Genomics in Neurological Disorders

作     者：Guangchun Han Jiya Sun Jiajia Wang Zhouxian Bai Fuhai Song Hongxing Lei 

作者机构：CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences University of Chinese Academy of Sciences Center of Alzheimer’s Disease Beijing Institute for Brain Disorders 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2014年第12卷第4期

页      面：156-163页

核心收录：

学科分类：07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 090102[农学-作物遗传育种] 0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0714[理学-统计学（可授理学、经济学学位）] 0703[理学-化学] 0901[农学-作物学] 100204[医学-神经病学] 0836[工学-生物工程] 0701[理学-数学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 10[医学] 

基　　金：supported by the grant from the National Basic Research Program of China (973 Program  Grant No. 2014CB964901) awarded to HL from the Ministry of Science and Technology of China 

主　　题：Brain transcriptome Genome-wide associationstudy Whole exome sequencing Epigenome profiling Biomarker 

摘      要：Neurological disorders comprise a variety of complex diseases in the central nervous system, which can be roughly classified as neurodegenerative diseases and psychiatric disorders. The basic and translational research of neurological disorders has been hindered by the difficulty in accessing the pathological center （i.e., the brain） in live patients. The rapid advancement of sequencing and array technologies has made it possible to investigate the disease mechanism and biomarkers from a systems perspective. In this review, recent progresses in the discovery of novel risk genes, treatment targets and peripheral biomarkers employing genomic technologies will be dis- cussed. Our major focus will be on two of the most heavily investigated neurological disorders, namely Alzheimer＇s disease and autism spectrum disorder.