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An extracellular matrix-mimetic coating with dual bionics for cardiovascular stents

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Regenerative Biomaterials 2023年第1期10卷 1149-1160页

作者： Nuoya Chen Mingyu Li Haoshaung Wu Yumei Qin Jian Wang Kai Xu Rifang Luo Li Yang Yunbing Wang Xingdong Zhang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Shanxi Key Laboratory of Functional Proteins Shanxi Jinbo Bio-Pharmaceutical Co.LtdTaiyuan 030032ShanxiChina Department of Cardiology General Hospital of Northern Theater CommandShenyang 110000China

Anti-inflammation and anti-coagulation are the primary requirements for cardiovascular stents and also the widely accepted trajectory for multi-functional *** this work,we proposed an extracellular matrix(ECM)-mimetic coating for cardiovascular stents with the amplified functionalization of recombinant humanized collagen type III(rhCOL III),where the biomimetics were driven by structure mimicry and component/function ***,the structure-mimic was constructed by the formation of a nanofiber(NF)structure via the polymerization of polysiloxane with a further introduction of amine groups as the nanofibrous *** fiber network could function as a three-dimensional reservoir to support the amplified immobilization of rhCoL *** rhCOL III was tailored for anti-coagulant,anti-inflammatory and endothelialization promotion properties,which endows the ECM-mimetic coating with desired surface *** implantation in the abdominal aorta of rabbits was conducted to validate the in vivo re-endothelialization of the ECM-mimetic *** mild inflammatory responses,anti-thrombotic property,promotion of endothelialization and suppression of excessive neointimal hyperplasia confirmed that the ECM-mimetic coating provided a promising approach for the modification of vascular implants.

关键词： cardiovascular stent recombinant humanized collagen type III extracellular matrix anti-coagulation endothelialization

Design, Characterization, and 3D Printing of cardiovascular stents with Zero Poisson’s Ratio in Longitudinal Deformation

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Engineering 2021年第7期7卷 979-990页

作者： Chengjin Wang Lei Zhang Yongcong Fang Wei Sun Biomanufacturing Center Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing Beijing 100084China “Biomanufacturing and Engineering Living Systems”Innovation International Talents Base(111 Base) Beijing 100084China Department of Mechanical Engineering Drexel UniversityPhiladelphiaPA 19104USA

Inherent drawbacks associated with drug-eluting stents have prompted the development of bioresorbable cardiovascular *** manufacturing(3-dimentional(3D)printing)has been widely applied in medical *** this study,we develop a novel screw extrusion-based 3D printing system with a new designed mini-screw extruder to fabricate stents.A stent with a zero Poisson’s ratio(ZPR)structure is designed,and a preliminary monofilament test is conducted to investigate appropriate fabrication parameters.3D-printed stents with different geometric structures are fabricated and analyzed by observation of the surface *** evaluation of the mechanical properties and a preliminary biological evaluation of 3D-printed stents with different parameters are carried *** conclusion,the screw extrusion-based 3D printing system shows potential for customizable stent fabrication.

关键词： Additive manufacturing 3D printing Screw extrusion cardiovascular stent Zero Poisson’s ratio

Advances in coatings on magnesium alloys for cardiovascular stents-A review

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Bioactive Materials 2021年第12期6卷 4729-4757页

作者： Zhao-Qi Zhang Yong-Xin Yang Jing-An Li Rong-Chang Zeng Shao-Kang Guan School of Material Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education) Zhengzhou University100 Science RoadZhengzhou450001PR China Corrosion Laboratory for Light Metals College of Material Science and EngineeringShandong University of Science and TechnologyQingdao266590China

Magnesium(Mg)and its alloys,as potential biodegradable materials,have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and ***,the occurrence of thrombosis,inflammation,and restenosis of implanted Mg alloy stents caused by their poor corrosion resistance and insufficient endothelialization restrains their anticipated clinical *** surface treatment tactics have mainly striven to modify the Mg alloy for inhibiting its degradation rate and enduing it with biological *** review focuses on highlighting and summarizing the latest research progress in functionalized coatings on Mg alloys for cardiovascular stents over the last decade,regarding preparation strategies for metal oxide,metal hydroxide,inorganic nonmetallic,polymer,and their composite coatings;and the performance of these strategies in regulating degradation behavior and *** research direction is also concisely discussed to help guide biological functionalized strategies and inspire further *** is hoped that this review can give assistance to the surface modification of cardiovascular Mg-based stents and promote future advancements in this emerging research field.

关键词： Magnesium alloy cardiovascular stent Surface modification Rapid endothelialization Functional properties

Mg-Zn-Y-Nd coated with citric acid and dopamine by layer-by-layer self-assembly to improve surface biocompatibility

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Science China(Technological Sciences) 2018年第8期61卷 1228-1237页

作者： CHEN Li LI JingAn CHANG JiaWei JIN ShiBo WU Di YAN HaoHao WANG XiaoFeng GUAN ShaoKang School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450001China School of Life Science Zhengzhou UniversityZhengzhou 450001 China National Center for International Research of Micro-nano Molding Technology & Key Laboratory for Micro Molding Technology of Henan Province Zhengzhou 450001 China

Magnesium alloy has been generally accepted as an important biodegradable material on cardiovascular stent development for a long time. However, its limited biocompatibility, especially delayed endothelialization process restricts its further application. In this contribution, we modified the Mg-Zn-Y-Nd alloy surface with citric acid and dopamine via a layer-by-layer self-assembly assay, aiming at improving the biocompatibility of the magnesium alloy. The citric acid/dopamine(CA/PDA) layer exhibited a remarkable suppression of platelet activation/aggregation and thrombosis under 15 dyn/cm2 blood flowing. Inhibition on vascular smooth muscle cells growth and macrophages attachment/activation were also observed on this layer. In particular, the CA/PDA layer presented a promoted property for the vascular endothelial cells growth and spreading compared with the bare magnesium alloy, suggesting the pro-endotelialized function. In conclusion, this research may support potential application on surface modification of magnesium alloy based cardiovascular stents for better biocompatibility.

关键词： cardiovascular stent Mg-Zn-Y-Nd alloy biocompatibility layer-by-layer self-assembly citric acid dopamine

A promoting nitric oxide-releasing coating containing copper ion on ZE21B alloy for potential vascular stent application

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Journal of Magnesium and Alloys 2023年第12期11卷 4542-4561页

作者： Qianying Jia Qinggong Jia Shijie Zhu Yufeng Zheng Yoji Mine Kazuki Takashima Shaokang Guan School of Materials Science and Engineering&Henan Key Laboratory of Advance Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education) Zhengzhou UniversityZhengzhou 450001China Department of Materials Science and Engineering Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan International Research Organization for Advanced Science and Technology(IROAST) Kumamoto University2-39-2 Kumamoto 860-8555Japan School of Materials Science and Engineering Peking UniversityBeijing 100871China

Magnesium-based biodegradable metals as cardiovascular stents have shown a lot of excellent performance, which have been used to treat coronary artery diseases. However, the excessive degradation rate, imperfect biocompatibility and delayed re-endothelialization still lead to a considerable challenge for its application. In this work, to overcome these shortcomings, a compound of catalyzing nitric oxide(NO) generation containing copper ions(Cu^(2+)) and hyaluronic acid(HA), an important component of the extracellular matrix, were covalently immobilized on a hydrofluoric acid(HF)-pretreated ZE21B alloy via amination layer for improving its corrosion resistance and endothelialization. Specifically,the Cu^(2+) chelated firmly with a cyclen 1,4,7,10-tetraazacyclododecane-N’, N’’, N’’’, N-tetraacetic acid(DOTA) could form a stability of hybrid coating, avoiding the explosion of Cu^(2+). The chelated Cu^(2+) enabled the catalytic generation of NO and promoted the adhesion and proliferation of endothelial cells(ECs) in vascular micro-environment. In this case, the synergistic effect of NO-generation and endothelial glycocalyx molecules of HA lead to efficient ECs promotion and smooth muscle cells(SMCs) inhibition. Meanwhile, the blood compatibility also had achieved a marked improvement. Moreover, the standard electrochemical measurements indicated that the functionalized ZE21B alloy had better anti-corrosion ability. In a conclusion, the dual-functional coating displays a great potential in the field of biodegradable magnesium-based implantable cardiovascular stents.

关键词： ZE21B alloy Functional coating Hyaluronic acid Nitric oxide cardiovascular stent

In vitro corrosion properties of HTHEed Mg-Zn-Y-Nd alloy microtubes for stent applications:Influence of second phase particles and crystal orientation

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Journal of Magnesium and Alloys 2022年第5期10卷 1286-1295页

作者： Peihua Du Di Mei Tsuyoshi Furushima Shijie Zhu Liguo Wang Yifan Zhou Shaokang Guan School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Henan Key Laboratory of Advanced magnesium Alloys Zhengzhou 450002China Key Laboratory of Advanced Materials Processing and Mold Ministry of Education Zhengzhou 450002China Department of Mechanical and Biofunctional Systems Institute of Industrial ScienceThe University of Tokyo4-6-1KomabaMeguroTokyo 153-8505Japan Magnesium Innovation Centre-MagIC Institute of Materials ResearchHelmholtz-Zentrum GeesthachtGeesthacht 21502Germany

Magnesium(Mg)alloys are promising materials for cardiovascular stent applications due to their good biocompatibility and ***,in vitro and in vivo corrosion tests reveal that Mg alloy stents suffer from a rapid corrosion rate and severe localized corrosion,which is limiting their widespread *** solve the problem of uneven degradation of stents,a HTHE(long-time and high-temperature heat treatment,large-reduction-ratio hot extrusion)process is used to manufacture Mg-Zn-Y-Nd alloy microtubes in this *** heat treatment is to dissolve alloying elements and reduce the size of SPPs,and the hot extrusion is to acquire fine-grained and strongly textured *** microstructural characterization shows that coarse second phases in as-cast alloy are refined and uniformly distributed in matrix of *** hot extrusion,microtubes show strong texture with basal plain oriented parallel to the longitudinal section(LS).The corrosion testing indicates that severe localized corrosion occurs on the cross section(CS)while localized corrosion is alleviated on the *** on the different corrosion properties of the LS and CS,HTHEed microtubes are promising for solving the problems of rapid corrosion rate and severe localized corrosion of Mg alloy stents.

关键词： Mg-Zn-Y-Nd alloy Microtubes Heat treatment Hot extrusion Corrosion properties cardiovascular stent

Development of a polycaprolactone/poly(p-dioxanone)bioresorbable stent with mechanically self-reinforced structure for congenital heart disease treatment

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Bioactive Materials 2021年第9期6卷 2969-2982页

作者： Fan Zhao Jing Sun Wen Xue Fujun Wang Martin W.King Chenglong Yu Yongjie Jiao Kun Sun Lu Wang College of Textiles Donghua UniversityShanghai201620China Key Laboratory of Textile Science and Technology Ministry of EducationCollege of TextilesDonghua UniversitySongjiang DistrictShanghai201620China Department of Pediatric Cardiology Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityNo.1665 Kongjiang RoadShanghai200092China Wilson College of Textiles North Carolina State UniversityRaleigh27606USA

Recent progress in bioresorbable stents(BRSs)has provided a promising alternative for treating coronary artery ***,there is still lack of BRSs with satisfied compression and degradation performance for pediatric patients with congenital heart disease,leading to suboptimal therapy ***,we developed a mechanically self-reinforced composite bioresorbable stent(cBRS)for congenital heart disease *** cBRS consisted of poly(p-dioxanone)monofilaments and polycaprolactone/poly(p-dioxanone)core-shell composite *** points in cBRS structure were partially bonded,offering the cBRS with significantly higher compression force compared to typical braids and remained good *** suitable degradation profile of the cBRS can possibly preserve vascular remodeling and healing *** addition,the controllable structural organization provides a method to customize the performance of the cBRS by altering the proportion of different components in the *** in vivo results suggested the cBRS supported the vessel wall similar to that of metallic *** both abdominal aorta and iliac artery of porcine,cBRS was entirely endothelialized within 1 month and maintained target vessels with good patency in the 12-month *** in vivo degradation profile of the cBRS is consistent with static degradation results in *** is also demonstrated that there is minimal impact of pulsatile pressure of blood flow and variation of radial force on the degradation rate of the ***,the lumen of cBRS implanted vessels were enlarged after 6 months,and significantly larger than the vessels implanted with metallic stent in 12 months.

关键词： cardiovascular stent Bioresorbable Congenital heart disease Braided technology Thermal treatment