Neovascularization in the carotid atherosclerotic plaque is not associated with inflammatory cell aggregation

作     者：GAI Jing-jing LIU Hong-bin LI Juan XIE Lei-xing ZHAO Xi-hai CHENG Liu-quan CHEN Hui-jun WANG Yong YIN Da-yi LIU Jia-jin ZHANG Xiong-wei 

作者机构：Department of Cardiology Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Radiology Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Nuclear Chinese People's Liberation Army General Hospital Beijing 100853 China Centre for Biomedical Imaging Research Tsinghua University Beijing 100084 China Vascular Imaging Laboratory University of Washington Seattle WA 98109 USA 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2013年第126卷第16期

页      面：3073-3078页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：carotid atherosclerosis dynamic contrast enhanced magnetic resonance imaging positron emission tomography macrophages,neovascularization 

摘      要：Background Monocytes and macrophages in atherosclerotic plaque lead to plaque *** aim of the study was to determine if plaque neovascularization led to *** Patients were consecutively enrolled if their carotid intimal media thickness was 2 mm,as revealed by duplex *** patients then underwent dynamic contrast enhanced magnetic resonance imaging （DCE MRI） and fluorine-18 fluorodeoxyglucose （18F-FDG） positron emission tomography combined with computed tomography （PET CT）.A target to background ratio （TBR） of 1.25 or 1.25 served as the cutoff point for the presence and absence of inflammation,*** Twenty-six patients underwent bilateral carotid DCE MRI and 24 patients also underwent PET *** hundred and fifty-five plaques were evaluated by both DCE MRI and PET *** was no significant difference in plaque morphology between the TBR 1.25 （n=61） and TBR 1.25 （n=94） *** significant differences were found in plasma volume and transfer constant between the TBR 1.25 and TBR 1.25 *** Our study did not find a significant correlation between plaque neovascularization and the aggregation of inflammatory cells.