Chronology of Bioactive Glass Development and Clinical Applications
Chronology of Bioactive Glass Development and Clinical Applications作者机构：Department of Materials Science and Engineering University of Florida Gainesville USA.
出 版 物：《New Journal of Glass and Ceramics》 (玻璃与陶瓷期刊（英文）)
年 卷 期：2013年第3卷第2期
页 面：67-73页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Bioactive Glass 45S5 Bioglass Hydroxyl-Carbonate Apatite (HCA) Bone-Bonding Osteogenesis Regeneration Genes Dental ENT Maxillo-Facial Orthopedics Clinical Osteostimulation
摘 要：The key research and development steps for bioactive glass (45S5 Bioglass) are documented from the date of discovery in 1969 through FDA approvals of the first dental, ENT, maxillo-facial and orthopedic clinical products. Understanding the mechanisms and quantifying the rapid surface reactions to form a bone-bonding hydroxyl-carbonate apatite (HCA) layer on the bioactive glass in contact with living bone was a vital part of the early development of this class of biomaterials. A key later discovery was enhanced osteogenesis and in situ bone regeneration by controlled release of ionic dissolution products from the bioactive glass particulates that leads to up-regulation and activation of seven families of genes, a process called osteostimulation.
维普期刊数据库