A value was correlated with the hs-CRP value;the sensitivity and specificity of A value were80.0%and 88.3%,*** regression analyses indicated that age(65-74 years),hs-CRP and A were correlated with the occurrence of *** sensitivity and specificity of the A value of carotid plaques were 80.0%and 88.3%,respectively,(the cut-off valuewas 9.97 dB

关键词： contrast-enhanced ultrasoungraphy carotid plaque neovascularization acute coronary syndrome

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基于Transformer 和双注意力机制的颈动脉超声造影图像斑块分割方法

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建模与仿真 2024年第2期13卷 1577页

作者：王金生孙占全上海理工大学光电信息与计算机工程学院，上海

脑卒中是一项重大的公共卫生挑战，同时也是全球导致死亡人数最多的疾病之一。颈动脉粥样硬化斑块与脑卒中等缺血性疾病密切相关。颈动脉斑块的早发现和早治疗对预防未来缺血性脑卒中疾病的发生具有重要意义。超声造影(CEUS)已经成为常... 详细信息

脑卒中是一项重大的公共卫生挑战，同时也是全球导致死亡人数最多的疾病之一。颈动脉粥样硬化斑块与脑卒中等缺血性疾病密切相关。颈动脉斑块的早发现和早治疗对预防未来缺血性脑卒中疾病的发生具有重要意义。超声造影(CEUS)已经成为常见的诊断颈动脉斑块的成像方式，因此从CEUS图像中准确分割动脉粥样硬化斑块对于预防和治疗缺血性脑卒中至关重要。然而，由于斑块边界模糊和图像噪声强烈等原因，CEUS图像颈动脉斑块自动分割面临巨大挑战。因此，如何提高颈动脉斑块分割性能仍然是迫切需要解决的问题。本文提出了一种创新的医学图像分割框架，称为DATU-Net，该框架将Swin Transformer模块和双注意力机制集成到U形架构中，以实现CEUS图像颈动脉斑块自动分割。DATU-Net采用基于Swin Transformer模块构建的编码器，可以有效地建模远程依赖关系和多尺度上下文信息。为了获得更丰富的特征表示，我们在编码器–解码器的跳跃连接中引入了双级注意力(Dual-Level Attention)模块，以增强图像特定的位置特征和通道特征，从而有效提高了斑块分割性能。此外，我们在解码器中引入了Swin Transformer模块，用于进一步探索上采样过程中的全局上下文信息，同时逐步恢复特征图。我们利用实际的临床数据集对提出的框架性能进行了评估。广泛的实验仿真结果显示，本文提出的方法在Dice系数(0.8548)、交并比(0.7632)、精确度(0.8746)和召回率(0.8863)等方面始终优于其他分割网络。这些实验证明了DATU-Net的有效性，为颈动脉超声造影图像斑块自动分割问题提供了一种可行的解决方案。

关键词：颈动脉斑块超声造影医学图像分割 Swin Transformer 双注意力机制 carotid plaque Contrast-Enhanced Ultrasound Medical Image Segmentation Swin Transformer Dual Attention Mechanism

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Significance of Increased CIMT with Coexisting carotid plaques in Cerebral White Matter Lesions in Elders

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2013年第1期33卷 69-74页

作者：舒敏章军建董燕张在鹏 Department of Neurology Zhongnan HospitalWuhan University Department of Mathematics and Statistics University of New Mexico Department of Radiology Zhongnan HospitalWuhan University

It is very common that increased carotid intima media thickness （CIMT） and carotid plaque coexist in a single subject in elderly patients with white matter lesions （WMLs）. In this study we inves- tigated whether the coexistence of increased CIMT and carotid plaque is more strongly associated with the presence and extent of WMLs than either alone. All patients were classified into 1 of the following 4 groups： without either increased CIMT （I） or carotid plaque （P）： I（-）P（-）; with only increased CIMT： I（＋）P（-）; with only carotid plaque： I（-）P（＋）; and with both increased CIMT and carotid plaque： I（＋）P（＋） The presence and severity of periventricular WMLs （PWMLs） and deep WMLs （DWMLs） were as- sessed and the prevalence of MRI findings by the Cochran-Armitage trend test was calculated. The characteristics of subjects showed that the percentages of patients with increased CIMT and carotid plaque in the DWMLs group and the PWMLs group were significantly higher than those without WMLs group. Both DWMLs and PWMLs were strongly associated with age, carotid plaque and CIMT. Furthermore, the Cochran-Armitage trend test indicated that the prevalence of MRI findings of PWMLs and DWMLs increased in the order of I（-）P（-）〈 I（＋）P（-）〈 I（-）P（＋）〈 I（＋）P（＋）（P〈0.0001）. For the pa- tients with DWMLs, the grades of both I（＋）P（-） and I（＋）P（＋） were increased significantly compared to I（-）P（-）（P〈0.0025, P〈0.05, respectively） without such a difference found in patients with PWMLs. Our results suggested that the coexistence of increased CIMT and carotid plaque is most closely associated with WMLs, and that increased CIMT is associated with the severity of DWMLs, whereas carotid plaque is related to the presence of WMLs.

关键词： carotid intima media thickness carotid plaque deep white matter lesions periventricular white matter lesions

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Correlation of Enhancement Degree on Contrast-enhanced Ultrasound with Histopathology of carotid plaques and Serum High Sensitive C-Reactive Protein Levels in Patients Undergoing carotid Endarterectomy

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2017年第3期37卷 425-428页

作者：熊莉孙伟军蔡华英杨园朱江赵博文 department of medical ultrasound sir run run shaw hospitalzhejiang universityHangzhou 310016China department of neurosurgery sir run run shaw hospitalzhejiang universityHangzhou 310016China department of neurology sir run run shaw hospitalzhejiang universityHangzhou 310016China

This study was undertaken to investigate the correlation of the enhancement degree on contrast-enhanced ultrasound(CEUS) with the histopathology of carotid plaques and the serum high sensitive C-reactive protein(hs-CRP) levels in patients undergoing carotid endarterectomy(CEA). carotid CEUS was performed preoperatively in 115 patients who would undergo CEA, and the enhancement degree of the carotid plaques was evaluated by both the visual semiquantitative analysis and the quantitative time-intensity curve analysis. Serum hs-CRP levels were detected using the particle-enhanced immunoturbidimetric assay also before the operation. Additionally, the carotid plaque samples were subjected to histopathological examination postoperatively. The density of neovessels and the number of macrophages in the plaques were assessed by immunohistochemistry. The results showed that among the 115 patients, grade 0 plaque contrast enhancement was noted in 35 patients, grade 1 in 48 patients and grade 2 in 32 patients. The degree of plaque enhancement, the density of neovessels, the number of macrophages, and the hs-CRP levels were highest in the grade 2 patients. Correlation analysis showed that the enhancement degree of the carotid plaques was closely related to the immunohistochemical parameters of the plaques and the serum hs-CRP levels. It was suggested that the carotid plaque enhancement on CEUS can be used to evaluate the vulnerability of carotid plaques.

关键词： carotid plaque neovascularization contrast-enhanced ultrasound carotid endarterectomy high sensitive C-reactive protein

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Association between Fundus Atherosclerosis and carotid Arterial Atherosclerosis

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International Journal of Clinical Medicine 2023年第5期14卷 282-289页

作者： Ting Wang Xiaoqian Xu Ruifang Xiang Juan Wang Xiaoqin Liu Health Management Center Deyang People’s Hospital Deyang China

Objective: To investigate the correlation between fundus atherosclerosis and carotid arterial atherosclerosis. Methods: A total of 516 people undergoing physical examination in Deyang People’s Hospital between June 2020 and December 2022 were randomly selected. Fundus atherosclerosis and carotid arterial atherosclerosis were evaluated by fundus photography and carotid artery ultrasonography, respectively. Results: Among the 516 physical examination patients, 198 (38.4%) had normal fundus examination, and 318 (61.6%) had fundus arteriosclerosis. Among them, 166 cases were of grade I (32.2%), 86 cases were of grade II (16.7%), and 66 cases were of grade III (12.8%). There were 286 cases (55.4%) without carotid atherosclerosis, 201 cases (38.9%) with carotid atherosclerotic plaque, and 33 cases (6.4%) with carotid stenosis. Fundus arteriosclerosis is independently associated with carotid artery intima-media thickness, vulnerable plaques, plaque scores, and carotid artery stenosis (P Conclusion: In summary, there is a close relationship between carotid artery disease and the degree of arteriosclerosis in the eyeground. Fundus photography is a simple, non-invasive, and easily acceptable method of inspection. The results obtained from it are useful in determining the severity of carotid atherosclerosis and guiding early detection and intervention in clinical cases. This can help reduce the incidence of cardiovascular and cerebrovascular diseases.

关键词： carotid Arterial Atherosclerosis Fundus carotid plaque carotid Stenosis Ultrasonography

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