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Negative cross-resistance of a pyrethroid-resistant Drosophila mutant to Phryma leptostachya-derived haedoxan A

Insect Science 2022年第3期29卷 817-826页

作者： Xingtao Qie Yuzhe Du Ahmed A.A.Aioub Ke Dong Zhaonong Hu Institution of Pesticide Science College of Plant ProtectionNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of botanical Pesticide R&D in Shaanxi Province YanglingShaanxi 712100China Southern Insect Management Research Unit Agriculture Research ServiceUnited States Department of Agriculture141 Experiment Station RoadStonevilleMS 38776USA Plant Protection Department Faculty of AgricultureZagazig UniversityZagazig44511 Egypt Department of Biology Duke UniversityDurhamNC 27708USA

Voltage-gated sodium channels are the primary target of pyrethroid *** in sodium channel confer knockdown resistance(kdr)to pyrethroids in various arthropod *** A(HA)is the major insecticidal component from Phryma *** has been shown that HA alters electrical responses at the Drosophila neuromuscular junction and modifies the gating properties of cockroach sodium channels expressed in Xenopus ***,whether sodium channel mutations that confer pyrethroid resistance also affect the action of HA is *** this study,we conducted bioassays using HA and permethrin in two Drosophila melanogaster strains:w^(1118),an insecticide-susceptible strain,and para^(tsl),a pyrethroid-resistant strain due to a I265N mutation in the sodium channel,and identified a new case of negative cross-resistance(NCR)between permethrin and *** para^(tsl) larvae and adults were more resistant to permethrin,as ***,both para^(tsl) larvae and adults were more sensitive to HA compared to w^(1118).We confirmed that the I265N mutation reduced the sensitivity to permethrin of a Drosophila sodium channel variant,DmNa_(v)22,expressed in Xenopus ***,the I265N mutation also abolished the effect of HA on sodium *** characterization showed that I265 on the sodium channels is critical for the action of both pyrethroids and HA on sodium channels,pointing to an overlapping mode of action between pyrethroids and HA on the sodium ***,our results suggest an I265N-independnt mechanism(s)in para^(tsl) flies that is responsible for the NCR between permethrin and HA at the whole insect level.

关键词： botanical insecticide haedoxan A insecticidal mechanism negative crossresistance permethrin voltage-gated sodium channel

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Role of DSC1 in Drosophila melanogaster synaptic activities in response to haedoxan A

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Insect Science 2023年第6期30卷 1677-1688页

作者： Xingtao Qie Yaxin Ren Xueting Chen Yuzhe Du Ke Dong Zhaonong Hu Institution of Pesticide Science College of Plant ProtectionNorthwest A&F UniversityYanglingShaanxi ProvinceChina Key Laboratory of botanical Pesticide R&D in Shaanxi Province YanglingShaanxi ProvinceChina Department of Plant Protection College of Plant ProtectionShanxi Agricultural UniversityTaiguShanxi ProvinceChina Southern Insect Management Research Unit Agricultural Research ServiceUnited States Department of AgricultureStonevilleMSUSA Department of Biology Duke UniversityDurhamNCUSA Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau Ministry of AgricultureNorthwest A&F UniversityYanglingShanxi ProvinceChina

Drosophila sodium channel 1 (DSC1) encodes a voltage-gated divalent cation channel that mediates neuronal excitability in insects. Previous research revealed that DSC1 knockout Drosophila melanogaster conferred different susceptibility to insecticides, which indicated the vital regulation role of DSC1 under insecticide stress. Haedoxan A (HA) is a lignan compound isolated from Phryma leptostachya, and we found that HA has excellent insecticidal activity and is worthy of further study as a botanical insecticide. Herein, we performed bioassay and electrophysiological experiments to test the biological and neural changes in the larval Drosophila with/without DSC1 knockout in response to HA. Bioassay results showed that knockout of DSC1 reduced the sensitivity to HA in both w1118 (a common wild-type strain in the laboratory) and parats1 (a pyrethroid-resistant strain) larvae. Except for parats1/DSC1−/−, electrophysiology results implicated that HA delayed the decay rate and increased the frequency of miniature excitatory junctional potentials of Drosophila from w1118, parats1, and DSC1−/− strains. Moreover, the neuromuscular synapse excitatory activities of parats1/DSC1−/− larvae were more sensitive to HA than DSC1−/− larvae, which further confirmed the functional contribution of DSC1 to neuronal excitability. Collectively, these results indicated that the DSC1 channel not only regulated the insecticidal activity of HA, but also maintained the stability of neural circuits through functional interaction with voltage-gated sodium channels. Therefore, our study provides useful information for elucidating the regulatory mechanism of DSC1 in the neural system of insects involving the action of HA derived from P. leptostachya.

关键词： botanical insecticide Drosophila sodium channel 1(DSCI) insect nervous system neuromuscular synapse activity regulatory

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Insecticidal Activity and Physicochemical Characterization of Nanoparticles from Foliar Extract of Capsicum chinense

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Journal of Renewable Materials 2023年第11期11卷 3933-3943页

作者： Arnoldo E.Alfaro-Corres Daniel Gonzalez-Mendoza Esau Ruiz-Sanchez Carlos Ail-Catzin Benjamin Valdez-Salas Federico Gutierrez-Miceli Arturo Reyes-Ramirez Jacques Fils Pierre Division of Postgraduate Studies and Research Tecnologico Nacional de MéxicoCampus ConkalConkalYucatán97345Mexico Institute of Agricultural Sciences Universidad Autonoma de Baja CaliforniaEjido Nuevo LeonMexicaliBaja California21705Mexico Instituto de Ingeniería Universidad Autónoma de Baja CaliforniaMexicaliBaja California21100Mexico Division of Postgraduate Studies and Research Tecnologico Nacional de MexicoCampus Tuxtla GutierrezTuxtla GutierrezChiapas29050Mexico

This work was carried out to evaluate the insecticidal effect of mono,bi and trimetallic nanoparticles(NPs)from leaf extract of habanero pepper(Capsicum chinense Jacq.)on the red flour beetle(Tribolium castaneum herbst.)and cotton mealybug(Phenacoccus solenopsis Tinsley).The results showed that Cu NPs,Cu/Mn NPs and Zn/Cu NPs had high insecticidal effect against ***(63%-80% mortality after 96 h).The Cu NPs and Zn/Cu NPs showed also insecticidal effect against ***,but to a lesser extent(20%–28% after 96 h).With regards to the physicochemical characterization,Cu NPs had a zeta potential of 21.1 mV,whereas Cu/Mn NPs and Zn/Cu NPs exhibited zeta potentials of 200 *** polydispersity index(PDI)values for Cu NPs,Cu/Mn NPs,and Zn/Cu NPs were 10.1,29.16,and 14.34,*** TF-IR spectra of the NPs varied from 600 to 4000 cm−*** EDX weight percentages showed the presence of Cu(0.29%–2.4%),Mn(1.4%),and Zn(2.6%)in Cu/Mn NPs and Zn/Cu NPs,respectively.

关键词： Phytonanoparticles botanical insecticide pest control agronanotechnology

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Toxicological and histopathological effects of Dennettia tripetala seed used as grain protectant,food,and medicine

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Food Quality and Safety 2017年第3期1卷 211-219页

作者： Luke Chinaru Nwosu Chris Olukayode Adedire Emmanuel Oludele Ogunwolu Michael Olufemi Ashamo Food Technology Programme Department of BiologyFederal University of TechnologyAkureOndo State and Department of Crop and Environmental Protection University of AgricultureMakurdiBenue StateNigeria Department of Crop and Soil Science Faculty of AgricultureUniversity of Port HarcourtP.M.B.5323Port HarcourtRivers StateNigeria

The study revealed the safety of Dennettia tripetala seed on man and the *** male rats weighing 0.158-0.168 kg housed in standard cages with free access to food and water were used for the *** median lethal dose(LD50)was estimated using revised up and down *** LD50 for *** seed extract was 5785 mg/kg and this evoked paralysis in rats for 4 days coupled with discharge from the eyes and eventual *** least weight gain by the animals administered 75%seed powder of ***(4338.75 mg/kg)was an index of high powder concentration,whereas the weight loss experienced by group V animals is strongly attributed to chemical assault by permethrin designated as a standard *** high values of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and urea in the groups administered 75%permethrin powder(4338.75 mg/kg)and 75%*** seed powder is an index of liver and kidney injury and *** presence of normal serum levels of ALT,AST,alkaline phosphatase,and creatinine;normal liver and kidney structures;and normal weight gains in the animal groups fed basal diet(control)and basal diet plus 25%*** is a strong indication that 25%*** seed powder(1446.25 mg/kg)supplementation is not toxic to the liver and kidney and therefore supports normal organ *** LD50 recorded strongly indicates that *** has a moderately high safety *** of less than 50%(2892.5 mg/kg)is recommended in the safe use of the plant material as grain protectant,food,and *** botanical insecticide,***,is safer than the conventional synthetic insecticide,permethrin,on account of the latter showing evidence of kidney damage.

关键词： Safety botanical insecticide permethrin supplementation kidney damage

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