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Diabetes-inducing effects of bronchial asthma

World Journal of Diabetes 2025年第1期16卷 121-139页

作者： Mohammed Al-Beltagi Adel Salah Bediwy Nermin Kamal Saeed Hosameldin A Bediwy Reem Elbeltagi Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain Department of Pulmonology Faculty of MedicineTanta UniversityTanta 31527AlghrabiaEgypt Department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 26671ManamaBahrain Medical Microbiology Section Department of PathologyIrish Royal College of SurgeonBusaiteen 15503MuharraqBahrain Faculty of Medicine Tanta UniversityTanta 31527AlgharbiaEgypt Department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain

BACKGROUND The relationship between diabetes mellitus(DM)and asthma is complex and can impact disease *** To explore the bidirectional influences between the two conditions on clinical outcomes and disease *** We systematically reviewed the literature on the relationship between DM and asthma,focusing on their impacts,mechanisms,and therapeutic *** studies were assessed,which investigated the effect of glycemic control on asthma outcomes,lung function,and *** study highlighted the role of specific diabetes medications in managing *** The results showed that poor glycemic control in diabetes can exacerbate asthma,increase hospitalizations,and reduce lung ***,severe asthma,especially in obese individuals,can complicate diabetes management and make glycemic control more *** diabetes-associated mechanisms,such as inflammation,microangiopathy,and oxidative stress,can exacerbate asthma and decrease lung *** diabetes medications exhibit anti-inflammatory effects that show promise in mitigating asthma *** The complex interrelationship between diabetes and asthma suggests bidirectional influences that affect disease course and *** and microvascular complications associated with diabetes may worsen asthma outcomes,while asthma severity,especially in obese individuals,complicates diabetes ***,the current research has limitations,and more diverse longitudinal studies are required to establish causal relationships and identify effective treatment strategies for individuals with both conditions.

关键词： Diabetes mellitus bronchial asthma Glycemic control Lung function asthma exacerbation Disease interaction Microangiopathy

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Inhaling β_2-agonist with heliox-driven in bronchial asthma

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Chinese Medical Journal 2003年第7期116卷 1011-1015页

作者：解立新刘又宁陈良安郝凤英金桂清赵会泽 Department of Respiratory Medicine General Hospital of PLA Beijing China Department

Objective To evaluate the effectiveness of a helium oxygen mixture (79%He 21%O 2) as an aerosolizing compressed gas for β 2 agonist therapy in patients with an asthma exacerbation Methods Twenty four patients in the outpatient department with a mild to moderate exacerbation of asthma were enrolled The patients were randomly divided into an experimental group (13 cases) and a control group (11 cases) The experimental group inhaled Berotec with heliox driven, and the control group inhaled Berotec with compressed air driven Eight hospitalized patients in the respiratory department with severe exacerbation of asthma were enrolled The patients inhaled Berotec with heliox driven or compressed air driven in a random order Results The results of spirometric parameters and arterial blood gas analysis were measured In the mild to moderate asthma patients, no statistical differences between the two groups for forced vital capacity (FVC), forced expired volume in one second (FEV 1), and expiratory flow in 50% forced vital capacity (FEF 50 ) were presented But the severe patients showed significant differences between heliox driven and compressed air driven for FVC, FEV 1, FEF 50 and partial pressure of oxygen (PaO 2) Conclusions Compared with the traditional inhalation of β 2 agonist therapy using compressed air driven, the method of inhaling β 2 agonist with heliox driven has more obvious benefits for those suffering from severe asthma This is likely due to the cooperative effects between inhaling heliox on its physical gas properties and improving delivery of β 2 agonist in the treatment of exacerbation of severe asthma

关键词： heliox · β 2 agonist · aerosolized inhaling · bronchial asthma

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The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis:Therapeutic implications

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Genes & Diseases 2023年第4期10卷 1537-1551页

作者： Dan Huang Gege Liu Zhiyi Xu Shushu Chen Cuili Wang Dewei Liu Jiahao Cao Junfen Cheng Bin Wu Dong Wu Department of Respiratory and Critical Care Medicine Affiliated Hospital of Guangdong Medical UniversityZhanjiangGuangdong 524000China State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyAvenida Wai LongTaipaMacao SAR 999078China Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Guangdong Medical UniversityZhanjiangGuangdong 524000China

Placental growth factor(PlGF)is a glycosylated dimeric protein that is homologous to vascular endothelial growth factor(VEGF).PlGF expression is upregulated in patients with bronchial asthma,suggesting that it plays a role in the pathogenesis of *** asthma is characterized by chronic airway inflammation and airway hyperresponsiveness(AHR).After recurrent asthma attacks,pulmonary fibrosis develops and leads to airway remo-deling and a further decline in lung *** this review,we focused on the pivotal role of PlGF in chronic airway inflammation,AHR,and airway remodeling during bronchial ***,we summarized data showing that PlGF may be a potential therapeutic target in bronchial asthma.

关键词： AHR Airway remodeling bronchial asthma Chronic airway inflammation PlGF

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Remission of bronchial asthma after viral clearance in chronic hepatitis C

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World Journal of Gastroenterology 2005年第47期11卷 7545-7546页

作者： Norihiko Yamamoto Kazumoto Murata Takeshi Nakano The First Department of Internal Medicine Mie University School of MedicineTsuMieJapan

A 53-year-old man with a history of blood transfusion at the age of 20 was admitted to our hospital because of liver dysfunction. He had bronchial asthma when he was 18 years old, which naturally resolved within 2 years. However, his bronchial asthma recurred at the age of 45 and was treated with oral theophylline. He was diagnosed as having chronic hepatitis C based on the histological and clinical findings, and then interferon (IFN) therapy was administered. The frequency of bronchial asthma attack was gradually decreasing after IFN therapy with marked improvement of hypereosinophilia. He achieved sustained viral response (SVR) and his bronchial asthma did not worsen even after the cessation of IFN. Hepatitis C virus (HCV) infection and IFN therapy were considered in the remission of asthma in this case. HCV infection could be the cause of bronchial asthma, especially in patients with late appearance of asthma.

关键词： bronchial asthma Chronic hepatitis C IFN therapy

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Regulating effect of glycyrrhetinic acid on bronchial asthma smooth muscle proliferation and apoptosis as well as inflammatory factor expression through ERK1/2 signaling pathway

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Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1172-1176页

作者： Tao Zhang Jia-Yi Liao Li Yu Guo-Sheng Liu Department of Pediatrics the First Affiliated HospitalJinan UniversityGuangzhouChina Department of Respiration Guangzhou Yuexiu District Children's HospitalGuangzhouChina Department of Pediatrics Guangzhou First People's Hospital

Objective: To study the influence of glycyrrhetinic acid(GA) on bronchial asthma(BA)smooth muscle proliferation and apoptosis as well as inflammatory factor expression and its molecular ***: Male SD guinea pigs were selected and made into asthma models, bronchial asthma smooth muscle cells were cultured and divided into BA group, GA group and GA + LM group that were treated with serum-free RPMI1640 culture medium, serumfree RPMI1640 culture medium containing 50 ng/mL glycyrrhetinic acid, serum-free RPMI1640 culture medium containing 50 ng/mL glycyrrhetinic acid and 100 ng/mL LM22B-10 respectively; normal guinea pigs were collected and bronchial smooth muscle cells were cultured as control group. The cell proliferation activity as well as the expression of proliferation and apoptosis genes, inflammatory factors and p-ERK1/2 was ***: Proliferation activity value and m RNA expression of Bcl-2, TNF-α, IL-4, IL-6,YKL-40, protein expression of p-ERK1/2 of airway smooth muscle cell in BA group were significantly higher than those of control group while m RNA expression levels of Bax,caspase-9 as well as caspase-3 were significantly lower than that of control group(P bronchial smooth muscle cells and reduce the expression of inflammatory fa

关键词： bronchial asthma Glycyrrhetinic acid Extracellular signal-regulated kinase 1/2 Apoptosis Inflammatory factors

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Clarifying the relationship and analyzing the influential factors of bronchial asthma in children with attention-deficit hyperactivity disorder

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World Journal of Psychiatry 2024年第4期14卷 513-522页

作者： Gui-Xia Wang Xiao-Ying Xu Xi-Qing Wu Department of Infectious Diseases Dongying People’s HospitalDongying 257000Shandong ProvinceChina Department of Children's Health Dongying People’s HospitalDongying 257000Shandong ProvinceChina Department of Children's Health Shengli Oilfield Central HospitalDongying 257000Shandong ProvinceChina

BACKGROUND bronchial asthma is closely related to the occurrence of attention-deficit hyperactivity disorder(ADHD)in children,which can easily have adverse effects on children’s learning and social *** have shown that childhood asthma can increase the risk of ADHD and the core symptoms of *** with children with ADHD alone,children with asthma and ADHD are more likely to show high levels of hyperactivity,hyperactive-impulsive and other externalizing behaviors and anxiety in clinical practice and have more symptoms of somatization and emotional *** To explore the relationship between ADHD in children and bronchial asthma and to analyze its influencing *** This retrospective cohort study was conducted at Dongying People's Hospital from September 2018 to August *** diagnosed with ADHD at this hospital were selected as the ADHD group,while healthy children without ADHD who underwent physical examinations during the same period served as the control *** and parental data were collected for all participating children,and multivariate logistic regression analysis was employed to identify risk factors for comorbid asthma in children with *** differences were detected between the ADHD group and the control group in terms of family history ofasthma and allergic diseases, maternal complications during pregnancy, maternal use of asthma and allergymedications during pregnancy, maternal anxiety and depression during pregnancy, and parental relationshipstatus (P asthma, resulting in a comorbidityrate of 13.66% (25/183), compared to the comorbidity rate of 2.91% (16/549) among the 549 children in the controlgroup. The difference in the asthma comorbidity rate between the two groups was statistically significant (P asthma

关键词： Attention-deficit hyperactivity disorder Children bronchial asthma Risk factors Anxiety Depression

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Research on relationship between bronchial asthma and RSV bronchiolits

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吉林大学学报(医学版) 1995年第1期 45-48页

作者： Lijie,Zhao Guoku Liu Weimin, Wang Jianguo,Yi Shoumin,Fu Wenyong(The first Clinical college)

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ＲｅｓｅａｒｃｈｏｎｒｅｌａｔｉｏｎｓｈｉｐｂｅｔｗｅｅｎｂｒｏｎｃｈｉａｌａｓｔｈｍａａｎｄＲＳＶｂｒｏｎｃｈｉｏｌｉｔｉｓＹｕｃＬｉｊｉｅ，ＺｈａｏＧｕｏｋｕ，ＬｉｕＷｅｉｍｉｎ，ＷａｎｇＪｉａｎｇｕｏ，ＹｉＳｈｏｕｍｉｎ，ＦｕＷｅｎｙｏｎｇ（Ｔ...

关键词： respiratory syiicytial virus bronchiolitis bronchial asthma

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Systematic review of randomized controlled trials of traditional Chinese medicine treatment of non-acute bronchial asthma complicated by gastroesophageal reflux

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Journal of Traditional Chinese Medicine 2012年第1期32卷 12-18页

作者：赵宇昊刘兆兰李兰花蒋胜华史成和 School of Traditional Chinese Medicine Capital Medical University Centre for Evidence-based Chinese Medicine Beijing University of Chinese Medicine School of Public Health Weifang Medical CollegeWeifang Respiratory Department of Hospital Affiliated to Jining Medical College TCM Department of the Third Hospital Affiliated to Beijing University

OBJECTIVE:To assess the effectiveness and safety of Traditional Chinese Medicine(TCM) treatment of non-acute bronchial asthma complicated by gastroesophageal ***:We searched databases from MEDLINE,Cochrane Library,CNKI,VIP,CBM,Wanfang Data,and TCM Database *** randomized,controlled trials(RTCs) of TCM treatment of non-acute asthma complicated by gastroesophageal reflux were *** were independently collected by two *** standards for assessing quality described in the Cochrane Handbook for Systematic Reviews of Interventions were used to evaluate ***-analyses were conducted using RevMan 5.0.17 *** was assessed,and a corresponding effects model was used to merge and analyze *** used to evalu-ate curative effects were:clinical efficacy,symptom scores,pulmonary function values,and adverse *** was indicated using risk ratio(RR) or mean difference(MD),and 95% confidence intervals(CIs) were ***:Six RCTs were included,involving 304 patients with non-acute asthma complicated by gastroesophageal *** treatment groups received Chinese drugs alone or TCM combined with standard Western medical treatment,and the control groups received standard Western medical treatment *** Western medical treatment included anti-inflammatory drugs and bronchodilators for asthma,and drugs to promote gastric peristalsis and inhibit gastric acid production for gastroesophageal *** quality was low in all six *** RCTs showed that clinical efficacy was higher in the treatment group than in the control group(RR:1.43,95%CI:1.10 to 1.87 vs RR:1.51,95% CI:1.09 to 2.08).One RCT showed that the asthma score was lowered more effectively in the treatment group than in the control group(MD:-1.10,95% CI:-2.04 to-0.16).Two RCTs showed that the gastroesophageal reflux score was reduced more effectively in the treatment group than in the control group(RR:-3.70,95%

关键词： TCM bronchial asthma Gastroesophageal reflux Comparison of curative effects

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Efficacy and safety of salmeterol/fluticasone compared with montelukast alone (or add-on therapy to fluticasone) in the treatment of bronchial asthma in children and adolescents: a systematic review and meta-analysis

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Chinese Medical Journal 2021年第24期134卷 2954-2961页

作者： Xiao-Jian Zhou Zhen Qin Jiao Lu Jian-Guo Hong Department of Paediatrics Shanghai General HospitalShanghai Jiaotong UniversityShanghai 200080China

Background:Despite the recommendation of inhaled corticosteroids(ICSs)plus long-acting beta 2-agonist(LABA)and leukotriene receptor antagonist(LTRA)or ICS/LTRA as stepwise approaches in asthmatic children,there is a lack of published systematic review comparing the efficacy and safety of the two therapies in children and adolescents aged 4 to 18 *** study aimed to compare the safety and efficacy of salmeterol/fluticasone(SFC)***(MON),or combination of montelukast and fluticasone(MFC)in children and adolescents aged 4 to 18 years with bronchial ***:A systematic search was conducted in MEDLINE,EMBASE,the Cochrane Library,China BioMedical Literature Database,Chinese National Knowledge Infrastructure,VIP Database for Chinese Technical Periodical,and Wanfang for randomized controlled trials(RCTs)published from inception to May 24,*** are as follows:SFC ***,or combination of MFC,with no limitation of dosage or *** and secondary outcome measures were as follows:the primary outcome of interest was the risk of asthma *** outcomes included risk of hospitalization,pulmonary function,asthma control level,quality of life,and adverse events(AEs).A random-effects(I^(2)≥50%)or fixed-effects model(I^(2)asthma exacerbation in the SFC *** for secondary outcome,SFC showed a significant improvement of peak expiratory flow(PEF)%pred after 4 weeks compared with MFC(mean difference[MD]:5.45;95%confidence interval[CI]:1.57-9.34;I^(2)=95%;P=0.006).

关键词： bronchial asthma Fluticasone/salmeterol Montelukast Systematic review Pediatric

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San-Ao Decoction (三拗汤) Regulates Urine Volume on bronchial asthma Model Mice

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Chinese Journal of Integrative Medicine 2021年第3期27卷 212-219页

作者： WANG Min SUN Yan ZHANG Shu-jing GAO Yu-shan WEI Ya-nan ZHAO Peng-na LIU Miao YANG Jia-min ZHENG Feng-jie XU Hong LI Yu-hang School of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

Objective To observe the effect of San-Ao Decoction(三拗汤,SAD)on water metabolism of bronchial asthra model *** Forty-five female BALB/c mice were randomly divided into control,model and SAD groups by a random number table,15 mice in each group.A composite method with ovalbumin(OVA)sensitization and challenge was developed to establish bronchial asthma *** in the control group were intraperitoneally injected with distilled water without aerosol inhalation *** day 15–22,0.3 mL SAD was administered via gastric route in SAD group,one time per day,while an equivalent volume of normal saline was used for gastric administration in the control and model *** in airway resistance in the inspiratory phase(RI-R-Area)were detected using an AniRes2005 system,and 5-h urine output was collected by metabolic *** changes in lung and kidney were observed by hematoxylin-eosin *** expressions of aquaporin(AQP)1 and AQP2 in kidney were detected by reverse transcription-polymerase chain reaction,and the protein expressions of AQP1 and AQP2 in kidney were detected by ***-linked immune sorbent assay was used to detect the OVA-specific endothelium-1(ET-1),antidiuretic hormone(ADH),atrial natriuretic peptide(ANP),prostaglandin E_(2)(PGE_(2)),and angiotensin II(Ang II)levels in serum,lung and kidney tissues,*** nitric oxide(NO)contents in serum,lung,and kidney tissues were tested by chemical method,*** Compared with the control group,the serum IgE level in model group increased(P<0.01).Following the pathologic changes in lung tissue,no significant change in kidney tissue was observed among 3 *** with the control group,the mice in the model group showed elevated airway resistance during inhalation phase,higher mRNA and protein expression levels on AQP1 and AQP2 in kidney tissue and higher ET-1 levels in serum,lung and kidney tissues,ADH and ANP in lung and serum,PGE

关键词： regulation of fluid passage urine volume aquaporin San-Ao Decoction bronchial asthma

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