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Printed Biosensors for the Detection of Alzheimer’s Disease Based on blood biomarkers

Journal of Analysis and Testing 2024年第2期8卷 133-142页

作者： Yu Zeng Zhen Huang Yibiao Liu Tailin Xu Longgang Central Hospital of Shenzhen Shenzhen518116China School of Biomedical Engineering Shenzhen UniversityShenzhen518060China

Alzheimer’s disease(AD)is a chronic neurodegenerative disorder,and early diagnosis plays a crucial role in its prevention and *** recent years,blood-based biomarkers for early AD diagnosis have gained attention due to their non-invasiveness and minimal adverse reactions,which make them an attractive *** the onset of the COVID-19 pandemic,visiting large medical examination centers for blood tests has become increasingly *** trend is shifting towards community or home-based sampling,which relies on the development and application of portable,miniaturized,and highly sensitive *** the various sensors used for detecting blood biomarkers in AD,printed sensors demonstrate great potential in AD blood biomarker detection due to their ease of miniaturization,scalability for mass production,and compatibility with various detection *** this review,we focus on discussing the application of printed sensors in the analysis of blood biomarkers for *** also explore the challenges faced by printed sensors in early diagnosis based on AD blood biomarkers and propose potential solutions to address these challenges.

关键词： Printed biosensors Alzheimer’s disease blood biomarkers Printing technology

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The Association Between Subjective Wellness Symptoms and blood Biomarker Data in English Premier League Footballers

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Journal of Science in Sport and Exercise 2023年第4期5卷 340-347页

作者： Marc Cleary Fearghal McHugh Kyle F.Paradis Galway-May Institute of Technology GalwayIreland Ulster University BelfastNorthern Ireland

The present study investigates the association between subjective wellness symptoms,and categorical point-of-care(POC)blood biomarkers of the free oxygen radical test(FORT),and systemic inflammation through high sensitivity C-reactive protein(Hs-CRP),in English Premier League *** from 38 male professional elite athletes(Mean Age=25.8,SD=4.4)from the English Premier League were included in the study,with a total of 674 individual testing records collected over an entire Premier League season.A player wellness questionnaire,along with fasted and rested point-of-care blood biomarker testing were collected weekly across the *** wellness questionnaire collected subjective symptoms of illness and fatigue,while FORT and Hs-CRP were assessed through point-of-care analysis to highlight periods of excessive hydroperoxide production and systemic *** a chi square goodness of fit model,results showed that there was a significant association between the frequency of symptoms logged and categorical POC blood biomarker data of FORT and HsCRP(P<0.01).Of the records demonstrating normal levels of Hs-CRP and FORT concentrations,27%logged symptoms with an average of 1.5 symptoms reported per answered ***,excessive biomarker values demonstrated 55%of records having symptoms logged,averaging 2.4 symptoms reported per record.

关键词： athlete wellness blood biomarkers premier league football elite athletes high performance sport

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Lower serum expression of miR-181c-5p is associated with increased plasma levels of amyloid-beta 1-40 and cerebral vulnerability in normal aging

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Translational Neurodegeneration 2019年第1期8卷 423-432页

作者： Marta Manzano-Crespo Mercedes Atienza Jose L.Cantero Laboratory of Functional Neuroscience Pablo de Olavide UniversityCtra.de Utrera Km 141013 SevilleSpain CIBERNED Network Center for Biomedical Research in Neurodegenerative Diseases28031MadridSpain

Background:Previous studies have shown that expression levels of miR-181c are downregulated by amyloid-β(Aβ)deposition and chronic cerebral hypoperfusion,both factors largely associated with the development of ***,reduced 2-[18F]fluoro-2-deoxy-D-glucose(FDG)-PET brain metabolism and volume loss of regions of the medial temporal lobe have been generally recognized as hallmarks of *** on this evidence,we have here investigated potential associations between serum levels of miR-181c-5p and these AD signatures in asymptomatic elderly ***:Ninety-five normal elderly subjects underwent clinical,cognitive,structural MRI,and FDG-PET *** expression levels of miR-181c-5p and plasma Aβ concentrations were further analyzed in this *** analyses were performed to assess associations between serum miR-181c-5p levels and cognitive functioning,plasma Aβ,structural and metabolic brain ***:Decreased serum expression of miR-181c-5p was associated with increased plasma levels of Aβ1–40,deficits in cortical glucose metabolism,and volume reduction of the entorhinal *** significant associations were found between lower miR-181c-5p levels and cognitive deficits or cortical ***:These findings suggest that deregulation of serum miR-181c-5p may indicate cerebral vulnerability in late life.

关键词： Aging Alzheimer’s disease blood biomarkers microRNAs Amyloid-beta FDG-PET Entorhinal cortex

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