Toxicological and histopathological effects of Dennettia tripetala seed used as grain protectant,food,and medicine

作     者：Luke Chinaru Nwosu Chris Olukayode Adedire Emmanuel Oludele Ogunwolu Michael Olufemi Ashamo 

作者机构：Food Technology ProgrammeDepartment of BiologyFederal University of TechnologyAkureOndo State and Department of Crop and Environmental ProtectionUniversity of AgricultureMakurdiBenue StateNigeria Department of Crop and Soil ScienceFaculty of AgricultureUniversity of Port HarcourtP.M.B.5323Port HarcourtRivers StateNigeria 

出 版 物：《Food Quality and Safety》 (食品品质与安全研究（英文版）)

年 卷 期：2017年第1卷第3期

页      面：211-219页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Safety botanical insecticide permethrin supplementation kidney damage 

摘      要：The study revealed the safety of Dennettia tripetala seed on man and the *** male rats weighing 0.158-0.168 kg housed in standard cages with free access to food and water were used for the *** median lethal dose(LD50)was estimated using revised up and down *** LD50 for *** seed extract was 5785 mg/kg and this evoked paralysis in rats for 4 days coupled with discharge from the eyes and eventual *** least weight gain by the animals administered 75%seed powder of ***(4338.75 mg/kg)was an index of high powder concentration,whereas the weight loss experienced by group V animals is strongly attributed to chemical assault by permethrin designated as a standard *** high values of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and urea in the groups administered 75%permethrin powder(4338.75 mg/kg)and 75%*** seed powder is an index of liver and kidney injury and *** presence of normal serum levels of ALT,AST,alkaline phosphatase,and creatinine;normal liver and kidney structures;and normal weight gains in the animal groups fed basal diet(control)and basal diet plus 25%*** is a strong indication that 25%*** seed powder(1446.25 mg/kg)supplementation is not toxic to the liver and kidney and therefore supports normal organ *** LD50 recorded strongly indicates that *** has a moderately high safety *** of less than 50%(2892.5 mg/kg)is recommended in the safe use of the plant material as grain protectant,food,and *** botanical insecticide,***,is safer than the conventional synthetic insecticide,permethrin,on account of the latter showing evidence of kidney damage.