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Effects of 45S5 bioglass on surface properties of dental enamel subjected to 35% hydrogen peroxide

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International Journal of Oral Science 2013年第2期5卷 103-110页

作者： Meng Deng Hai-Lin Wen Xiao-Li Dong Feng Li Xin Xu Hong Li Ji-Yao Li Xue-Dong Zhou State Key Laboratory of Oral Diseases Department of Endodontics and Operative DentistryWest China Hospital of StomatologySichuan University Department of Restorative Dentistry Hangzhou Dental HospitalCollege of StomatologyZhejiang Chinese Medical University

Tooth bleaching agents may weaken the tooth structure. Therefore, it is important to minimize any risks of tooth hard tissue damage caused by bleaching agents. The aim of this study was to evaluate the effects of applying 45S5 bioglass （BG） before, after, and during 35% hydrogen peroxide （HP） bleaching on whitening efficacy, physicochemical properties and microstructures of bovine enamel. Seventy-two bovine enamel blocks were prepared and randomly divided into six groups： distilled deionized water （DDW）, BG, HP, BG before HP, BG after HP and BG during HP. Colorimetric and microhardness tests were performed before and after the treatment procedure. Representative specimens from each group were selected for morphology investigation after the final tests. A significant color change was observed in group HP, BG before HP, BG after HP and BG during HP. The microhardness loss was in the following order： group HP〉 BG before HP, BG after HP〉 BG during HP〉DDW, BG. The most obvious morphological alteration of was observed on enamel surfaces in group HP, and a slight morphological alteration was also detected in group BG before HP and BG after HP. Our findings suggest that the combination use of BG and HP could not impede the tooth whitening efficacy. Using BG during HP brought better protective effect than pre/post-bleaching use of BG, as it could more effectively reduce the mineral loss as well as retain the surface integrity of enamel. BG may serve as a promising biomimetic adjunct for bleaching therapy to prevent/restore the enamel damage induced by bleaching agents.

关键词： bioglass enamel hydrogen peroxide tooth bleaching

Osteostimulation of bioglass

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Chinese Medical Journal 2009年第19期122卷 2386-2389页

作者： HU Yong-cheng ZHONG Ji-pin Chinese Journal of Orthopaedics Tianjin Hospital Tianjin 300211China NovaBone Products LLC Florida 32615 USA

bioglass, with the code name 45S5, contains 45% silica, 24.5% CaO, 24.5% Na2O and 6% P2O5 in weight percent. All of these oxides are mixed together and melted at around 1350℃ to form a homogeneous silica network glass.1 bioglass possesses fast biological response and fast bioactivity, when implanted in living tissue. Since Hench et alI reported over 35 years ago that the bioglass composition could chemically bind to bone,

关键词： bioglass osteogenesis bone substitutes

Modulating degradation of sodium alginate/bioglass hydrogel for improving tissue infiltration and promoting wound healing

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Bioactive Materials 2021年第11期6卷 3692-3704页

作者： Xin Zhang Ying Li Zhijie Ma Dan He Haiyan Li School of Biomedical Engineering Shanghai Jiao Tong University1954 Huashan RoadShanghai200030China Chemical1nd Environmental Engineering School of EngineeringRMIT University124 La Trobe StMelbourneVIC3000Australia

More and more studies have recognized that the nanosized pores of hydrogels are too small for cells to normally grow and newly formed tissue to infiltrate,which impedes tissue ***,hydrogels with macropores and/or controlled degradation attract more and more attention for solving this *** alginate/bioglass(SA/BG)hydrogel,which has been reported to be an injectable and bioactive hydrogel,is also limited to be used as tissue engineering scaffolds due to its nanosized ***,in this study,degradation of SA/BG hydrogel was modulated by grafting deferoxamine(DFO)to *** functionalized grafted DFO-SA(G-DFO-SA)was used to form G-DFO-SA/BG injectable *** vitro degradation experiments proved that,compared to SA/BG hydrogel,G-DFO-SA/BG hydrogel had a faster mass loss and structural *** the hydrogels were implanted subcutaneously,G-DFO-SA/BG hydrogel possessed a faster degradation and better tissue infiltration as compared to SA/BG *** addition,in a rat full-thickness skin defect model,wound healing studies showed that,G-DFO-SA/BG hydrogel significantly accelerated wound healing process by inducing more blood vessels ***,G-DFO-SA/BG hydrogel can promote tissue infiltration and stimulate angiogenesis formation,which suggesting a promising application potential in tissue regeneration.

关键词： Sodium alginate bioglass Hydrogels degradation Tissue infiltration Wound healing

e-PTFE与bioglass结合修复重建下颌骨缺损的实验研究

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山东医科大学学报 2001年第5期39卷 439-441页

作者：王旭霞魏奉才张君徐欣单保忠山东大学口腔医院口腔外科山东大学齐鲁医院口腔科济南市中心医院口腔科

目的 :通过动物实验 ,观察膜引导组织再生术 (MGTR)与生物活性材料结合修复重建下颌骨骨缺损的效果。方法 :手术制备下颌骨标准骨缺损不愈合模型 ,将膨体聚四氟乙烯膜 (e PTFE)与bioglass结合修复下颌骨缺损。结果 :实验组 (e PTFE Biog... 详细信息

目的 :通过动物实验 ,观察膜引导组织再生术 (MGTR)与生物活性材料结合修复重建下颌骨骨缺损的效果。方法 :手术制备下颌骨标准骨缺损不愈合模型 ,将膨体聚四氟乙烯膜 (e PTFE)与bioglass结合修复下颌骨缺损。结果 :实验组 (e PTFE bioglass)与对照组 (e PTFE)在术后各时点 2、4、8、12w新生骨形成量有显著差异 (P bioglass结合修复重建下颌骨骨缺损 ,术后成骨早 ,术后 12w似正常骨质 ,为进一步临床应用提供实验依据。

关键词：膨体聚四氟乙烯膜 bioglass 下颌修复术下颌骨缺损实验研究

Update on the use of 45S5 bioactive glass in the treatment of bone defects in regenerative medicine

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World Journal of Orthopedics 2024年第3期15卷 204-214页

作者： Dayane Maria Braz Nogueira Marcelie Priscila de Oliveira Rosso Daniela Vieira Buchaim Mariana Schutzer Ragghianti Zangrando Rogério Leone Buchaim Department of Prosthodontics and Periodontics Bauru School of DentistryUniversity of São PauloBauru 17012-901Brazil Department of Biological Sciences Bauru School of DentistryUniversity of São PauloBauru 17012-901Brazil Medical School University Center of AdamantinaAdamantina 17800-000Brazil Postgraduate Program in Structural and Functional Interactions in Rehabilitation Postgraduate DepartmentUniversity of MaríliaMarília 17525-902Brazil

Bone regeneration is a critical area in regenerative medicine,particularly in orthopedics,demanding effective biomedical materials for treating bone defects.45S5 bioactive glass(45S5 BG)is a promising material because of its osteoconductive and bioactive *** research in this field continues to advance,keeping up-to-date on the latest and most successful applications of this material is *** achieve this,we conducted a comprehensive search on Pub-Med/MEDLINE,focusing on English articles published in the last *** search used the keywords“bioglass 45S5 AND bone defect”in *** found 27 articles,and after applying the inclusion criteria,we selected 15 studies for detailed *** of these studies compared 45S5 BG with other cement or scaffold *** comparisons demonstrate that the addition of various composites enhances cellular biocompatibility,as evidenced by the cells and their osteogenic ***,the use of 45S5 BG is enhanced by its antimicrobial properties,opening avenues for additional investigations and applications of this biomaterial.

关键词： Biocompatible materials bioglass Bone regeneration

Preparation and Characterization of Porous Calcium Phosphate Bioceramics

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Journal of Materials Science & Technology 2011年第5期27卷 431-436页

作者： Honglian Dai Xinyu Wang Yinchao Han Xin Jiang Shipu Li Biomedical Materials and Engineering Center Wuhan University of Technology Wuhan 430070 China

β-tricalcium phosphate （β-TCP） powder and Na20-CaO-MgO-P205 glass binder were synthesized and mixed, and then the biodegradable porous calcium phosphate ceramics were successfully prepared by foaming and sintering at 850℃. The as-prepared ceramics possess a high porosity with partial three-dimension interconnected macro- and micro-pores. As in vitro experiment testified, the calcium phosphate ceramics （CPCs） has good degradability.

关键词： Calcium phosphate ceramics bioglass Foaming Porous Degradation

Preparation of Ti6Al4V/BG/HA graded coating by electrophoresis deposition in absolute alcohol medium

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中国有色金属学会会刊：英文版 2001年第5期11卷 696-699页

作者：李世普陈晓明韩庆荣许传波武汉理工大学生物材料与工程研究中心湖北武汉 430070

A codeposition of bioglass (BG) and hydroxyapatite (HA) on the substrate Ti6Al4V is realized in a nonaqueous solution system by inducing crystallization of HA on surface of the BG grain and electrophoresis deposition (EPD), and then a bioactive graded ceramic coating was obtained after sintering of the coating. This technique is a new method for making bioactive graded coating. The adhesive strength between the coating and the substrate reaches 18?MPa, and the better electrophoresis depositing parameters and optimal sintering procedure are obtained.

关键词： hydroxyapatite bioglass electrophoresis deposition graded coating titanium alloy

Chronology of Bioactive Glass Development and Clinical Applications

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New Journal of Glass and Ceramics 2013年第2期3卷 67-73页

作者： Larry L. Hench Department of Materials Science and Engineering University of Florida Gainesville USA.

The key research and development steps for bioactive glass (45S5 bioglass) are documented from the date of discovery in 1969 through FDA approvals of the first dental, ENT, maxillo-facial and orthopedic clinical products. Understanding the mechanisms and quantifying the rapid surface reactions to form a bone-bonding hydroxyl-carbonate apatite (HCA) layer on the bioactive glass in contact with living bone was a vital part of the early development of this class of biomaterials. A key later discovery was enhanced osteogenesis and in situ bone regeneration by controlled release of ionic dissolution products from the bioactive glass particulates that leads to up-regulation and activation of seven families of genes, a process called osteostimulation.

关键词： Bioactive Glass 45S5 bioglass Hydroxyl-Carbonate Apatite (HCA) Bone-Bonding Osteogenesis Regeneration Genes Dental ENT Maxillo-Facial Orthopedics Clinical Osteostimulation