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carotid atherosclerosis and Cognitive Impairment in Nonstroke Patients

Chinese Medical Journal 2017年第19期130卷 2375-2379页

作者： Wei-Hong Chen Wei Jin Pei-Yuan Lyu Yang Liu Rui Li Ming Hu Xiang-Jian Xiao Graduate School Hebei Medical University Shijiazhuang Hebei 050017 China Department of Neurology Hebei General Hospital Shijiazhuang Hebei 050051 China

Objective： As a vascular risk factor, carotid atherosclerosis is crucial to cognitive impairment. While carotid intima-media thickness, carotid artery plaque, and carotid stenosis can reflect carotid atherosclerosis in different stages, this review aimed to explore researches on the role of carotid intima-media thickness, carotid artery plaque, and carotid stenosis in the progress of cognitive impairment in nonstroke patients and tried to illustrate the possible mechanisms. Data Sources： We searched the PubMed database for recently published research articles up to July 2017, with the key words of ＂carotid atherosclerosis,＂＂carotid intima-media thickness,＂＂carotid plaque,＂＂carotid stenosis,＂＂nonstroke,＂ and ＂cognitive impairment.＂Study Selection： Articles were obtained and reviewed to analyze the role of carotid atherosclerosis such as carotid intima-thickness, carotid plaque, and carotid stenosis in the progress of cognitive impairment in nonstroke patients and the possible mechanisms. Results： In recent years, most studies proved that by evaluating carotid atherosclerosis with ultrasonography, carotid atherosclerosis accounts for the development of cognitive decline in nonstroke patients. carotid atherosclerosis not only impairs the subtle general cognitive function but also decreases the specific domains of cognitive function, such as memory, motor function, visual perception, attention, and executive function. But, it is still controversial. The possible mechanisms of cognitive impairment in nonstroke patients with carotid atherosclerosis can be classified as systemic global cerebrovascular function, small-vessel diseases, and the mixed lesions. Conclusions： carotid atherosclerosis can be used to predict the risk of cognitive impairment. Furthermore, diagnosing and treating carotid atherosclerosis at early stage might help clinicians prevent and treat vascular cognitive impairment in nonstroke patients.

关键词： carotid atherosclerosis carotid Intima-media Thickness: carotid Plaque carotid Stenosis Cognitive Impairment Nonstroke

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Association between Metabolic Syndrome and carotid atherosclerosis: A Cross-sectional Study in Northern China

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Biomedical and Environmental Sciences 2019年第12期32卷 914-921页

作者： ZHOU Ping An ZHANG Chen Huan CHEN Yan Ru LI Dong SONG Dai Yu LIU Hua Min ZHOU Ming Yue SONG Guo Shun CHEN Sheng Yun Department of Ultrasound Yan'an University Affiliated HospitalYan'an 716000ShanxiChina Department of Epidemiology School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric DiseasesMedical College of Soochow UniversitySuzhou 215123JiangsuChina School of public health Shandong First Medical University&Shandong Academy of Medical SciencesTai'an 271016ShandongChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Staff Hospital of Chinese National Petroleum Jidong Oilfield IncTangshan 063200HebeiChina Stroke center Sanbo Brain HospitalCapital Medical UniversityBeijing 100093China

Objective Increased carotid artery intima-media thickness(CIMT)and carotid plaque as manifestations of carotid atherosclerosis have been used as markers of cardiovascular disease(CVD).The components of metabolic syndrome(Met S)are linked to CVD,but the association between Met S and CVD is *** A total of 8,933 Chinese adults aged 40 years or older from 2010 to 2014 were selected from the Jidong and Kailuan *** S was defined by the International Diabetes Federation *** and carotid plaque were measured using color Doppler *** regression models were used to assess the association of Met S with carotid plaque and *** Met S was found among 3,461(3,461/8,933)*** odds ratio and 95%confidence internal(CI)for carotid plaques in participants with Met S was 1.16(1.03-1.30).The risk of carotid plaques increased with the number of Met S *** average CIMT was higher in participants with Met S(β=0.020,95%CI,0.014-0.027)and in participants with more Met S *** Individuals with Met S are at an increased risk for carotid atherosclerosis compared to those without MetS.

关键词： Metabolic syndrome Components carotid atherosclerosis Intima-media thickness

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Research Progress of Traditional Chinese Medicine in the Treatment of carotid atherosclerosis

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Journal of Clinical and Nursing Research 2022年第1期6卷 76-79页

作者： Xinya Zhao Yongjun Fang The First Clinical Medical College Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina The Affiliated Hospital of Shaanxi University of Chinese Medicine Xianyang 712000Shaanxi ProvinceChina

carotid atherosclerosis is a partial manifestation of arteriosclerosis of *** recent years,its incidence rate is increasing year by *** Chinese medicine(TCM)has a broad prospect in the clinical development of CAS treatment by holism concept and the principle of treatment based on syndrome *** paper reviews the etiology,pathogenesis,TCM dialectics and TCM treatment of carotid atherosclerosis,in order to provide theoretical guidance for TCM treatment of CAS patients.

关键词： carotid atherosclerosis CAS Traditional Chinese medicine Single Chinese herb

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Effects of apolipoprotein A polymorphism on plasma levels of lipids, progression of carotid atherosclerosis and response to statin therapy

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South China Journal of Cardiology 2015年第4期16卷 239-243,251页

作者：卢剑华胡允兆谭建锋林涛郭文飞李军 VIP Ward Shunde First People's Hospital Affiliated to Southern Medical University Guangdong Sanjiu Brain Hospital

Background Studies have shown that the apt （a） gene （LPA） rs3798220 polymorphism is associated with thelevels of lipids and the curative effect of statin therapy for carotid atherosclerosis （CAS）. Whether carriers ofan apt （a） variant benefit more from statin remains unclear. Methods One hundred and three patients with CAS were recruited from April 2012 to April 2013 in the Shunde First People＇s Hospital Affiliated to Southern Medical University in Foshan. All patients were administered atorvastatin 20 mg/d and were followed-up for 2 years, with the levels of plasma Lp （a）, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL）, low density lipoprotein （LDL）. LPA rs3798220 genotypes of all patients were analyzed. Results Statin treatment significantly reduced the levels of IMT, TC, TG, LDL and increased the level of HDL, but statin treatment did not reduce the level ofLp （a）. According to the curative effect of statin therapy in patients with CAS, rs3798220 polymorphism had a certain influence on LDL and TC levels, but not on the improvement of the IMT, TG, HDL and Lp （a）. Conclusion Rs 3798220 polymorphism has a certain impact on the curative effects of statin, on LDL and TC levels.

关键词： carotid atherosclerosis statin apolipoprotein A gene

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Feature selection and machine learning approach for carotid atherosclerosis in asymptomatic adults

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Medical Data Mining 2022年第4期5卷 35-41页

作者： Tao Liang Qiao-Li Wang Xiao-Qin Liu Zhen Zhou Scott Lowe Zi-Heng Chen Chen-Yu Sun Department of Gastroenterology Peoples’Hospital of Deyang CityDeyang 618000China Department of Physical Examination Center Peoples’Hospital of Deyang CityDeyang 618000China Menzies Institute for Medical Research University of TasmaniaHobartTAS 7000Australia College of Osteopathic Medicine Kansas City UniversityKansas CityMO 64106USA Applied Mathematics and Statistics Stony Brook UniversityStony BrookNY 11794USA AMITA Health Saint Joseph Hospital Chicago University of Illinois ChicagoChicago 60657USA

Objective:The presence of carotid atherosclerosis reflects the overall atherosclerotic load and may predict cardiovascular and cerebrovascular *** have reported risk factors for carotid ***,few practical models have been established to predict carotid atherosclerosis ***,this study was conducted to investigate important features of carotid atherosclerosis and to propose a machine learning-based method for predicting carotid atherosclerosis in asymptomatic ***:Cross-sectional study was conducted using routine medical check-up data of individuals from January 2019 to January ***’s correlation analysis was performed to correlate the ***,features were selected by python’s feature-selection library and analyzed through three *** machine learning algorithms,including Decision Tree,Random Forest and Logistic Regression(LR)were used to predict the risk of carotid atherosclerotic plaques and compared their precision,accuracy,recall,F1-score and area under the ***:A total of 150 individuals were enrolled in this study,30(20%)of them were found with carotid atherosclerotic ***,age,body mass index,total cholesterol,Systolic blood pressure(SBP),and carbohydrate antigen 724(CA724)were independently correlated to carotid *** Ⅰ and pepsinogen Ⅱ serum levels had no correlations with carotid intima-media thickness and pulse wave ***,diastolic blood pressure age,low-density lipoprotein,Pepsinogen I,pepsinogen II,body mass index,Waist,CA724,and Uric Acid contribute to the cumulative importance of 0.9,and SBP was the most crucial feature for carotid *** algorithm has the precision(0.92),values of recall(0.91),F1(0.9),and area under the curve(0.95),and showed the optimal performance to predict the presence or absence of carotid atherosclerosis in asymptomatic *** code for analysis in this article was uploaded to GitHub(https://githu

关键词： machine learning feature selection gastric biomarkers carotid atherosclerosis asymptomatic adults

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Pathological Mechanism of “Phlegm, Blood stasis, Toxin ”in a Rabbit Model of carotid atherosclerosis Based on Gut Microbiota-host Metabolism Interactions

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Clinical Complementary Medicine and Pharmacology 2023年第2期3卷 10-21页

作者： Feng Zhang Yanyun Xu Liye Shen Junjie Huang Songtao Xu Minli Chen Yongming Pan The Second School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina Academy of Chinese Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 311402ZhejiangChina Key Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province Hangzhou 310006ZhejiangChina

Background:In Traditional Chinese Medicine(TCM)theory,"phlegm,blood stasis and toxin"are the pathogenesis of carotid atherosclerosis(CAS).The rabbit carotid atherosclerosis(CAS),which is induced by high-cholesterol diet combined with carotid artery balloon injury,is a classic model for studying *** studies indicate that gut microbiota and host metabolic disorders are involved in the pathogenesis of rabbit ***,the TCM pathological features and syndromes of this classic rabbit CAS model have not been ***:To explore the pathogenesis of the rabbit CAS model and its TCM syndrome types from the perspective of"phlegm,blood stasis,and toxin".Methods:Twelve male New Zealand white rabbits were randomly divided into NC group and CAS group according to their body weight,followed by feeding of basic feed and a 1%high cholesterol diet,*** two weeks,the rabbits in the CAS group underwent common carotid artery(CCA)balloon injury,while the rabbits in the NC group underwent only CCA separation without balloon *** two groups received differential feed postoperatively for six more weeks,after which,changes in lipids,hemorheology,inflammation,oxidative stress,and CAS phenotypes were *** addition,the colon contents and serum were collected for 16S rRNA sequencing and ^(1)H-NMR metabonomic ***:The CAS rabbits were observed to form noticeable abnormalities in lipid metabolism and blood rhe-ology,a sharp increase in oxidative stress levels,excessive release of inflammatory factors and apparent CAS plaque ***,10 specific gut microbiota(such as Akkermansia muciniphila,Barnesiellaceae and Faecalibacterium)and 14 characteristic metabolites(such as trimethylamine oxide,acetic acid and L-carnitine)were identified in the CAS rabbits,which were significantly related to the CAS *** pathway func-tion analysis showed that the gut microbiota and its metabolites mainly affected cholesterol metabolism,ener

关键词： carotid atherosclerosis Phlegm Blood stasis Toxin Gut microbiota Host metabolism Animal model

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Interplay between chronic hepatitis B and atherosclerosis:Innovative perspectives and theories

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World Journal of Gastroenterology 2022年第4期28卷 497-499页

作者： Ivan Ranković Vladimir Milivojević Aleksandra PavlovićMarković Mihailo Bezmarević Clinic for Gastroenterology and Hepatology University Clinical Center of SerbiaBelgrade 11000Serbia Clinic for Gastroenterology and Hepatology University Clinical Center of SerbiaSchool of MedicineUniversity of BelgradeBelgrade 11000Serbia Department of Hepatobiliary and Pancreatic Surgery Clinic for General SurgeryMilitary Medical AcademyUniversity of DefenseBelgrade 11000Serbia

Elaboration of carotid atherosclerosis in the setting of hepatitis B virus(HBV)infection should emphasize the significance of extrahepatic manifestations of the infection *** processes comprise the pathoevolution of HBV infection,rendering it a multi-systemic disease in its *** work not only exemplified atherosclerosis as an often-underestimated contributor to the severity of HBV infection but has also highlighted the bidirectional relationship between the ***,it is suggested that HBV-induced inflammation is one of the root causes of atherosclerosis,which in turn has a consequent effect on the severity of the chronic infection disease state,creating a vicious ***,we coupled prior data with the current concepts of HBV infection to postulate intriguing perspectives and theories.

关键词： Hepatitis B virus infection carotid atherosclerosis Hepatitis B e antigen Arterial inflammation Perspectives and trends

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Oral fibrinogen-depleting agent lumbrokinase for secondary ischemic stroke prevention： results from a multicenter, randomized, parallel- group and controlled clinical trial

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Chinese Medical Journal 2013年第21期126卷 4060-4065页

作者： Cao Yong-jun Zhang Xia Wang Wan-hua Zhai Wan-qing Qian Ju-fen Wang Jian-sheng Chen Jun You Nian-xing Zhao Zhong Wu Qiu-yi Xu Yuan Yuan Lei Li Rui-xia Liu Chun-feng Soochow Univ Affiliated Hosp 2 Dept Neurol Suzhou 215004 Jiangsu Peoples R China Kunshan 1 Peoples Hosp Dept Neurol Kunshan 215300 Jiangsu Peoples R China Taicang 1 Peoples Hosp Dept Neurol Taicang 215400 Jiangsu Peoples R China Zhangjiagang Tradit Chinese Med Hosp Dept Neurol Zhaniagang 215600 Jiangsu Peoples R China Changshu 1 Peoples Hosp Dept Neurol Changshu 215500 Jiangsu Peoples R China Wuxi Tradit Chinese Med Hosp Dept Neurol Wuxi 214000 Jiangsu Peoples R China Changshu 2 Peoples Hosp Dept Neurol Changshu 215500 Jiangsu Peoples R China Suzhou Municipal Hosp Dept Neurol Suzhou 215000 Jiangsu Peoples R China Zhangjiagang 1 Peoples Hosp Dept Neurol Zhangjiagang 215600 Jiangsu Peoples R China Wujiang 1 Peoples Hosp Dept Neurol Wujiang 215200 Jiangsu Peoples R China Taicang Tradit Chinese Med Hosp Dept Neurol Taicang 215400 Jiangsu Peoples R China

Background Elevated fibrinogen （Fg） level is a known risk factor for ischemic stroke. There are few clinical trials on oral fibrinogen-depleting therapies for secondary ischemic stroke prevention. We aimed to assess the effects of one-year therapy with oral lumbrokinase enteric-coated capsules on secondary ischemic stroke prevention.

关键词： ischemic stroke lumbrokinase enteric-coated capsules fibrinogen carotid atherosclerosis

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Neovascularization in the carotid atherosclerotic plaque is not associated with inflammatory cell aggregation

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Chinese Medical Journal 2013年第16期126卷 3073-3078页

作者： GAI Jing-jing LIU Hong-bin LI Juan XIE Lei-xing ZHAO Xi-hai CHENG Liu-quan CHEN Hui-jun WANG Yong YIN Da-yi LIU Jia-jin ZHANG Xiong-wei Department of Cardiology Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Radiology Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Nuclear Chinese People's Liberation Army General Hospital Beijing 100853 China Centre for Biomedical Imaging Research Tsinghua University Beijing 100084 China Vascular Imaging Laboratory University of Washington Seattle WA 98109 USA

Background Monocytes and macrophages in atherosclerotic plaque lead to plaque *** aim of the study was to determine if plaque neovascularization led to *** Patients were consecutively enrolled if their carotid intimal media thickness was ＞2 mm,as revealed by duplex *** patients then underwent dynamic contrast enhanced magnetic resonance imaging （DCE MRI） and fluorine-18 fluorodeoxyglucose （18F-FDG） positron emission tomography combined with computed tomography （PET CT）.A target to background ratio （TBR） of ＞1.25 or ＜1.25 served as the cutoff point for the presence and absence of inflammation,*** Twenty-six patients underwent bilateral carotid DCE MRI and 24 patients also underwent PET *** hundred and fifty-five plaques were evaluated by both DCE MRI and PET *** was no significant difference in plaque morphology between the TBR ＞1.25 （n=61） and TBR ＜1.25 （n=94） *** significant differences were found in plasma volume and transfer constant between the TBR ＞1.25 and TBR ＜1.25 *** Our study did not find a significant correlation between plaque neovascularization and the aggregation of inflammatory cells.

关键词： carotid atherosclerosis dynamic contrast enhanced magnetic resonance imaging positron emission tomography macrophages,neovascularization

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Comparative study on hemodynamic environments around patient-specific carotid atherosclerotic plaques with different symmetrical features

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Medicine in Novel Technology and Devices 2021年第3期11卷 182-188页

作者： Xianghui Gong Zhuqing Liang Yawei Wang Chi Zhang Sheng Xie Yubo Fan Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Centre for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Radiology China-Japan Friendship HospitalBeijingChina

Atherosclerotic plaque near the carotid sinus is a key risk factor for ischemic *** disturbed hemodynamic environments around atherosclerotic plaque had been investigated in many studies,the effect of their symmetrical features,especially longitudinal asymmetrical characteristics,had not been comparatively *** this study,three-dimensional carotid bifurcation models were established based on CT images of three patients with 50%stenosis and with different symmetrical features of carotid atherosclerotic plaques including concentric plaque,eccentric plaque,or eccentric longitudinal asymmetrical plaque.A healthy subject was chosen as the *** shear stress(WSS)and oscillating shear index in the regions of upstream,downstream,downstream shoulders and regions around the point of maximum stenosis were *** results indicated that the maximum WSS around the eccentric longitudinal asymmetrical plaque were 8.6 times larger than that of the eccentric plaque and 1.9 times larger than that of the concentric *** the distributions of WSS and OSI around the eccentric longitudinal asymmetric plaque were more disordered than those of the *** results highlighted the risk of the eccentric longitudinal asymmetrical plaque on plaque development and rupture and might provide a new index for evaluating the development of atherosclerosis.

关键词： carotid atherosclerosis Hemodynamic environments Symmetrical characteristic Eccentricity index

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