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blood glucose response after oral lactulose intake in type 2 diabetic individuals

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World Journal of Diabetes 2021年第6期12卷 893-907页

作者： Thomas R Pieber Eva Svehlikova Ines Mursic Tamara Esterl Manfred Wargenau Tina Sartorius Lioba Pauly Susann Schwejda-Guettes Annalena Neumann Valentin Faerber John Friedrich Stover Barbara Gaigg Angelika Kuchinka-Koch Division of Endocrinology and Diabetology Department of Internal MedicineMedical University of GrazGraz 8036Austria Department of Statistic M.A.R.C.O.GmbH&Co.KGInstitute for Clinical Research and StatisticsDüsseldorf 40211Germany Department of Nutritional CRO BioTeSys GmbHEsslingen 73728Germany Department of Medical&Clinical Affairs Market Access&Education Business Unit Enteral NutritionBad Homburg 61352Germany Department of Medical Clinical&Regulatory AffairsBusiness Unit Parenteral NutritionKeto-Analogues and Standard I.V.FluidsFresenius Kabi Deutschland GmbHBad Homburg 61352Germany Department of Consultancy Stover-SolutionsZurich 8006Switzerland Market Unit Lactulose Fresenius Kabi Austria GmbHLinz 4020Austria

BACKGROUND Lactulose is approved for the symptomatic treatment of constipation,a gastrointestinal(GI)complication common in individuals with *** products contain carbohydrate impurities(e.g.,lactose,fructose,galactose),which occur during the lactulose manufacturing *** impurities may affect the blood glucose levels of individuals with type 2 diabetes mellitus(T2DM)using lactulose for the treatment of mild constipation.A previous study in healthy subjects revealed no increase in blood glucose levels after oral lactulose ***,it is still unclear whether the intake of lactulose increases blood glucose levels in individuals with *** To evaluate the blood glucose profile after oral lactulose intake in mildly constipated,non-insulin-dependent subjects with T2DM in an outpatient *** This prospective,double-blind,randomized,controlled,single-center trial was conducted at the Clinical Research Center at the Medical University of Graz,Austria,in 24 adult Caucasian mildly constipated,non-insulin-dependent subjects with *** subjects were randomized and assigned to one of six treatment sequences,each consisting of four treatments stratified by sex using an incomplete block *** received a single dose of 20 g or 30 g lactulose(crystal and liquid formulation),water as negative control or 30 g glucose as positive *** blood glucose concentrations were measured over a period of 180 min post *** primary endpoint was the baseline-corrected area under the curve of blood glucose concentrations over the complete assessment period[AUC_(baseline_c(0-180 min))].Quantitative comparisons were performed for both lactulose doses and formulations vs water for the equal lactulose dose vs glucose,as well as for liquid lactulose vs crystal *** parameters included GI tolerability,which was assessed at 180 min and 24 h post dose,and adverse events occurring up to 24 h post *** 24 randomized

关键词： Lactulose Constipation blood glucose Type 2 diabetes mellitus Laxative Sugar substitute

Association of serum levels of perfluoroalkyl substances with gestational diabetes mellitus and postpartum blood glucose

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Journal of Environmental Sciences 2018年第7期30卷 5-11页

作者： Yuxin Wang Lei Zhang Yue Teng Jiayu Zhang Lin Yang Jingguang Li Jianqiang Lai Yunfeng Zhao Yongning Wu The Key Laboratory of Food Safety Risk Assessment Ministry of Health (CFSA) China National Center for Food Safety Risk AssessmentBeijing 100021 China Haidian Maternal and Child Hygiene Hospital Beijing 100080 China College of Literature Science and Arts University of Michigan Ann Arbor MI48104 USA National Institute for Nutrition and Health Chinese Center for Disease Control and Prevention Beijing 100050 China

This study was conducted to examine the association of perfluoroalkyl substance（PFAS）exposure with gestational diabetes mellitus（GDM） risk and postpartum fasting blood *** used a 1：2 matched case–control study with 84 GDM subjects and 168 healthy pregnant women from Beijing, China. The maternal blood was collected at 1–2 days before delivery, and eight linear isomers and fourteen branched isomers were determined in maternal *** regression analyses were performed to evaluate the associations after adjusting for potential confounders. The median of the sum of levels of total PFASs was 4.24 ng/m L with a interquartile range（IQR） of 2.82–6.54 ng/m L. Although maternal PFAS exposure was not associated with risk of GDM, significant positive associations were observed between evaluated exposure to specific PFAS congeners and increasing blood glucose. The odds ratio（ORs） of the highest category of postpartum fasting blood glucose for perfluoro-1-metylheptylsulfonat（1 m-PFOS）, perfluoro-3/4-metylheptylsulfonat（3 m＋4 m-PFOS）, perfluoro-5-metylheptylsulfonat（5 m-PFOS）, and perfluorohexane sulfonate（PFHx S） were 2.03（95% CI： 1.09–3.77）, 1.93（95% CI：1.04–3.58）, 2.48（95% CI： 1.33–4.65）, and 2.26（95% CI： 1.21–4.21）, respectively, suggesting negative effects of maternal exposure to specific PFAS compounds on glucose metabolism.

关键词： Perfluoroalkyl substances Gestational diabetes mellitus blood glucose

Abnormal blood glucose Concentration on Degradation Behavior of AZ31 Magnesium Alloy

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Chemical Research in Chinese Universities 2020年第6期36卷 1217-1226页

作者： LI Zhihui GUO Xiaotong ZHANG Yaning LIU Guangzhou ZHANG Shuyong School of Chemistry and Chemical Engineering Shandong UniversityJinan 250100P.R.China Institute of Marine Science and Technology Shandong UniversityQingdao 266237 P.R.China

In order to evaluate the effect of blood glucose concentration on the reliability of AZ31 magnesium alloy medical implant,the corrosion of AZ31 alloy was studied in a simulated physiological saline *** is found that when the glucose concentration is in the normal range of ca.1g/L,the corrosion of AZ31 alloy can be inhibited However,when the glucose concentration becomes higher like that of diabetic patients,the degradation of AZ31 alloy is significantly ***,for diabetic patients,the change in glucose concentration must be taken into consideration in order to ensure the reliability ofAZ31 medical implants.

关键词： Medical implant material AZ31 magnesium alloy Degradation blood glucose Hyperglycemia

Solution of Modified Bergman Minimal blood glucose-Insulin Model Using Caputo-Fabrizio Fractional Derivative

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Computer Modeling in Engineering & Sciences 2021年第9期128卷 1247-1263页

作者： Ravi Shanker Dubey Dumitru Baleanu Manvendra Narayan Mishra Pranay Goswami Department of Mathematics AMITY School of Applied ScienceAMITY University RajasthanJaipur302022India Department of Mathematics and Computer Sciences Cankaya UniversityBalgat06530Turkey Institute of Space Sciences Magurele-BucharestR76900Romania School of Liberal Studies Dr.B.R.Ambedkar University DelhiDelhi110006India

Diabetes is a burning issue in the whole *** is the imbalance between body glucose and *** study of this imbalance is very much needed from a research point of *** this reason,Bergman gave an important model named-Bergman *** the present work,using Caputo-Fabrizio(CF)fractional derivative,we generalize Bergman’s minimal blood glucose-insulin ***,we modify the old model by including one more component known as diet D(t),which is also essential for the blood glucose *** solve the modified modelwith the help of Sumudu transformand fixed-point iteration ***,using the fixed point theorem,we examine the existence and uniqueness of the results along with their numerical and graphical ***,the comparison between the values of parameters obtained by calculating different values of t with experimental data is also ***,we draw the graphs of G(t),X(t),I(t),andD(t)for different values ofτ.It is also clear from the obtained results and their graphical representation that the obtained results of modified Bergman’s minimal model are better than Bergman’s model.

关键词： Bergman minimal model blood glucose Caputo-Fabrizio fractional derivative uniqueness and existence fractional calculus

Power spectral density-based nearinfrared sub-band detection for noninvasive blood glucose prediction in both in-vitro and in-vivo studies

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Journal of Innovative Optical Health Sciences 2018年第6期11卷 43-54页

作者： Ibrahim Akkaya Izmir Biomedicine and Genome Center(iBG)Balcova Izmir 35340Turkey Erman Selim Mert Altintas and Mehmet Engin Electrical Electronics Engineering Department Ege UniversityBornovaIzmir 35040Turkey

Diabetes is a widespread and serious disease and noninvasive measurement has been in high *** address this problem,a power spectral density-based method was offered for determining glucose sensitive sub-bands in the nearinfrared(NIR)*** experiments were conducted using phantoms of different optical properties in-vitro *** optical bands 1200–1300 nm and 2100–2200 nm were found feasible for measuring blood *** that,a photoplethysmography(PPG)-based low cost and portable optical system was *** has six di®erent NIR wavelength LEDs for illumination and an InGaAs photodiode for *** density values were calculated through the system and used as independent variables for multiple linear regression *** results of blood glucose levels for 24 known healthy subjects showed that the optical system prediction was nearly 80%in the A zone and 20%in the B zone according to the Clarke Error Grid *** was shown that a promising easyuse,continuous,and compact optical system had been designed.

关键词： Noninvasive blood glucose nearinfrared led photoplethysmography power density

Maternal exposure to specific perfluoroalkyl substances is associated with increasing blood glucose in pregnant women

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Journal of Environmental Sciences 2018年第7期30卷 1-2页

作者： Jagdeesh S.Uppal Qi Zheng X.Chris Le Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and Dentistry University of Alberta Key Laboratory of Optoelectronic Chemical Materials and Devices Ministry of Education Institute of Environment and HealthJianghan University

Imagine if a group of toxic substances that increase oxidative stress and disrupt glucose and lipid metabolism have been broadly used worldwide for applications such as repellent,food packaging,and non-stick frying pa... 详细信息

关键词： perfluoroalkyl and polyfluoroalkyl substances PFAS PFOS gestational diabetes mellitus blood glucose

Cognitive decline is related to high blood glucose levels in older Chinese adults with the ApoE ε3/ε3 genotype

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Translational Neurodegeneration 2019年第1期8卷 134-140页

作者： Qi Qiu Xiang Lin Lin Sun Min-jie Zhu Tao Wang Jing-hua Wang Guan-jun Li Shi-fu Xiao Xia Li Department of Psychogeriatrics Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineSouth WanPing Road 600Shanghai 200030China

Background:Few studies have investigated the effects of blood glucose(BG)on cognitive function in communitydwelling elderly individuals carrying the apolipoprotein E(APOE)ε3 ***:To explore the effect of high BG levels on cognitive function in APOEε3-carrying,non-demented,community-dwelling older adults,as compared to their counterparts carrying the APOEε4 or APOEε2 ***:Within the China Longitudinal Ageing Study,we recruited 282 elderly adults without *** collected included demographic information;psychological measures;laboratory test results,including BG and plasma lipid levels;and APOE *** divided the participants into APOEε2(ε2/ε2,ε2/ε3),ε3(ε3/ε3),andε4(ε3/ε4,ε4/ε4)*** correlation analyses and multivariate linear regression analyses were utilized to compare the cognitive function and laboratory data between the APOE *** matter hyperintensity(WMH)was measured on magnetic resonance images in 77 ***:With adjustment for age,sex,education,and diabetes,higher BG in non-demented community-dwelling older adults was associated with cognitive decline in immediate memory and executive *** the APOEε3 group,elevated BG was associated with cognitive decline in immediate memory,executive function,and perceptual *** the APOEε4 group,higher BG was also correlated with a decline in abstract *** was a trend for association between higher BG and more severe ***:Worse cognitive function was correlated withApoEε3/ε3 genotype carriers with higher BG in community-dwelling older adults.

关键词： Apolipoproteins E Cognition blood glucose Aged White matter Community-based

Intraoperative blood glucose Levels and Postoperative Acute Kidney Injury in Pediatric Patients Having Congenital Heart Surgery under Cardiopulmonary Bypass

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Congenital Heart Disease 2023年第4期18卷 475-488页

作者： Dongyun Bie Hongbai Wang Chaobin Zhang Chunrong Wang Yuan Jia Su Yuan Sheng Shi Jiangshan Huang Jianhui Wang Fuxia Yan Department of Anesthesiology Fuwai HospitalNational Centre for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Anesthesiology Fuwai HospitalChinese Academy of Medical SciencesShenzhenChina Department of Anesthesiology Peking Union Medical College HospitalBeijingChina

Purpose:This study sought to explore the effect of intraoperative mean blood glucose levels and variability on postoperative acute kidney injury(AKI)in children undergoing congenital cardiac ***:We conducted a prospective nested case-control study in children(ageblood glucose variables and ***:688 consecutively approached patients were included in the final *** multivariate analysis,intra-CPB(adjusted odds ratio[OR]0.802;95%confidence interval[CI],0.706 to 0.912;p=0.001)and post-CPB(adjusted OR 0.830;95%CI,0.744 to 0.925;p=0.001)blood glucose levels were associated with postoperative *** were no significant differences in pre-CPB blood glucose(adjusted OR 0.926;95%CI,0.759 to 1.129;p=0.446)or intraoperative glycemic fluctuations(adjusted OR 0.905;95%CI,0.723 to 1.132;p=0.382)between AKI and Non-AKI *** based on matched cases and controls were consistent with those from the unmatched ***:Higher intraoperative blood glucose levels during and after CPB were protective factors against postoperative AKI in pediatric patients after congenital heart surgery.

关键词： blood glucose children congenital heart surgery cardiopulmonary bypass acute kidney injury

Effect of dates on blood glucose and lipid profile among patients with type 2 diabetes

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World Journal of Diabetes 2024年第6期15卷 1079-1085页

作者： Hyder Osman Mirghani Internal Medicine University of TabukSaudi ArabiaTabuk 51941TabukSaudi Arabia

Poor fruit and vegetable consumption is one of the 10 major risk factors for *** is a misconception regarding the consumption of dates among patients with *** manuscript assessed the effects of date consumption on fasting and postprandial blood glucose,glycated hemoglobin,total cholesterol,triglycerides,low-density lipoproteins,high-density lipoproteins,and microbial *** literature databases were searched for relevant *** the 595 studies retrieved,24 assessed the effects of dates on glycemic control and ***,the evidence suggests that dates have a lowering effect on blood *** reduce total cholesterol and triglyceride levels and increase high-density lipoprotein *** also promote the abundance of beneficial gut ***,patients with diabetes and dyslipidemia can consume dates to reduce their blood glucose,cholesterol,and triglycerides.

关键词： Dates Lipid profile blood glucose Diabetes mellitus Microbial contamination