An extracellular matrix-mimetic coating with dual bionics for cardiovascular stents

作     者：Nuoya Chen Mingyu Li Haoshaung Wu Yumei Qin Jian Wang Kai Xu Rifang Luo Li Yang Yunbing Wang Xingdong Zhang 

作者机构：National Engineering Research Center for BiomaterialsSichuan UniversityChengdu 610064China Shanxi Key Laboratory of Functional ProteinsShanxi Jinbo Bio-Pharmaceutical Co.LtdTaiyuan 030032ShanxiChina Department of CardiologyGeneral Hospital of Northern Theater CommandShenyang 110000China 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2023年第10卷第1期

页      面：1149-1160页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by the National Natural Science Foundation of China(32101107) CAMS Innovation Fund for Medical Sciences(2021-I2M-5-013) 

主　　题：cardiovascular stent recombinant humanized collagen type III extracellular matrix anti-coagulation endothelialization 

摘      要：Anti-inflammation and anti-coagulation are the primary requirements for cardiovascular stents and also the widely accepted trajectory for multi-functional *** this work,we proposed an extracellular matrix(ECM)-mimetic coating for cardiovascular stents with the amplified functionalization of recombinant humanized collagen type III(rhCOL III),where the biomimetics were driven by structure mimicry and component/function ***,the structure-mimic was constructed by the formation of a nanofiber(NF)structure via the polymerization of polysiloxane with a further introduction of amine groups as the nanofibrous *** fiber network could function as a three-dimensional reservoir to support the amplified immobilization of rhCoL *** rhCOL III was tailored for anti-coagulant,anti-inflammatory and endothelialization promotion properties,which endows the ECM-mimetic coating with desired surface *** implantation in the abdominal aorta of rabbits was conducted to validate the in vivo re-endothelialization of the ECM-mimetic *** mild inflammatory responses,anti-thrombotic property,promotion of endothelialization and suppression of excessive neointimal hyperplasia confirmed that the ECM-mimetic coating provided a promising approach for the modification of vascular implants.