A chemiluminescence reagent free method for the determination of captopril in medicine and urine samples by using trivalent silver

作     者：Zhaofu Fu Wanting Huang Gongke Li Yufei Hu 

作者机构：School of ChemistrySun Yat-sen UniversityGuangzhou 510275China 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2017年第7卷第4期

页      面：252-257页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 0817[工学-化学工程与技术] 0703[理学-化学] 0702[理学-物理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (Nos. 21475153, 21575167, 21675178 and 21605163) the Guangdong Provincial Natural Science Foundation (Nos. 2015A030311020 and 2016A030313358) the Special Funds for Public Welfare Research and Capacity Building in Guangdong Province (No.2015A030401036) the Guangzhou Science and Technology Program (No. 201604020165) 

主　　题：Diperiodatoargentate(Ⅲ) Chemiluminescence Flow injection Captopril 

摘      要：A novel flow-injection chemiluminescence(FI-CL) method free of CL reagent was developed for the determination of captopril based on its enhancing effect on the CL derived from diperiodatoargentate(Ⅲ)-sulfuric acid system. Compared with the conventional CL system, the CL system based on trivalent silver was characterized of good selectivity for the absence of CL reagent. The CL mechanism was discussed through CL spectra and UV–vis absorption spectra. The conditions of the FI-CL system were investigated and *** the optimal conditions, the relative CL intensity was linear with the captopril concentration in the range of 0.3–15.0 μg/m L. The detection limit for captopril was 0.05 μg/m L, and the relative standard deviation(n=11) was 2.0% for 5.0 μg/m L captopril. The proposed method was applied to the analysis of captopril in tablet and human urine with the recoveries of 83.1%–112.5%, and the relative standard deviations of 0.5%–4.4%. The results obtained by the proposed method agreed well with those obtained from HPLC method. The proposed method is fast, convenient, and cost-effective for the determination of captopril in medicine and biological samples.