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Assessment of structural brain changes in patients with type 2 diabetes mellitus using the MRI-based brain atrophy and lesion index

引用

Neural Regeneration Research 2022年第3期17卷 618-624页

作者： Heng Zhao Fang Wang Guang-Hua Luo Hao Lei Fei Peng Qiu-Ping Ren Wei Chen Yan-Fang Wu Li-Chun Yin Jin-Cai Liu Shi-Nong Pan Department of Radiology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Radiology The First Affiliated Hospital of University of South ChinaHengyangHunan ProvinceChina

Patients with type 2 diabetes mellitus(T2 DM) often have cognitive impairment and structural brain *** magnetic resonance imaging(MRI)-based brain atrophy and lesion index can be used to evaluate common brain changes and their correlation with cognitive function,and can therefore also be used to reflect whole-brain structural changes related to T2 DM.A total of 136 participants(64 men and 72 women,aged 55–86 years) were recruited for our study between January 2014 and December *** participants underwent MRI and Mini-Mental State Examination assessment(including 42 healthy control,38 T2 DM without cognitive impairment,26 with cognitive impairment but without T2 DM,and 30 T2 DM with cognitive impairment participants).The total and sub-category brain atrophy and lesion index scores in patients with T2 DM with cognitive impairment were higher than those in healthy *** in the brain atrophy and lesion index of gray matter lesions and subcortical dilated perivascular spaces were found between non-T2 DM patients with cognitive impairment and patients with T2 DM and cognitive *** adjusting for age,the brain atrophy and lesion index retained its capacity to identify patients with T2 DM with cognitive *** findings suggest that the brain atrophy and lesion index,based on T1-weighted and T2-weighted imaging,is of clinical value for identifying patients with T2 DM and cognitive *** matter lesions and subcortical dilated perivascular spaces may be potential diagnostic markers of T2 DM that is complicated by cognitive *** study was approved by the Medical Ethics Committee of University of South China(approval ***20131109003) on November 9,2013,and was retrospectively registered with the Chinese Clinical Trial Registry(registration *** CTR1900024150) on June 27,2019.

关键词： brain atrophy and lesion index cognitive impairments gray matter lesions magnetic resonance imaging Mini-Mental State Examination structural brain subcortical dilated perivascular spaces T1-weighted image T2-weighted image type 2 diabetes mellitus

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