检索结果-南通市图书馆

Chinese Journal of Polymer Science 2003年第1期21卷 45-50页

作者：林思聪 Research Center on Surface and Interface Chemistry Engineering and Technology. Nanjing University Nanjing 210093 China

A new phosphorylcholine, (6-hydroxy) hexyl-2-(trimethylammonio) ethyl phosphate (HTEP), was synthesized andcharasterized. Segmented polyurethane (SPU) containing phosphorylcholine structure was synthesized based ondiphenylmethane diisocyanate (MDI), soft segment polytetramethylene glycol (PTMG) and HTEP, with 1,4-butanediol (BD)as a chain extender. The existence of phosphorylcholine structure on the surface of SPU was revealed by attenuated totalreflectance Fourier transform infrard spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS) and water contactangle measurements. The blood compatibilities of the polymers were evaluated by hemolytic testing and a platelet-richplasma (PRP) adhesion experiment, which was viewed by scanning electron microscopy (SEM) with polyurethane as areference. The novel segmented polyurethane containing phosphorylcholine structure showed improved blood compatibility.

关键词： Platelet adhesion Phosphorylcholine Zwitterionic structure blood compatibility Segmented polyurethane

blood compatibility of Nano-Hydroxyapatite Dispersed Using Various Agents

在线全文

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2010年第4期15卷 350-354页

作者： YANG Lijian1, JIN Huafang2, YUAN Lin2 1. Hospital, Wuhan University of Technology, Wuhan 430070, Hubei, China 2. Biology Center,Wuhan University of Technology, Wuhan 430070, Hubei, China Hospital Wuhan University of Technology Wuhan Hubei China Biology Center Wuhan University of Technology Wuhan Hubei China

Nano-hydroxyapatite (nHAP),dispersed with three kinds of dispersants (heparin sodium,polyacrylic sodium and wa-ter),reacted with red blood cell,Bel-7402 tumor cell,to compare their dispersing efficiency against nHAP from one another. The blood compatibility of nHAP is also determined by blood solubil-ity experiment so that the capability of different dispersant dis-persing against nHAP of different concentration and the relation between nHAP and blood compatibility have been determined. The inhibiting function of Bel-7402 against tumor cells is deter-mined with the MTT staining method. The study result shows that heparin sodium has the best dispersing efficiency for nHAP with-out the phenomenon of hemolysis.

关键词： nano-hydroxyapatite heparin sodium polyacrylic sodium blood compatibility

LARGELY IMPROVED blood compatibility OF POLYURETHANE BY BLENDING WITH FLUORINATED PHOSPHATIDYLCHOLINE POLYURETHANE

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2008年第2期26卷 203-211页

作者：傅强 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan University

The improvement of biocompatibility of polyurethanes was *** results demonstrate that the blood compatibility of polyurethanes can be further improved by just simply mixing with the fluorinated phosphatidylcholine poly(carbonate urethane)s(FPCPCUs).The solution blending was done by mixing poly(ether urethane)(PEU)with FPCPCU in different *** increased blood compatibility of the blend films was observed with the increase of FPCPCU content,and when FPCPCU content reached to 40 wt%(40F...

关键词： Fluorinated phosphatidylcholine poly(carbonate urethane)s blood compatibility Migration and segregation.

In vitro blood compatibility of Polyethylene Terephthalate with Covalently Bounded Hirudin on Surface

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2011年第5期26卷 950-954页

作者：李方 School of Petroleum Engineering Southwest Petroleum University Lab of Surface Modification of Artificial Organs of Sichuan Key Laboratory of Advanced Technologies of MaterialsMinistry of EducationSouthwest Jiaotong University

Polyethylene terephthalate （PET,Dacron） was modified by surface immobilization of hirudin with glutaraldehyde（GA） as coupling reagent to improve the blood ***-immobilized PETs were characterized by X-ray photoelectron spectroscopy （XPS） and contact angle *** blood compatibility of the PETs was evaluated by platelet adhesion evaluation and fibrinogen conformational change measurements in *** results showed the decrease of platelet adhesion and activation on hirudin-immobilized PET with increasing of glutaraldehyde *** experiment showed that fibrinogen adherence and conformational changes of PET-HRD were less than those of untreated PET,which made the materials difficult to form *** proper reason of blood compatibility improvement was low interface tension between hirudin-immobilized PETs and blood,as well as blood proteins,and low ratio of dispersive/polar component of the surface energy（γsd/γsp） and high hydrophilicity.

关键词： hirudin blood compatibility poly(ethylene terephthalate) (PET) interface tension surface energy

Surface Characterization and in Vitro blood compatibility of Poly (Ethylene Terephthalate) Immobilized with Hirudin

在线全文

学校读者我要写书评

暂无评论

Plasma Science and Technology 2010年第2期12卷 235-239页

作者：李方王进孙鸿黄楠 Key Laboratory of Advanced Technologies of Materials (Southwest Jiaotong University) Ministry of Education Southwest Jiaotong University Petroleum Engineering Institute Southwest Petroleum University

Poly （ethylene terephthalate）（dacron, PET） films were exposed under argon plasma glow discharge with different glows and induced polymerization of acrylic acid（AA） in order to in- troduce carboxylic acid group onto PET （PET-AA） assisted by ultraviolet radiation（UV）. Hirudin- immobilized PET （PET-HRD） films were prepared by the grafting of PET-AA, followed by chem- ical reaction with hirudin. The surface structure of the treated PET was determined by X-ray photoelectron spectroscopy （XPS）. The wettability, surface free energy, and interface free energy of the films were investigated by contact angle measurement. The blood compatibility of the films was assessed by platelet-adhesion test and fibrinogen conformational change measurements to eval- uate the viability of the materials in biomedical engineering. Measurement by scanning electron microscopy （SEM） revealed that the amounts of adhered, aggregated and morphologically changed platelets were reduced on the hirudin-immobilized PET films. Enzyme-linked-immunoassay mea- surements that disclosed fibrinogen conformational changes showed results consistent with the platelets＇ behavior.

关键词： hirudin blood compatibility poly (ethylene terephthalate) interface energy surface energy

Microwave-assisted Immobilization of Heparin onto Polyurethane Surface for Improving blood compatibility

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2014年第5期29卷 1071-1077页

作者：邱炳崧 MAI Weizhong 曾戎 TU Mei ZHAO Jianhao ZHA Zhengang Department of Materials Science and Engineering College of Science and Engineering Jinan University Guangzhou Overseas Chinese Hospital the First Affiliated Hospital of Jinan University

Heparin was covalently immobilized onto polyurethane surface via a PEG spacer by a microwave-assisted approach to improve blood compatibility. Firstly, amino-terminated poly（ethylene glycol）（APEG） was rapidly grafted onto PU surface within 20 rain by a two-step method involving microwave-assisted MDI-functionalization and subsequent microwave-assisted APEG coupling. Then, heparin was eovalently immobilized through an amide linkage by the direct coupling of the carboxylic acid of heparin with the amino group of APEG on PU surface using carbodiimide coupling reaction. The surface structure and properties were characterized by X-ray photoelectron spectroscopy （XPS）, atomic force microscopy （AFM） and water contact angle measurements. The results revealed that hepadn-immobilized PU surface had slightly increased roughness and significantly improved hydrophilicity in comparison to the original PU surface. The anticoagulant activity of films was evaluated by whole blood clotting time （CT） and prothrombin time （PT）. Complement activation was assessed by detecting complement fragment 3a concentrations of serum exposed to the films. The results revealed that the microwave-assisted heparin-immobilized PU films had excellent antithrombogenicity and suppressed complement activation, indicating improved blood compatibility.

关键词： surface modification microwave irradiation heparin polyurethane blood compatibility

Preparation and blood compatibility of Oxidized-chitosan Films

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2005年第7期16卷 991-994页

作者： YueDongYANG JiuGaoYU YongGuoZHOU PeiGuoLI DepartrnentofChemistry HebeiNormalUniversityofScience＆TechnologyChangli066600／／DepartmentofChemistrySchoolofScienceTianjinUniversityTianjin300072 DepartmentofChemistry SchoolofScienceTianjinUniversityTianjin300072 DepartmentofChemistry HebeiNormalUniversityofScience＆TechnologyChangli066600

Chitosan membrane was modified by the selective oxidization of chitosan molecules on its surface with NO2 gas. FTIR spectra indicated there were plenty of –COOH and –COO- groups on the modified membrane surface. The SEM study showed the modified membrane surface was rough rather than smooth as chitosan membrane. All antithrombosis test, hemolysis test and blood cell morphology observation with SEM revealed that modified chitosan membranes have superior blood compatibility to chitosan.

关键词： Chitosan blood compatibility modified chitosan membrane nitrogen dioxide.

Improvement of HydrophUicity and blood compatibility on Polyethersulfone Membrane by Blending Sulfonated Polyethersulfone

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2009年第2期17卷 324-329页

作者：王海涛杨刘赵学辉于湉杜启云 The Key Lab of Hollow Fiber Membrane Materials and Membrane Process of Ministry of Education Tianjin Polytechnic University Tianjin 300160 China Department of Bio-medical Engineering Tianjin Polytechnic University Tianjin 300160 China

Polyethersulfone(PES) is widely used as biomaterials due to its thermal stability,mechanical strength,and chemical ***,their blood compatibility is still not adequate for hemodialysis and blood *** this study,the sulfonated polyethersulfone(SPES) was synthesized through an electrophilic substitution reaction,and PES/SPES blending membranes were *** characterization of the SPES was studied by *** water adsorption and water contact angle experiments show that the hydrophilicity of PES/SPES blend membrane was improved as for the sulfonate group existing in the ***,PES/SPES blend membrane could effectively reduce bovine serum albumin adsorption and prolong the blood coagulation time compared with the PES membrane,thereby improving blood compatibility.

关键词： sulfonated polyethersulfone polyethersulfone hydrophilicity blood compatibility blending

Study on blood compatibility of Carbon-Nitride Film Synthesized by Ion Beam Enhanced Deposition

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Transportation 1997年第2期14卷 79-84页

In this paper, blood compatibility of carbonnitride film synthesized by ion beam enhanced deposition is studied. Clotting time measurement, platelet adhesion test and surface energy determination were performed to evaluate the interaction between blood and material. The results show that carbonnitride film has better blood compatibility than titanium, and may be promising in biomaterial filed.

关键词： biomaterials carbonnitride film blood compatibility ion beam enhanced deposition

Preparation and Adsorption Properties of PAM Based Adsorbents for Plasma Lipoproteins

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2004年第4期15卷 449-452页

作者： HaiTaoLI ZhiYUAN XinFuCHEN BinLIU BinSHEN BingLinHE TheStateKeyLaboratoryofFunctionalPolymerMaterialsforAdsorptionandSeparation InstituteofPolymerChemistryNankaiUniversityTianjin300071 TianjinMedicalCollege Tianjin300052

Crosslinked macroporous polyacrylamide (PAM) was prepared with inverse phase suspension polymerization technique. After treatment with hydrazine, the polymer was functionalized with chloroacetic acid, trifluoroacetic acid diethylenetriaminepentaacetic acid (DEPAA), and maleic acid, respectively, and PAM based adsorbents bearing carboxyl functional groups for low density lipoprotein (LDL) apheresis use were obtained. The blood compatibility and the adsorption properties for plasma lipoproteins of PAM based adsorbents were investigated.

关键词： Macroporous polyacrylamide blood compatibility adsorption LDL apheresis.