Blood Compatibility of Nano-Hydroxyapatite Dispersed Using Various Agents

作     者：YANG Lijian1, JIN Huafang2, YUAN Lin2 1. Hospital, Wuhan University of Technology, Wuhan 430070, Hubei, China 2. Biology Center,Wuhan University of Technology, Wuhan 430070, Hubei, China 

作者机构：Hospital Wuhan University of Technology Wuhan Hubei China Biology Center Wuhan University of Technology Wuhan Hubei China 

出 版 物：《Wuhan University Journal of Natural Sciences》 (武汉大学学报（自然科学英文版）)

年 卷 期：2010年第15卷第4期

页      面：350-354页

学科分类：07[理学] 08[工学] 

基　　金：Supported by the National Basic Research Program of China(973 Program) (2005CB623905) 

主　　题：nano-hydroxyapatite heparin sodium polyacrylic sodium blood compatibility 

摘      要：Nano-hydroxyapatite (nHAP),dispersed with three kinds of dispersants (heparin sodium,polyacrylic sodium and wa-ter),reacted with red blood cell,Bel-7402 tumor cell,to compare their dispersing efficiency against nHAP from one another. The blood compatibility of nHAP is also determined by blood solubil-ity experiment so that the capability of different dispersant dis-persing against nHAP of different concentration and the relation between nHAP and blood compatibility have been determined. The inhibiting function of Bel-7402 against tumor cells is deter-mined with the MTT staining method. The study result shows that heparin sodium has the best dispersing efficiency for nHAP with-out the phenomenon of hemolysis.