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biodegradable materials for bone defect repair

Military Medical Research 2021年第2期8卷 202-229页

作者： Shuai Wei Jian-Xiong Ma Lai Xu Xiao-Song Gu Xin-Long Ma Tianjin Hospital Tianjin UniversityTianjin 300211China Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Key Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationNantong UniversityNantongJiangsu 226001China

Compared with non-degradable materials,biodegradable biomaterials play an increasingly important role in the repairing of severe bone defects,and have attracted extensive attention from researchers.In the treatment of bone defects,scaffolds made of biodegradable materials can provide a crawling bridge for new bone tissue in the gap and a platform for cells and growth factors to play a physiological role,which will eventually be degraded and absorbed in the body and be replaced by the new bone tissue.Traditional biodegradable materials include polymers,ceramics and metals,which have been used in bone defect repairing for many years.Although these materials have more or fewer shortcomings,they are still the cornerstone of our development of a new generation of degradable materials.With the rapid development of modern science and technology,in the 21 st century,more and more kinds of new biodegradable materials emerge in endlessly,such as new intelligent micro-nano materials and cell-based products.At the same time,there are many new fabrication technologies of improving biodegradable materials,such as modular fabrication,3 D and 4 D printing,interface reinforcement and nanotechnology.This review will introduce various kinds of biodegradable materials commonly used in bone defect repairing,especially the newly emerging materials and their fabrication technology in recent years,and look forward to the future research direction,hoping to provide researchers in the field with some inspiration and reference.

关键词： biodegradable materials Bone defects Bone repair Intelligent material Modular fabrication

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Recent progress on biodegradable materials and transient electronics

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Bioactive materials 2018年第3期3卷 322-333页

作者： Rongfeng Li Liu Wang Deying Kong Lan Yin School of materials Science and Engineering Tsinghua UniversityBeijing 100084 China

Transient electronics(or biodegradable electronics)is an emerging technology whose key characteristic is an ability to dissolve,resorb,or physically disappear in physiological environments in a controlled manner.Potential applications include eco-friendly sensors,temporary biomedical implants,and datasecure hardware.biodegradable electronics built with water-soluble,biocompatible active and passive materials can provide multifunctional operations for diagnostic and therapeutic purposes,such as monitoring intracranial pressure,identifying neural networks,assisting wound healing process,etc.This review summarizes the up-to-date materials strategies,manufacturing schemes,and device layouts for biodegradable electronics,and the outlook is discussed at the end.It is expected that the translation of these materials and technologies into clinical settings could potentially provide vital tools that are beneficial for human healthcare.

关键词： biodegradable electronics Transient electronics biodegradable materials Silicon Metals

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A review on biodegradable materials for cardiovascular stent application

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Frontiers of materials Science 2016年第3期10卷 238-259页

作者： Li-Da HOU Zhen LI Yu PAN Muhammadlqbal SABIR Yu-Feng ZHENG Li LI Center for Biomedical materials and Engineering Harbin Engineering University Harbin 150001 China Institute of materials Processing and Intelligent Manufacturing Harbin Engineering University Harbin 150001 China Department of materials Science and Engineering College of Engineering Peking University Beijing 100871 China

A stent is a medical device designed to serve as a temporary or permanent internal scaffold to maintain or increase the lumen of a body conduit. The researcher;~ and engineers diverted to investigate biodegradable materials due to the limitation of metallic materials in stent application such as stent restenosis which requires prolonged anti platelet therapy, often result in smaller lumen after implantation and obstruct re-stenting treatments. Biomedical implants with temporary function for the vascular intervention are extensively studied in recent years. The rationale for biodegradable stent is to provide the support for the vessel in predicted period of time and then degrading into biocompatible constituent. The degradation of stent makes the re-stenting possible after several months and also ameliorates the vessel wall quality. The present article focuses on the biodegradable materials for the cardiovascular stent. The objective of this review is to describe the possible biodegradable materials for stent and their properties such as design criteria, degradation behavior, drawbacks and advantages with their recent clinical and preclinical trials.

关键词： biodegradable materials magnesium alloy polymers biodegradablestent cardiovascular stent

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Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys: A review

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Journal of Magnesium and Alloys 2023年第9期11卷 3038-3058页

作者： Chowdhury Ahmed Shahed Faiz Ahmad Ebru Günister Farhana Mohd Foudzi Saad Ali Khurshid Malik Wan Sharuzi Wan Harun Department of Mechanical Engineering Universiti Teknologi PETRONAS(UTP)32610Seri IskandarPerakMalaysia Faculty of Engineering and Natural Sciences Department of Mechanical EngineeringIstanbul Health and Technology UniversityIstanbulTurkey Department of Mechanical and Manufacturing Engineering Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia43600 UKM BangiSelangorMalaysia Faculty of Mechanical&Automotive Engineering Technology Universiti Malaysia Pahang26600 PekanPahangMalaysia

Benefits achieved by the biodegradable magnesium(Mg) and zinc(Zn) implants could be suppressed due to the invasion of infectious microbial, common bacteria, and fungi. Postoperative medications and the antibacterial properties of pure Mg and Zn are insufficient against biofilm and antibiotic-resistant bacteria, bringing osteomyelitis, necrosis, and even death. This study evaluates the antibacterial performance of biodegradable Mg and Zn alloys of different reinforcements, including silver(Ag), copper(Cu), lithium(Li), and gallium(Ga). Copper ions(Cu^(2+)) can eradicate biofilms and antibiotic-resistant bacteria by extracting electrons from the cellular structure. Silver ion(Ag^(+)) kills bacteria by creating bonds with the thiol group. Gallium ion(Ga^(3+)) inhibits ferric ion(Fe^(3+)) absorption, leading to nutrient deficiency and bacterial death. Nanoparticles and reactive oxygen species(ROS) can penetrate bacteria cell walls directly, develop bonds with receptors, and damage nucleotides. Antibacterial action depends on the alkali nature of metal ions and their degradation rate, which often causes cytotoxicity in living cells. Therefore, this review emphasizes the insight into degradation rate, antibacterial mechanism, and their consequent cytotoxicity and observes the correlation between antibacterial performance and oxidation number of metal ions.

关键词： biodegradable materials Biomedical implants Antibacterial mechanism Cytotoxicity Reactive oxygen species

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Characterization of Potential Cellulose from Hylocereus Polyrhizus(Dragon Fruit)peel:A Study on Physicochemical and Thermal Properties

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Journal of Renewable materials 2023年第1期11卷 131-145页

作者： Nurul Hanan Taharuddin Ridhwan Jumaidin Muhd Ridzuan Mansor Fahmi Asyadi Md Yusof Roziela Hanim Alamjuri Fakulti Kejuruteraan Mekanikal Universiti Teknikal Malaysia MelakaHang Tuah JayaMelakaMalaysia Fakulti Teknologi Kejuruteraan Mekanikal dan Pembuatan Universiti Teknikal Malaysia MelakaHang Tuah JayaMelakaMalaysia UNIKL MICET Taboh NaningAlor GajahMelakaMalaysia Faculty of Tropical Forestry Universiti Malaysia SabahJalan UMSSabahMalaysia

The strict environmental regulations to overcome the drawbacks of consumption and disposal of non-renewable synthetic materials have motivated this investigation.The physical,chemical,morphological,and thermal properties of Hylocereus Polyrhizus peel(HPP)powder obtained from the raw materials were examined in this study.The physical properties analyzes of Hylocereus Polyrhizus peel(HPP)powder discovered that the moisture content,density,and water holding capacity were 9.70%,0.45 g/cm^(3),and 98.60%,respectively.Meanwhile,the chemical composition analysis of Hylocereus Polyrhizus peel(HPP)powder revealed that the powder was significantly high in cellulose contents(34.35%)from other bio-peel wastes.The crystallinity index of Hylocereus Polyrhizus peel(HPP)powder was 32.76%,according to further X-ray diffraction(XRD)analysis.The thermal stability of Hylocereus Polyrhizus peel(HPP)powder was examined using thermogravimetric analysis(TGA)and found thermally stable at 204℃.The morphological study via scanning electron microscopy(SEM)showed a shriveled and irregular geometry surface.Hylocereus Polyrhizus peel(HPP)powder demonstrated the peak in the range representing the major functional groups responsible for pectin’s properties.Thus,the findings revealed that the Hylocereus Polyrhizus peel(HPP)powder has the potential for the development of biodegradable and renewable materials.

关键词： Hylocereus Polyrhizus dragon fruit peel natural fiber biodegradable materials

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biodegradable zinc-iron alloys: Complex study of corrosion behavior,mechanical properties and hemocompatibility

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Progress in Natural Science:materials International 2021年第2期31卷 279-287页

作者： Z.Orságová Králová R.Gorejová R.Orin?aková M.Petra?ková A.Orin?ak M.Kupková M.Hrubov?a?ková T.Sop?ák M.Baláz? I.Maska?ová A.Kovalc?íková K.Kova? Department of Physical Chemistry Faculty of Science Pavol Jozef ?afa?rik University in Ko?ice Institute of materials Research Slovak Academy of Sciences Institute of Geotechnics Slovak Academy of Sciences University of Veterinary Medicine and Pharmacy in Ko?ice Department of Animal Nutrition Dietetics and Animal Breeding

Zn-Fe alloys have been extensively investigated in this study with a view to their application as biodegradable bone implants. Biogenic element zinc is a very appropriate metal because of the ideal degradation rate compared to those of Mg and Fe. Studied alloys were made by compressing metallic powders in a content ratio of 100% Zn,Zn-1% Fe, Zn-2% Fe, Zn-5% Fe and Zn-10% Fe and sintering at 350°C for 1 h. Prepared samples were examined by optical microscopy, SEM and XRD. Corrosion behavior, mechanical testing and hemocompatibility were observed subsequently. The electrochemical performance of such materials was studied in the simulated body fluids. The enhanced corrosion rate was observed for all samples after iron addition due to the micro-galvanic effect between the pure Zn and Zn;Fe intermetallic phase. The corrosion rate of the Zn-5% Fe alloyed sample was more than 20-times higher（2.89 mmpy） compared to the pure Zn. However, alloying with more than 5 wt %of iron diminished the mechanical performance of the material. Therefore, the performed mechanical and hemocompatibility tests showed acceptable biocompatibility of zinc and Zn-1% Fe and Zn-2% Fe samples.

关键词： biodegradable materials Zinc Iron Alloy Corrosion behavior Hemocompatibility

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Magnesium as biodegradable Implant Material

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特种铸造及有色合金 2008年第S1期28卷 213-215页

作者： Wang Hao1,2 Shi Zhiming2 Yang Ke3 (1.Faculty of Engineering and Surveying, University of Southern Queensland2.School of Engineering, The University of Queensland3.Institute of Metal Research, Chinese Academy of Sciences)

Drawbacks associated with permanent metallic implants lead to the search for degradable metallic biomaterials. Magnesium alloys have been highly considered as Mg has a high biocorrosion potential and is essential to bodies. In this study, corrosion behaviour of pure magnesium and magnesium alloy AZ31 in both static and dynamic physiological conditions (Hank's solution) has been investigated. It is found that the materials degrade fast at beginning, then stabilize after 5 days of immersion. High purity in the materials reduces the corrosion rate while the dynamic condition accelerates the degradation process. In order to slow down the degradation process to meet the requirement for their bio-applications, an anodized coating is applied and is proved as effective in controlling the biodegradation rate.

关键词： biodegradable materials biomaterials magnesium alloys biocorrosion behaviour.

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Biomaterials for spinal cord repair

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Neuroscience Bulletin 2013年第4期29卷 445-459页

作者： Agnes E. Haggerty Martin oudega Departments of Bioengineering University of Pittsburgh Departments of the Center for the Neural Basis of Cognition University of Pittsburgh Departments of Physical Medicine and Rehabilitation University of Pittsburgh Departments of Neurobiology University of Pittsburgh

Spinal cord injury （SCI） results in permanent loss of function leading to often devastating personal, economic and social problems. A contributing factor to the permanence of SCI is that damaged axons do not regenerate, which prevents the re-establishment of axonal circuits involved in function. Many groups are working to develop treatments that address the lack of axon regeneration after SCI. The emergence of biomaterials for regeneration and increased collaboration between engineers, basic and translational scientists, and clinicians hold promise for the development of effective therapies for SCI. A plethora of biomaterials is available and has been tested in various models of SCI. Considering the clinical relevance of contusion injuries, we primarily focus on polymers that meet the specific criteria for addressing this type of injury. Biomaterials may provide structural support and/or serve as a delivery vehicle for factors to arrest growth inhibition and promote axonal growth. Designing materials to address the specific needs of the damaged central nervous system is crucial and possible with current technology. Here, we review the most prominent materials, their optimal characteristics, and their potential roles in repairing and regenerating damaged axons following SCI.

关键词： spinal cord injury axon regeneration biodegradable materials extracellular matrix proteins functionalrecovery growth factor guidance injury and repair spinal motor neuron

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Biodegradation of Mg-14Li alloy in simulated body fluid: A proof-of-concept study

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Bioactive materials 2018年第1期3卷 110-117页

作者： Xiao-Bo Chen Chuanqiang Li Daokui Xu School of Engineering College of ScienceEngineering and HealthRMIT UniversityCarltonVIC 3053Australia Department of materials Science and Engineering Monash UniversityClayton3800VICAustralia Key Laboratory of Nuclear materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Key Laboratory for Anisotropy and Texture of materials(Ministry of Education) Northeastern UniversityShenyang110819China

High corrosion kinetics and localised corrosion progress are the primary concerns arising from the clinical implementation of magnesium(Mg)based implantable devices.In this study,a binary Mglithium(Li)alloy consisting a record high Li content of 14%(in weight)was employed as model material aiming to yield homogenous and slow corrosion behaviour in a simulated body fluid,i.***.minimum essential medium(MEM),in comparison to that of generic Mg alloy AZ31 and biocompatible Mg-0.5Zn-0.5Ca counterparts.Scanning electron microscopy examination reveals single-phase microstructural characteristics of Mg-14Li(b-Li),whilst the presence of insoluble phases,cathodic to a-Mg matrix,in AZ31 and Mg-0.5Zn-0.5Ca.Though slight differences exist in the corrosion kinetics of all the specimens over a short-term time scale(no longer than 60 min),as indicated by potentiodynamic polarisation and electrochemical impedance spectroscopy,profound variations are apparent in terms of immersion tests,i.***.mass loss and hydrogen evolution measurements(up to 7 days).Cross-sectional micrographs unveil severe pitting corrosion in AZ31 and Mg-0.5Zn-0.5Ca,but not the case for Mg-14Li.X-ray diffraction patterns and X-ray photoelectron spectroscopy confirm that a compact film(25 mm in thickness)consisting of lithium carbonate(Li2CO3)and calcium hydroxide was generated on the surface of Mg-14Li in MEM,which contributes greatly to its low corrosion rate.It is proposed therefore that the single-phase structure and formation of protective and defect-free Li2CO3 film give rise to the controlled and homogenous corrosion behaviour of Mg-14Li in MEM,providing new insights for the exploration of biodegradable Mg materials.

关键词： biodegradable materials Magnesium-lithium alloys MEM SEM Potentiodynamic polarisation

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Engineering nanoparticles to overcome immunological barriers for enhanced drug delivery

再生工程(英文)

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再生工程(英文) 2020年第1期1卷 35-50页

作者： Thomas Malachowski Austin Hassel Department of Biomedical Engineering Stony Brook UniversityUnited States

Nanotechnology has recently gained traction in the medical field as a method of targeted delivery and timed release of therapeutic drugs.As interest in this field grows,design considerations of the selected nanotechnology and extensive knowledge of the human immune system are necessary to design an effective system for drug delivery.Suppression and control of an immune response has become an achievable outcome to ensure efficient treatment of target tissues through careful selection of materials and immune antagonists.This review outlines the immune system,the challenges created by its inherent functions,biocompatible materials that are presently being used to construct nanoparticles,and molecules and techniques used to manipulate the immune response to nanoparticles.

关键词： Immunomanipulation Inflammation Nanoparticle cloaking biodegradable materials Immune responses

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