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Transarterial embolization is an acceptable bridging therapy to hepatocellular carcinoma prior to liver transplantation

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World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-Silva Leandro A Scaffaro Mauricio Farenzena Lucas Prediger Rafaela K Silva Flávia Heinz Feier Tomaz J M Grezzana-Filho Pablo D Rodrigues Alexandre de Araujo Mario Reis Alvares-da-Silva Roberta C Marchiori Cleber Rosito Pinto Kruel Marcio Fernandes Chedid Department of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive malignant neoplasm that requires liver transplantation(LT).Despite patients with HCC being prioritized by most organ allocation systems worldwide,they still have to wait for long periods.Locoregional therapies(LRTs)are employed as bridging therapies in patients with HCC awaiting LT.Although largely used in the past,transarterial embolization(TAE)has been replaced by transarterial chemoembolization(TACE).However,the superiority of TACE over TAE has not been consistently shown in the literature.AIM To compare the outcomes of TACE and TAE in patients with HCC awaiting LT.METHODS All consecutive patients with HCC awaiting LT between 2011 and 2020 at a single center were included.All patients underwent LRT with either TACE or TAE.Some patients also underwent percutaneous ethanol injection(PEI),concom-itantly or in different treatment sessions.The choice of LRT for each HCC nodule was determined by a multidisciplinary consensus.The primary outcome was waitlist dropout due to tumor progression,and the secondary outcome was the occurrence of adverse events.In the subset of patients who underwent LT,complete pathological response and post-transplant recurrence-free survival were also assessed.RESULTS Twelve(18.5%)patients in the TACE group(only TACE and TACE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tumor progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TACE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TACE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Among these patients,complete pathological response was detected in 7(14.6%)and 9(31%)patients in the TACE and TAE groups,respectively(P=0.145).Post-LT,HCC recurred in 9(18.8%)and 4(13.8%)patients in the TACE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was similar between the groups(P log-rank test=0.71).CONCL

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy bridging

Artificial intelligence for science-bridging data to wisdom

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The Innovation 2023年第6期4卷 21-22页

作者： Yongjun Xu Fei Wang Zhulin An Qi Wang Zhao Zhang Institute of Computing Technology Chinese Academy of SciencesBejjing 100190China

INTRODUCTION.Throughout the scientific discoveries of human history,research paradigms have undergone profound changes.'As shown in Figure 1,from the empirical paradigm,which relies on experimental observation,to the theoretical paradigm,which is based on theoretical deduction,and further to the computational para-digm,which is associated with simulation and emulation,and finally to the data-driven paradigm,which is grounded in human-machine object integration,every transformation of scientific paradigm has brought about a major leap in science and technology.

关键词： technology. Figure bridging

A High Spatiotemporal Iontronic Single-Cell Viscometer

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Research 2022年第4期2022卷 239-247页

作者： Tianyang Zhang Siyuan Yu Bing Wang Yitong Xu Xiaomei Shi Weiwei Zhao Dechen Jiang Hongyuan Chen Jingjuan Xu State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China

Ideal single-cell viscometer has remained unachieved,leaving a gap in current palette of single-cell nanotools.Information of single-cell viscosity could contribute to our knowledge of fundamental biological processes,e.g.,mass diffusion,biochemical interaction,and cellular responses to many diseases and pathologies.Although advances have been made to this end,existing methods generally suffer from limitations,e.g.,low spatiotemporal resolution.Here,we describe a high spatiotemporal iontronic single-cell viscometer that operates upon a patch clamp integrated with double-barreled nanopores separated by a septum of ca.32 nm.The system enables reversible electroosmotic manipulation of the adjacent small fluid bridging two nanopores,the viscous alternation of which could be sensitively monitored by the ionic responses.In practical cellular studies,significantly,our findings reveal not only the less deviated medium viscosities than those of lysosomes and mitochondria but also the highest viscosities in the near-nuclear region than those of mitochondrion-dense and lysosome-dense regions.This work has provided an accessible single-cell viscometer and enriched the armory of single-cell nanotools.

关键词： pores viscosity bridging

Full-scale ab initio simulations of laser-driven atomistic dynamics

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npj Computational Materials 2023年第1期9卷 190-196页

作者： Qiyu Zeng Bo Chen Shen Zhang Dongdong Kang Han Wang Xiaoxiang Yu Jiayu Dai College of Science National University of Defense Technology410073 ChangshaHunanChina Hunan Key Laboratory of Extreme Matter and Applications National University of Defense Technology410073 ChangshaChina Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics100088 BeijingChina

The coupling of excited states and ionic dynamics is the basic and challenging point for the materials response at extreme conditions.In the laboratory,the intense laser produces transient nature and complexity with highly nonequilibrium states,making it extremely difficult and interesting for both experimental measurements and theoretical methods.With the inclusion of laser-excited states,we extend an ab initio method into the direct simulations of whole laser-driven microscopic dynamics from solid to liquid.We construct the framework of combining the electron-temperature-dependent deep neural-network potential energy surface with a hybrid atomistic-continuum approach,controlling non-adiabatic energy exchange and atomistic dynamics,which enables consistent interpretation of experimental data.By large-scale ab initio simulations,we demonstrate that the nonthermal effects introduced by hot electrons play a dominant role in modulating the lattice dynamics,thermodynamic pathway,and structural transformation.We highlight that the present work provides a path to realistic computational studies of laser-driven processes,thus bridging the gap between experiments and simulations.

关键词： dynamics excited bridging

To bridge or not to bridge:summary of the new evidence in endovascular stroke treatment

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Stroke & Vascular Neurology 2022年第3期7卷 179-181页

作者： Anna Podlasek Permesh Singh Dhillon Waleed Butt Iris Q Grunwald Timothy J England Tayside Innovation MedTech Ecosystem(TIME) University of DundeeDundeeUK NIHR Nottingham Biomedical Research Centre University of NottinghamNottinghamUK Interventional Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Interventional Neuroradiology University Hospitals Birmingham NHS TrustBirminghamUK Stroke Division of Mental Health and Clinical NeurosciencesSchool of MedicineUniversity of NottinghamNottinghamUK Stroke University Hospitals of Derby and Burton NHS Foundation TrustDerbyUK

WHAT IS ALREADY KNOWN Recently published summaries and meta-analyses of four randomised controlled trials(RCTs)1-5 comparing direct mechan-ical thrombectomy(dMT)and bridging therapy with intravenous(IV)thrombolytics(alteplase)suggested that dMT is non-inferior to bridging therapy to achieve good functional outcome 3 months after stroke(modified Rankin Score 0-2)with the non-inferiority margin(NIM)<−5%.

关键词： intravenous bridging treatment

Nanozymes: an emerging field bridging nanotechnology and enzymology

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Science China(Life Sciences) 2019年第11期62卷 1543-1546页

作者： Xiangqin Meng Kelong Fan Xiyun Yan School of Future Technology University of Chinese Academy of SciencesBeijing 101408China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Joint Laboratory of Nanozymes in Zhengzhou University Academy of Medical SciencesZhengzhou University40 Daxue RoadZhengzhou 450052China

Nanozyme,a class of nanomaterials with intrinsic enzymelike properties,is a new concept which has been included in the Encyclopedia of China and the textbook of enzyme engineering.Since the first evidence published in 2007(Gao et al.,2007),great progress has been achieved in the study of nanozyme from new concept,new material to its new application,and it becomes an emerging field bridging nanotechnology and biology(Gao and Yan,2016).

关键词： bridging field intrinsic

Tuning the Mottness in Sr_(3)Ir_(2)O_(7)via bridging Oxygen Vacancies

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Chinese Physics Letters 2023年第3期40卷 25-30页

作者：徐妙邹昌炜龚本超贾可叶树森郝镇齐刘凯石友国卢仲毅蔡鹏王亚愚 State Key Laboratory of Low Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Renmin University of ChinaBeijing 100872China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China Frontier Science Center for Quantum Information Beijing 100084China

The electronic evolution of Mott insulators into exotic correlated phases remains puzzling,because of electron interaction and inhomogeneity.Introduction of individual imperfections in Mott insulators could help capture the main mechanism and serve as a basis to understand the evolution.Here we utilize scanning tunneling microscopy to probe the atomic scale electronic structure of the spin-orbit-coupling assisted Mott insulator Sr_(3)Ir_(2)O_(7).It is found that the tunneling spectra exhibit a homogeneous Mott gap in defect-free regions,but near the oxygen vacancy in the rotated Ir O_(2)plane the local Mott gap size is significantly enhanced.We attribute the enhanced gap to the locally reduced hopping integral between the 5d electrons of neighboring Ir sites via the bridging planar oxygen p orbitals.Such bridging defects have a dramatic influence on local bandwidth,thus provide a new way to manipulate the strength of Mottness in a Mott insulator.

关键词： bridging tunneling utilize

bridging the gap between research and schematic design phases in teaching architectural graduation projects

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Frontiers of Architectural Research 2020年第1期9卷 82-105页

作者： Eman S.AboWardah Architectural Engineering Department Prince Sultan UniversityRiyadh 11586Saudi Arabia Architectural Engineering Department Tanta UniversityTanta 31512Egypt

The architectural design studio course is generally considered the backbone of any architectural curriculum and follows a particular method of problem solving,which makes it a distinctive course.Graduation projects in most of the architectural programs are divided into two main phases,namely,research and project phases.Students generate many findings from the research phase that are considered challenges.The research problem emerges when students finish writing the research thesis,and most face difficulty in translating the collected data into actions to engage the initial idea of the project.Therefore,this study aims to high-light the transitional stage between the research and schematic design phases,which is described in this study as the"predesign bridging phase."The goal is to propose a practical strategy for bridging the gap between the research and schematic design phases to facilitate derivation of the design concept from different output variables to enable the creation of a suitable architectural morphological language.The study adopts two research methods.One is proposing a new pedagogical framework and applying it to the architectural graduation design studio at Prince Sultan University in Riyadh,Saudi Arabia.The other is conducting a survey among students to evaluate the efficiency of the proposed framework in helping them bridge the gap between the research and schematic design phases.Descriptive and inferential statistics analysis methods are used to analyze the research data and study the correlation between the reflection of the new applied framework in the predesign bridging phase and the students'satisfaction toward the final projects'product and performance in the final critique.This study ends with a conclusion on how the applied teaching strategies facilitate the project starting point and raises the importance of proposing and testing new assessment strategies that are suitable for each phase in the graduation design studio.

关键词： Predesign bridging phase Graduation project Problem solving Mind mapping Student self-criticism Peer criticism

Chemoattractive capacity of different lengths of nerve fragments bridging regeneration chambers for the repair of sciatic nerve defects

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Neural Regeneration Research 2012年第29期7卷 2293-2298页

作者： Jiren Zhang Yubo Wang Jincheng Zhang Department of Hand Surgery First Affiliated Hospital of Liaoning Medical UniversityJinzhou 121001Liaoning ProvinceChina

A preliminary study by our research group showed that 6-mm-long regeneration chamber bridging is equivalent to autologous nerve transplantation for the repair of 12-mm nerve defects. In this study, we compared the efficacy of different lengths （6, 8, 10 mm） of nerve fragments bridging 6-mm regeneration chambers for the repair of 12-mm-long nerve defects. At 16 weeks after the regeneration chamber was implanted, the number, diameter and myelin sheath thickness of the regenerated nerve fibers, as well as the conduction velocity of the sciatic nerve and gastrocnemius muscle wet weight ratio, were similar to that observed with autologous nerve transplantation. Our results demonstrate that 6-, 8-and 10-mm-long nerve fragments bridging 6-mm regeneration chambers effectively repair 12-mm-long nerve defects. Because the chemoattractive capacity is not affected by the length of the nerve fragment, we suggest adopting 6-mm-long nerve fragments for the repair of peripheral nerve defects.

关键词： nerve fragment length nerve regeneration chamber bridging long nerve defect chemotactic ability neural regeneration