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Decoding nervous system by single-cell RNA sequencing

Frontiers of Electrical and Electronic Engineering in China 2017年第3期5卷 210-214页

作者： Ganlu Hu Guang-Zhong Wang Key Laboratory of Computational Biology Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Background： Mammalian brain are composed of a large number of specialized cell types with diverse molecular composition, functions and differentiation potentials. The application of recently developed single-cell RNA sequencing （scRNA-seq） technology in this filed has provided us new insights about this sophisticated system, deepened our understanding of the cell type diversity and led to the discovery of novel cell types. Results： Here we review recent progresses of applying this technology on studying brain cell heterogeneity, adult neurogenesis as well as brain tumors, then we discuss some current limitations and future directions of using scRNA- seq on the investagation of nervous system. Conclusions： We believe the application of single-celi RNA sequencing in neuroscience will accelerate the progress of big brain projects.

关键词： single cell RNA-seq brain transcriptome brain cell types

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Genomics in Neurological Disorders

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Genomics, Proteomics & Bioinformatics 2014年第4期12卷 156-163页

作者： Guangchun Han Jiya Sun Jiajia Wang Zhouxian Bai Fuhai Song Hongxing Lei CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences University of Chinese Academy of Sciences Center of Alzheimer’s Disease Beijing Institute for Brain Disorders

Neurological disorders comprise a variety of complex diseases in the central nervous system, which can be roughly classified as neurodegenerative diseases and psychiatric disorders. The basic and translational research of neurological disorders has been hindered by the difficulty in accessing the pathological center （i.e., the brain） in live patients. The rapid advancement of sequencing and array technologies has made it possible to investigate the disease mechanism and biomarkers from a systems perspective. In this review, recent progresses in the discovery of novel risk genes, treatment targets and peripheral biomarkers employing genomic technologies will be dis- cussed. Our major focus will be on two of the most heavily investigated neurological disorders, namely Alzheimer＇s disease and autism spectrum disorder.

关键词： brain transcriptome Genome-wide associationstudy Whole exome sequencing Epigenome profiling Biomarker

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