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Tim-3 promotes cell aggressiveness and paclitaxel resistance through NF-κB/STAT3 signalling pathway in breast cancer cells

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Chinese Journal of Cancer Research 2020年第5期32卷 564-579页

作者： Yizi Cong Yuxin Cui Shiguang Zhu Jianqiao Cao Haidong Zou Tracey AMartin Guangdong Qiao Wenguo Jiang Zhigang Yu Department of breast Surgery The Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033China Department of breast Surgery The Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantai 264001China Cardiff China Medical Research Collaborative School of MedicineCardiff UniversityCardiffCF144XNUK

Objective:Although T-cell immunoglobulin and mucin-domain containing molecule-3(Tim-3)has been recognized as a promising target for cancer immunotherapy,its exact role in breast cancer has not been fully ***:Tim-3 gene expression in breast cancer and its prognostic significance were *** mechanisms were then explored in vitro by establishing Tim-3-overexpressing breast cancer ***:In a pooled analysis of The Cancer Genome Atlas(TCGA)database,Tim-3 gene expression levels were significantly higher(Pbreast cancer tissue,compared with normal ***-3 was a prognosis indicator in breast cancer patients[relapse-free survival(RFS),P=0.004;overall survival(OS),P=0.099].Tim-3 overexpression in Tim-3 low breast cancer cells promoted aggressiveness of breast cancer cells,as evidenced by enhanced proliferation,migration,invasion,tight junction deterioration and tumor-associated tubal ***-3 also enhanced cellular resistance to ***,Tim-3 exerted its function by activating the NF-κB/STAT3 signalling pathway and by regulating gene expression[cyclin D1(CCND1),C-Myc,matrix metalloproteinase-1(MMP1),TWIST,vascular endothelial growth factor(VEGF)upregulation,concomitant with Ecadherin downregulation).Lastly,Tim-3 downregulated tight junction-associated molecules zona occludens(ZO)-2,ZO-1 and occludin,which may further facilitate tumor ***:Tim-3 plays an oncogenic role in breast cancer and may represent a potential target for antitumor therapy.

关键词： breast neoplasm hepatitis A virus cellular receptor 2 tight junction aggression chemoresistance

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Neoadjuvant targeted therapy for apocrine carcinoma of the breast:A case report

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World Journal of Clinical Cases 2020年第23期8卷 6036-6042页

作者： Ping Yang Shu-Jia Peng Yan-Ming Dong Lin Yang Zhen-Yu Yang Xi-E Hu Guo-Qiang Bao Department of General Surgery Tangdu HospitalAir Force Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

BACKGROUND Apocrine carcinoma of the breast is a special type of invasive ductal carcinoma of the breast that is rare in clinical *** therapy,especially neoadjuvant targeted therapy,has rarely been reported for apocrine carcinoma of the *** SUMMARY A 63-year-old woman presented with apocrine carcinoma of the left breast underwent core needle *** patient was diagnosed with apocrine carcinoma by immunohistochemical staining and negative hormone status(estrogen receptor and progesterone receptor)but showed overexpression of human epidermal factor receptor 2(HER-2).Moreover,positive expression of androgen receptor(approximately 60%)and gross cystic disease fluid protein 15 was *** patient was treated with neoadjuvant targeted therapy consisting of the TCH regimen(docetaxel,carboplatin area under curve 6 and trastuzumab)every 21 *** mass in the left breast was significantly reduced,and pain in the breast and left upper arm also *** HER-2 positive apocrine carcinoma of the breast can be improved by neoadjuvant chemotherapy combined with targeted therapy.

关键词： breast neoplasm ErbB-2 receptor Targeted therapy Case report Apocrine gland Neoadjuvant therapies

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Male metaplastic breast cancer with poor prognosis:A case report

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World Journal of Clinical Cases 2022年第15期10卷 4964-4970页

作者： Hyun Yul Kim Seungju Lee Dong-il Kim Chang Shin Jung Jee Yeon Kim Kyung Jin Nam Ki Seok Choo Youn Joo Jung Department of Surgery Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea Department of Pathology Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea Department of Radiology Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea

BACKGROUND Metaplastic breast cancer(MBC)is a rare subtype of breast *** constitute less than 1%of breast cancer cases and are much rarer in *** are few reports of MBC because of its ***,an aggressive type of cancer,is refractory to common treatment modalities of breast cancer and has a poor *** SUMMARY We report a case of MBC in a 78-year-old *** visited our clinic with a palpable mass on the left breast with no masses in the axillary *** had previously undergone robot-assisted laparoscopic radical prostatectomy for prostate cancer,but there was no family history of *** breast mass was visible on ultrasonography,mammography,and magnetic resonance imaging,and chest computed tomography revealed a lung mass in the posterior basal segment of the right lower *** patient was diagnosed with metaplastic carcinoma on core needle biopsy with lung *** mastectomy with sentinel lymph node biopsy and video-assisted segmentectomy of the right lung was ***,multiple metastases appeared 3 mo after surgery in the brain,chest,and abdomen,and the patient died 5 mo after the initial *** MBC is an aggressive and extremely rare breast cancer *** case reports are needed to determine the optimal treatment.

关键词： breast neoplasm Male Triple-negative breast cancer Metaplastic breast cancer Adjuvant treatment Case report

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A remote,fully oriented personalized program of physical exercise for women in follow-up after breast cancer treatment improves body composition and physical fitness

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Sports Medicine and Health Science 2023年第2期5卷 128-136页

作者： Edipo G.França-Lara Saulo H.Weber Ricardo A.Pinho JoséClaudio Casali-da-Rocha Selene Elifio-Esposito Graduate Program in Health Sciences School of Medicine and Life SciencesPontifícia Universidade Católica do ParanáCuritibaPRBrazil School of Medicine and Life Sciences Pontifícia Universidade Católica do ParanáCuritibaPRBrazil Oncogenetics Department A.C.Camargo Cancer CenterSão PauloSPBrazil Hospital Erasto Gaertner CuritibaPRBrazil

This study aimed to evaluate the efficacy of an individualized remote exercise program on the improvement of body composition and physical fitness of a heterogeneous group of patients who completed breast cancer *** prospective study included 107 women aged 18 to 60,shortly after curative treatment for localized breast cancer,at the Erasto Gaertner Cancer Hospital(HEG)in Curitiba,PR,*** composition,maximal oxygen consumption,and muscle resistance were evaluated after nine months of intervention while considering adherence to the program,level of physical activity,presence of binge eating disorder,tumor classification,and treatment ***-eight women(72.8%)adhered to the training *** participants showed significant changes in body mass([-4.3±3.6]kg;pbreast cancer surveillance,regardless of pathological history or treatment.

关键词： breast neoplasm Exercise training Physical therapy modalities Body weight changes Physical functional performance

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COMPARISON　OF　INFRARED　LIGHTSCANNING　AND　MAMMOGRAPHY　IN　breast　CANCER　DETECTION

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Chinese Journal of Cancer Research 1995年第4期7卷 308-310页

作者：唐瑞英胡永升徐光炜 Beijing Institute for Cancer Research The School of Oncology Beijing Medical University Beijing

Purpose: This study is in an attempt to assess the diagnostic accuracy of infrared lightscanning by comparing with that of mammograpby- Methods: A total of 104 patients had been examined by both mammography and infrared lightscanning before *** Patients were divided into two groups: cancer and non cancer. The diagnostic accuracy of these two modalities were calculated. Results: Of 104 Patients, 43 had breast cancer and 61 had benign lesions, the sensitivity and specificity for mammography were 84% and 83%, 82% and 77% for infrared lightscanning. The predictive values of positivity for mammograpby and lightscanning were 80% and 70%, the negative Predictive value for these two modalities were both 87%. Conclusion: Infrared lightscanning,being of assistance to mammography, could enhance sensitivity and predictive values of positivity in detecting breast cancer, especially, in mammographically dense breast.

关键词： breast neoplasm Mammography Imaging diagnosis Evaluation study

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Fatigue and Quality of Life of Women Undergoing Chemotherapy or Radiotherapy for breast Cancer

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Clinical oncology and cancer researeh 2009年第3期6卷 179-185页

作者： Winnie K.W.So Gene Marsh W.M.Ling F.Y.Leung Joe C.K.Lo Maggie Yeung George K.H.Li Department of Nursing Studies The University of Hong Kong School of Nursing University of Colorado Health Science Center Nurse Specialist Department of Clinical OncologyPamela Youde Nethersole Eastern Hospital Infection Control Unit Princess Margaret Hospital Oncology Department Princess Margaret Hospital Clinical Oncology Department Tuen Mun Hospital Department of Surgery Queen Mary Hospital

OBJECTIVE To examine fatigue and quality of life (QOL) inbreast cancer patients undergoing chemotherapy or *** A self-report survey derived from the Chineseversion of Brief Fatigue Inventory, the Functional Assessmentof Chronic Illness Therapy for breast Cancer, and the MedicalOutcomes Study Social Support Survey. Descriptive statisticswas used to examine the intensity of fatigue and the prevalenceof severe fatigue. Multivariate analysis of variance was used todetermine factors that affect the five domains of QOL among *** The majority of the participants (n = 261) perceiveda mild level of fatigue, but 35.6% of them suffered severe *** had a significantly negative association with all domainsof QOL except social/family wellbeing. The participants whowere receiving chemotherapy, undergoing curative treatment andhaving inadequate social support were more likely to have poorerQOL in all five domains (after adjustment for age).CONCLUSION Although the majority of the participantsexperienced a mild level of fatigue, there was a substantial groupof breast cancer patients who perceived their fatigue as severe. Thefindings of this study showed that fatigue had a detrimental effecton the various aspects of the participants' QOL. Demographic andclinical characteristics of breast cancer patients who were at riskof getting poorer QOL were identified. The results of the studydemonstrate that we should enhance healthcare professionals'awareness of the importance of symptom assessment, andprovide them with information for planning effective symptom-management strategies among this study population.

关键词： breast neoplasm fatigue quality of life drug therapy.

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Relationship between Lymphatic Vessel Density and Lymph Node Metastasis of Invasive Micropapillary Carcinoma of the breast

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Chinese Journal of Clinical Oncology 2006年第1期3卷 15-19页

作者： Xiaojing Guo Ling Chen Ronggang Lang Yu Fan Li Fu Department of breast Pathology and Research Tianjin Medical University Cancer Hospital Tianjin 300060 China

OBJECTIVE To investigate the relationship between lymphatic vessel density and lymph node metastasis of invasive micropapillary carcinoma (IMPC) of the breast. METHODS The immunohistochemical study for vascular endothelial growth factor-c (VEGF-C), VEGF Receptor-3 (VEGFR-3) and lymphatic vessel density of 51 cases of IMPC were performed, and lymph node metastases were examined by microscopic analysis of these cases. RESULTS In IMPC, VEGF-C was expressed in the cytoplasm and/or on the membrane of the tumor cells, and the expression of VEGF-C showed a positive correlation with lymph node metastasis (P<0.01). Lymphatic vessel density was determined by the number of micro-lymphatic vessels with VEGFR-3 positive staining. Lymphatic vessel density was positively correlated with VEGF-C expression (P<0.01) and lymph node metastasis (P<0.01). The percentage of IMPC in the tumor was not associated with the incidence of lymph node metastasis. The metastatic foci in lymph nodes were either pure or predominant micropapillary carcinoma. CONCLUSION The results suggested that VEGF-C overexpression stimulated tumor lymphangiogenesis, and the increased lymphatic vessel density may be the key factor that influenced lymph node metastasis of IMPC.

关键词： breast neoplasm invasive micropapillary carcinoma (IMPC) vascular endothelial growth factor (VEGF) lymph node metastasis.

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DETECTION OF MICROMETASTASES IN AXILLARY LYMPH NODES OF NODE-NEGATIVE breast CANCER PATIENTS AND ITS CLINICAL SIGNIFICANCE

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Chinese Journal of Cancer Research 1997年第2期9卷 146-149页

作者：吴进冬余子豪李国民张宏图

Monoclonal antibodies against cytokeratin(AE1/AE3) were applied as a prohe, using APAAPimmunohistochemistry technique to detect 635 lymphnodes from 45 breast cancer patients with negative lymphnodes. Micrometastases were identified in 14 lymph nodesof 9 cascs (20o/o). A significant difference was foundbetwecn cytokeratin staining positive group andcytokeratin staining negative group in disease-free andover-all Kaplan-Meier survival curves. The detection ofmicromctastases had more clinical value for T1 and T2patients. One of 2 T1 cytokeratin positive cases relapsedwhile only 1 of 19 T1 negative cases relapsed within 5years; three of 5 T2 cytokeratin positive cases relapsedwhile 1 of 17 negative cases did. The prescnce ofmicromctastases had the same value in predicting localrecurrence and distant metastases.

关键词： breast neoplasm Keratin Lymphatic metastasis Immunohistochemistry

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MECHANISM OF TAXOL-INDUCED APOPTOSIS IN HUMAN breast CANCER CELLS

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Chinese Journal of Cancer Research 1998年第1期10卷 34-38页

作者：陈丽荣郑树范伟民

Objective: To investigate the mechanism by which taxol induces apoptosis in human breast cancer cells. Methods: Cell morphology, agarose gel electrophoresis, flow cytometry, video time lapse monitor and Western blot were performed for investigating taxol induced apoptosis in human breast cancer cells (BCap 37). Results: BCap 37 cells treated with taxol (100 nm) under went the arrests of cell mitosis at metaphase of mitosis and induction of apoptosis. Apoptotic cells demonstrated cell shrinkage, condensation or fragmentation of chro mosomes. Nuclear DNA of apoptotic cells displayed ladder bands characteristic of internucleosomal DNA fragmentation. The expression of bcl 2, inhibitor of apotosis, was decreased with modification, while that of bax, inducer of apoptosis, increased only at early stage of the apoptotic pathway and decreased later. Conclusion: In human breast cancer cells the induction of apoptosis by taxol was closely associated with mitotic arrest of cell cycle, and altered expressions of bcl 2 and bax gene possibly played an important role in regulating taxol induced apoptosis.

关键词： Taxol breast neoplasm Apoptosis.

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EFFECT OF UP-REGULATION OF S-ADOMET SYNTHETASE ON TAXOL-INDUCED APOPTOSIS IN HUMAN breast CANCER CELLS

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Chinese Journal of Cancer Research 1998年第4期10卷 3-6页

作者：陈丽荣郑树范伟民张苏展

Objective: To investigate the gene regulation of taxolinduced apoptosis Methods: Northern blot hybridization, enzyme activity assay of S AdoMet synthetase and flow cytometry were performed in the investigation of expression in the mRNA level and biological action of S AdoMet synthetase in taxol induced apoptosis in human breast cancer cell line (BCap 37) Results: Up regulation of S AdoMet synthetase expression was resulted by taxol treatment and the expression peaked at 48 hours Moreover,the up regulation of S AdoMet synthetase was associated with cytotoxicity of anti microtubule agents including taxol and colchicine Inhibition rate of S AdoMet synthetase activity by 1% DMSO was 34% in taxol treated cells and 14% in taxol untreated cells compared to control groups, respectively Posttreatment with 1% DMSO following pretreatment with individual antitumor agent for 3 hrs promoted apoptotic cell death of taxol ,colchicine ,and adriamycin treated Bcap37 cells Conclusion : The induction of apoptosis enhanced by post treatment with DMSO in taxol treated cells is probably linked to its inhibition on enzyme activity of S AdoMet synthetase ,suggesting that the increased expression of S AdoMet synthetase possibly plays an important role in protecting cells from DNA fragmentation in taxol induced apoptosis Accepted July 26, 1998 This work was supported by the National High Biotechnology Foundation of China and a grant from the Natural Science Foundation of Zhejiang Province, China

关键词： breast neoplasm Taxol S AdoMet synthetase Apoptosis

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