Assessment of structural brain changes in patients with type 2 diabetes mellitus using the MRI-based brain atrophy and lesion index

作     者：Heng Zhao Fang Wang Guang-Hua Luo Hao Lei Fei Peng Qiu-Ping Ren Wei Chen Yan-Fang Wu Li-Chun Yin Jin-Cai Liu Shi-Nong Pan 

作者机构：Department of RadiologyShengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of RadiologyThe First Affiliated Hospital of University of South ChinaHengyangHunan ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第3期

页      面：618-624页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China,No.81271538 (to SNP) 345 Talent Project and the Natural Science Foundation of Liaoning Province of China,No.2019-ZD-0794 (to SNP) the Natural Science Foundation of Hunan Province of China,Nos.2017JJ2225 (to JCL),2018JJ2357 (to GHL) Hunan Provincial Science and Technology Innovation Program of China,No.2017SK50203 (to HZ) 

主　　题：brain atrophy and lesion index cognitive impairments gray matter lesions magnetic resonance imaging Mini-Mental State Examination structural brain subcortical dilated perivascular spaces T1-weighted image T2-weighted image type 2 diabetes mellitus 

摘      要：Patients with type 2 diabetes mellitus(T2 DM) often have cognitive impairment and structural brain *** magnetic resonance imaging(MRI)-based brain atrophy and lesion index can be used to evaluate common brain changes and their correlation with cognitive function,and can therefore also be used to reflect whole-brain structural changes related to T2 DM.A total of 136 participants(64 men and 72 women,aged 55–86 years) were recruited for our study between January 2014 and December *** participants underwent MRI and Mini-Mental State Examination assessment(including 42 healthy control,38 T2 DM without cognitive impairment,26 with cognitive impairment but without T2 DM,and 30 T2 DM with cognitive impairment participants).The total and sub-category brain atrophy and lesion index scores in patients with T2 DM with cognitive impairment were higher than those in healthy *** in the brain atrophy and lesion index of gray matter lesions and subcortical dilated perivascular spaces were found between non-T2 DM patients with cognitive impairment and patients with T2 DM and cognitive *** adjusting for age,the brain atrophy and lesion index retained its capacity to identify patients with T2 DM with cognitive *** findings suggest that the brain atrophy and lesion index,based on T1-weighted and T2-weighted imaging,is of clinical value for identifying patients with T2 DM and cognitive *** matter lesions and subcortical dilated perivascular spaces may be potential diagnostic markers of T2 DM that is complicated by cognitive *** study was approved by the Medical Ethics Committee of University of South China(approval ***20131109003) on November 9,2013,and was retrospectively registered with the Chinese Clinical Trial Registry(registration *** CTR1900024150) on June 27,2019.