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Synthesis, Spectroscopic Characterization and Thermogravimetric Analysis of Cr(Ⅱ), Cu(Ⅱ), Zn(Ⅱ) and Mg(Ⅱ),captopril Coordination Compounds

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光谱学与光谱分析 2020年第2期40卷 661-664页

作者： Asma SAl-Wasidi Nawal MAl-Jafshar Amal MAl-Anazi Ahmed M.Naglah Robson Fde Farias Claudio Airoldi Moamen SRefat Department of Chemistry College of SciencePrincess Nourah Bint Abdulrahman UniversityRiyadh 11671Saudi Arabia Department of Pharmaceutical Chemistry Drug Exploration and Development Chair(DEDC)College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia Peptide Chemistry Department Chemical Industries Research DivisionNational Research CentreCairo 12622-DokkiEgypt Departamento de Química Universidade Federal do Rio Grande do NorteCx.Postal 166459078-970 NatalRio Grande do NorteBrasil Instituto de Química Universidade Estadual de CampinasBrasil Chemistry Department Faculty of ScienceTaif UniversityP.O.Box 888Al-HawiahTaif 21974Saudi Arabia Department of Chemistry Faculty of SciencePort SaidPort Said UniversityEgypt

In this work,we have reported the synthesis and spectroscopic characterization of captopril(Cap)coordination compounds:Cu(Cap)·2H 2O,Cr(Cap)·H 2O,Zn(Cap)·3H 2O and Mg(Cap)***,it is worthily mentioned that the FTIR spectroscopic technique was employed to recognized the nature of coordination between captopril ligand and copper,chromium,zinc and magnesium(Ⅱ)metal *** view of the infrared spectroscopic tool,the copper(Ⅱ)metal ion coordinated toward captopril drug ligand through sulfur atom of SH group dependent on the absent of stretching vibration band of—*** on this result,the stretching motion ofνa(COO)shifts clearly indicates that Cu 2+,Cr 2+,Zn 2+and Mg 2+the carboxylic group is employed as coordinative site for all compounds as a metal-ligand coordinative *** a general behavior,it is verified that the coordination compound thermal stability(considering the release of captopril molecules,not the release of water molecules)is affected by the metal cation radius:minor radius is associated with higher thermal stability,probably due to a higher metal-captopril bond dissociation enthalpy.

关键词： captopril Transition metals Spectroscopy Coordination compounds Thermogravimetry

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Spectrofluorimetric analysis of captopril based on its obstruction effect of the nanomaterial surface energy transfer between acridine orange and gold nanoparticles

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Science China Chemistry 2015年第5期58卷 885-891页

作者： Jingfang Guo Yamei Yang Xiaoli Hu Yuanfang Li Key Laboratory of Luminescent and Real-Time Analytical Chemistry Ministry of Education College of Chemistry and Chemical Engineering Southwest University

A simple and sensitive method for detection of captopril was established based on its obstructive effect on nanomaterial sur- face energy transfer （NSET）. It was found that the acridine orange （AO） could be adsorbed onto the surface of citrated-gold nanoparticles （AuNPs） through electrostatic interaction. Incidentally, the fluorescence of AO was quenched owing to the dipole-dipole interaction of NSET between AO fluorophore and the AuNPs. However, captopril could obstruct the occurrence of NSET between AO and AuNPs effectively with the formation of Au-S covalent bonds between it and the AuNPs. Consequently, AO molecules were moved away from the surface of AuNPs leading to a decline of the energy transfer efficiency. Moreover, the fluorescence of AO could be gradually restored with the addition of captopril. Under the optimal conditions, the recovered fluorescence intensity correlated linearly with the concentration of captopril in the range of 400 nmol/L-2.0μmol/L with a detection limit of 71 μmol/L. Besides, the proposed method was successfully applied for the detection of captopril in troches with the recovery of 93%-102% and the RSD lower than 2.24%. The results were in good agreement with those obtained from the HPLC method,

关键词： nanomaterial surface energy transfer gold nanoparticles acridine orange captopril

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Compensatory function of bradykinin B1 receptor in the inhibitory effect of captopril on cardiomyocyte hypertrophy and cardiac fibroblast proliferation in neonatal rats

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Chinese Medical Journal 2008年第13期121卷 1220-1225页

作者： ZOU Jun REN Jiang-hua FENG Dan WANG Hong XU Jiang Department of Cardiology Zhongnan Hospital of Wuhan University Wuhan Hubei 430071 China Department of Physiology Medical College of Wuhan University Wuhan Hubei 430071 China

Background Bradykinin （BK） acts mainly on two receptor subtypes： B1 and B2, and activation of B2 receptor mediates the most well-known cardioprotective effects of angiotensin converting enzyme inhibitors （ACEi）, however, the role that B1 receptor plays in ACEi has not been fully defined. We examined the role of B1 receptor in the inhibitory effect of ACE inhibitor captopril on rat cardiomyocyte hypertrophy and cardiac fibroblast proliferation induced by angiotensin Ⅱ （Ang Ⅱ） and explored its possible mechanism. Methods Neonatal cardiomyocytes and cardiac fibroblasts （CFs） were randomly treated with Ang Ⅱ, captopdl, B2 receptor antagonist （HOE-140） and B1 receptor antagonist （des-Arg^10, Leu^9-kallidin） alone or in combination. Flow cytometry was used to evaluate cell cycle, size and protein content. Nitric oxide （NO） and intracellular cyclic guanosine monophosphate （cGMP） level were measured by colorimetry and radioimmunoassay. Results After the CFs and cardiomyocytes were incubated with 0.1 μmol/L Ang Ⅱ for 48 hours, the percentage of CFs in the S stage, cardiomyocytes size and protein content significantly increased （both P 〈0.01 vs control）, and these increases were inhibited by 10 μmol/L captopril. However, NO and cGMP levels were significantly higher than that with Ang Ⅱ alone （both P 〈0.01）. 1 μmol/L HOE-140 or 0.1 pmol/L des-Arg^10, Leu^9-kallidin attenuated the effects of captopril, which was blunted further by blockade of both B1 and B2 receptors. Conclusions Acting via B2 receptor, BK contributes to the antihypertrophic and antiproliferative effects of captopril on cardiomyocytes and CFs. In the absence of B2 receptor, B1 receptor may act a compensatory mechanism for the B2 receptor and contribute to the inhibition of cardiomyocyte hypertrophy and CFs proliferation by captopril. NO and cGMP play an important role in the effect of B1 receptor.

关键词： bradykinin captopril cardiac fibroblast cardiomyocyte

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Preparation and Characterization in vitro of Sustained-release captopril/ Chitosan-gelatin Net-polymer Microspheres(Cap/CGNPMs)

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Journal of Wuhan University of Technology(Materials Science) 2006年第3期21卷 35-40页

作者：宋益民 Chemical School Qingdao University of Science and Technology Qingdao 266042 ChinaDepartment of Biology Ocean University of China Qingdao 266003 China

The captopril/ Chitosan-gelatin net-polymer microspheres （ Gap/ CGNPMs ） were prepared using Chitosan （ CS ） and gelatin （ Gel ） by the methods of emulsification. A cross linked reagent alone or in combination with microcrystalline cellulose （ MCC ） was added in the process of preparation of microspheres to eliminate dose dumping and burst phenomenon of microspheres for the improvemeat of the therapeutic efficiency and the decrease of the side effects of captopril （ Cap ）. The results indicate that Cap/ CGNPMs have a spherical shape , smooth surface roorphology and integral inside structure and no adhesive phenomena and good roobility , and the size distribution is mairdy from 220 to 280 μm. Researches on the Cap release test in vitro demonstrate that Cap/ CGNPMs are of the role of retarding release of Cap compared with Cap ordinary tablets （COT）, embedding ratio （ER） , drug loading （ DL ）, and swelling ratio （ SR ）, and release behaviors of CGNPMS are influenced by process conditions of preparation such as experimental material ratio （EMR） , composition of cross linking reagents. Among these factors , the EMR（1/4）, CLR （ FOR ＋ TPP） and 0.75% microcrystulline cellulose （MCC） added to the microspheres are the optimal scheme to the preparation of Cap/CGNPMs. The Cap/CGNPMs have a good characteristic of sustained release of drug, and the process of emulsifieation and crossinking process is simple and stable. The CGNPMs is probable to be one of an ideal sustained release system for water-soluble drugs.

关键词： captopril chitosan gelatin microsphere drug sustained release

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A chemiluminescence reagent free method for the determination of captopril in medicine and urine samples by using trivalent silver

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Journal of Pharmaceutical Analysis 2017年第4期7卷 252-257页

作者： Zhaofu Fu Wanting Huang Gongke Li Yufei Hu School of Chemistry Sun Yat-sen UniversityGuangzhou 510275China

A novel flow-injection chemiluminescence(FI-CL) method free of CL reagent was developed for the determination of captopril based on its enhancing effect on the CL derived from diperiodatoargentate(Ⅲ)-sulfuric acid system. Compared with the conventional CL system, the CL system based on trivalent silver was characterized of good selectivity for the absence of CL reagent. The CL mechanism was discussed through CL spectra and UV–vis absorption spectra. The conditions of the FI-CL system were investigated and *** the optimal conditions, the relative CL intensity was linear with the captopril concentration in the range of 0.3–15.0 μg/m L. The detection limit for captopril was 0.05 μg/m L, and the relative standard deviation(n=11) was 2.0% for 5.0 μg/m L captopril. The proposed method was applied to the analysis of captopril in tablet and human urine with the recoveries of 83.1%–112.5%, and the relative standard deviations of 0.5%–4.4%. The results obtained by the proposed method agreed well with those obtained from HPLC method. The proposed method is fast, convenient, and cost-effective for the determination of captopril in medicine and biological samples.

关键词： Diperiodatoargentate(Ⅲ) Chemiluminescence Flow injection captopril

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Treatment effects of captopril on non-proliferative diabetic retinopathy

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Chinese Medical Journal 2012年第2期125卷 287-292页

作者： Wang Ning Zheng Zhi Jin Hui-yi Xu Xun Shanghai Jiao Tong Univ Peoples Hosp 1 Dept Ophthalmol Shanghai 200080 Peoples R China

Background Diabetic retinopathy （DR） is one of the most common complications of ***-converting enzyme inhibitor is thought to play an important role in preventing and treating retinal diseases in animal models of *** aim of the present study was to investigate the role of angiotensin-converting enzyme inhibitor （ACEI,captopril） in the treatment of patients with non-proliferative *** Three hundred and seventeen type 2 diabetic patients （88.05% of participants） without or with mild to moderate non-proliferative retinopathy were randomly divided into captopril group （n=202） and placebo group （n=115）.All subjects received 24-month *** clinical examinations,including blood pressure and glycated hemoglobin,as well as comprehensive standardized ophthalmic examinations were *** fundus photography and optical coherence tomography （OCT） were used to grade diabetic retinopathy and detect macular edema *** The levels of blood pressure and glycated hemoglobin in the two groups of patients remained within the normal range during the entire follow-up and no significant difference was found between the initial and last visits,suggesting that ACEI drugs play a protective role on the DR patients independent of its anti-blood pressure *** classification showed that 169 eyes （83.66%） remained unchanged and the DR grade of 33 eyes （16.34%） increased in captopril group,while 84 eyes （73.04%） remained unchanged and the grade of 31 eyes （26.96%） increased in placebo group （P=0.024）.captopril treatment improved macular edema in 55.45% eyes,which was significantly higher than the 37.39% improvement in placebo group （P=0.002）.No significant difference was found in the visual acuity between the two groups （P=0.271）.Conclusion captopril can improve or delay the development of DR and macular edema,which can be used in the early treatment of DR patients with type 2 diabetic mellitus.

关键词： captopril non-proliferative diabetic retinopathy angiotensin-converting enzyme inhibitor

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Determination of captopril in pharmaceutical preparation and biological fluids using two- and three-way chemometrics methods

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Chinese Chemical Letters 2007年第4期18卷 427-430页

作者： Nahid Ghasemi Ali Niazi Department of Chemistry Faculty of SciencesAzad University of ArakArakIran

Spectrophotometric method has been developed for the direct quantitative determination of captopril in pharmaceutical preparation and biological fluids （human plasma and urine） samples. The method was accomplished based on parallel factor analysis （PARAFAC） and partial least squares （PLS）. The study was carried out in the pH range from 2.0 to 12.8 and with a concentration from 0.70 to 61.50μg mL^-1 of captopril. Multivariate calibration models such as PLS at various pH and PARAFAC were elaborated from ultraviolet spectra deconvolution and captopril determination. The best models for this system were obtained with PARAFAC and PLS at pH 2.0. The applications of the method for determination of real samples were evaluated by analysis of captopril in pharmaceutical preparations and biological fluids with satisfactory results. The accuracy of the method, evaluated through the RMSEE was 0.5801 for captopril with best calibration curve by PARAFAC and 0.6168 for captopril with PLS at pH 2.0 model.

关键词： captopril Spectrophotometric Parallel factor analysis Partial least squares Pharmaceutical analysis

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Application of potassium ferricyanide in the spectrophotometric determination of captopril

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Chinese Chemical Letters 2009年第1期20卷 88-91页

作者： Shi Lei Wang Min Wang Quan Min Li College of Chemistry and Environmental Science Henan Normal University Xinxiang 453007 China Department of Chemistry Jiaozuo Teachers College Jiaozuo 454000 China

A novel method for the determination of captopril by spectrophotometer is described in this paper. The experiment is based on the fact that Fe（Ⅲ） is reduced to Fe（Ⅱ） by captopril, then the in sire formed Fe（Ⅱ） reacts with potassium ferricyanide to give the soluble prussian blue at pH 4.00, and its maximal adsorption wavelength （λmax） is 735 nm. Good linear relationship is obtained between the absorbance and the concentration of captopril in the wide range of 0.05-20 μg/mL. The linear regression equation is A = -0.04314 ＋ 0.11423C （μg/mL） with a correlation coefficient R = 0.9998. The detection limit （3σ/k） is 0.04 μg/mL, the molar absorption coefficient is 2.5×10^4 L/mol cm. By mensurating the absorbance of soluble prussian blue, the indirect determination of captopril can be obtained. This method has been successfully applied to determination of captopril in pharmaceutical samples. Analytical results obtained are satisfactory.

关键词： Potassium ferricyanide captopril Prussian blue Spectrophotometry

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Effect of captopril on serum TNF-α level in acute lung injury rats induced by HCL

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Asian Pacific Journal of Tropical Medicine 2014年第11期7卷 905-908页

作者： Hong-Mei Liu Yu-Na Guo Tangshang Clinical College of Hebei Medical University Pain Clinics Xuanwu Hospital Capital Medical University

Objective:To observe the effect of captopril on the tumor necrosis factor-α(TNF- α) level and arterial blood gases in acute lung injury(All) induced by HCL in rats,and to analyze its protective ***:Fifty Wistar rats were selected and randomly divided into three groups,with 20 rats in Group Ⅰ and Ⅱ,respectively and 10 animals in Group Ⅲ.ALI model was constructed by intratracheal injection of diluted hydrochloric acid(pH=1.***.1.2 mL/kg).Group Ⅰrats received not any treatment after construction of AM *** Ⅱ rats were treated with captopril(5 mg/kg,i.p.) 5 min after induction of *** Ⅲ served as normal control without any *** minutes after construction of ALI model,all the rats were *** was withdrawn for detection of TNF- α level and arterial blood gases *** lung tissue slices of the three groups were prepared for observation of pathologic histology ***:TNF- α level in serum of Group Ⅰ and Ⅱ rats was significantly higher than that in Group Ⅲ(Pcaptopril can significantly r

关键词： captopril Acute lung injury TNF-α Lung function

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Efficacy of intravitreal captopril on oxygen-induced retinopathy in mice

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International Journal of Ophthalmology(English edition) 2011年第4期4卷 361-364页

作者： Yu Di, Xiao-Long Chen Department of Ophthalmology Shengjing Hospital of China Medical University Shenyang 110004 Liaoning Province China Graduate School of China Medical University Shenyang 110001 Liaoning Province China

AIM: To study the inhibitory effect of intravitreal captopril on oxygen-induced retinopathy (OIR) in mice. METHODS: Eighty postnatal day (P)7 C57BL/63 mice were randomly divided into treated group and control group with forty mice in each group. The mice were exposed to 75% 2% oxygen for 5 days (P7-P11) and then returned to room air for 5 days (P12-P17) to induce retinal neovascularization (RNV). Beginning on P12, the mice in treated group received daily intravitreal injections of captopril(3.0mL/kg), while those in control group received daily intravitreal injections of phosphate-buffered saline (PBS) (3.0mL/kg) through P17. After anesthetized at P17, one eye was chosen randomly as experimental eye and were enucleated. RNV was examined by Adenosine diphosphate-ase (ADPase) stained retina flat-mounts and was quantitated histologically by counting the neovascular endothelial cell nuclei anterior to inner limiting membrane (ILM). The expressions of matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) were measured by immunohistochemical method. RESULTS: Comparing with control group, more regular distributions, better branch and reduced density of RNV were observed in eyes of treated group. The number of neovascular cell nuclei was less in treated group than that in control group ( t =6.135, P captopril can significantly inhibit RNV in OIR mice.

关键词： retinal neovascularization oxygen-induced retinopathy captopril intravitreal injection

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