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bacterial melanin promotes recovery after sciatic nerve injury in rats

Neural Regeneration Research 2015年第1期10卷 124-127页

作者： Olga.V.Gevorkyan Irina B.Meliksetyan Tigran R.Petrosyan Anichka S.Hovsepyan Institute of Physiology National Academy of Sciences of Armenia Department of Kinesiology Armenian State Institute of Physical Culture Scientific and Production Center "Armbiotechnology" National Academy of Sciences of Armenia

bacterial melanin, obtained from the mutant strain of Bacillus Thuringiensis, has been shown to promote recovery after central nervous system injury. It is hypothesized, in this study, that bacterial melanin can promote structural and functional recovery after peripheral nerve injury. Rats subjected to sciatic nerve transection were intramuscularly administered bacterial melanin. The sciatic nerve transected rats that did not receive intramuscular administration of bacterial melanin served as controls. Behavior tests showed that compared to control rats, the time taken for instrumental conditioned reflex recovery was significantly shorter and the ability to keep the balance on the rotating bar was significantly better in bacterial melanin-treated rats. Histomor- phological tests showed that bacterial melanin promoted axon regeneration after sciatic nerve injury. These findings suggest that bacterial melanin exhibits neuroprotective effects on injured sciatic nerve, contributes to limb motor function recovery, and therefore can be used for rehabil- itation treatment of peripheral nerve injury.

关键词： nerve regeneration peripheral nerve injury sciatic nerve injury bacterial melanin motor function histomorphology behaviors neural regeneration

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Detection of Ca^(2+)-dependent acid phosphatase activity identifies neuronal integrity in damaged rat central nervous system after application of bacterial melanin

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Neural Regeneration Research 2016年第7期11卷 1147-1152页

作者： Tigran R. Petrosyan Anna S. Ter-Markosyan Anna S. Hovsepyan Yerevan State Medical University YerevanArmenia SPC"Armbiotechnology"SNPO NAS RA YerevanArmenia

The study aims to confirm the neuroregenerative effects of bacterial melanin （BM） on central nervous system injury using a special staining method based on the detection of Ca^2＋-dependent acid phosphatase activity. Twenty-four rats were randomly assigned to undergo either unilateral destruction of sensorimotor cortex （group I; n = 12） or unilateral rubrospinal tract transection at the cervical level （C3-4）（group II; n = 12）. In each group, six rats were randomly selected after surgery to undergo intramuscular injection of BM solution （BM subgroup） and the remaining six rats were intramuscularly in）ected with saline （saline subgroup）. Neurological testing confirmed that BM accelerated the recovery of motor function in rats from both BM and saline subgroups. Two months after surgery, Ca^2＋-dependent acid phosphatase activity detection in combination with Chilingarian＇s calcium adenoside triphosphate method revealed that BM stimulated the sprouting of fibers and dilated the capillaries in the brain and spinal cord. These results suggest that BM can promote the recovery of motor function of rats with central nervous system injury; and detection of Ca^2＋-dependent acid phosphatase activity is a fast and easy method used to study the regeneration-promoting effects of BM on the injured central nervous system.

关键词： nerve regeneration bacterial melanin histochemical analysis rubrospinal tract sensorimotor cortex Ca^2+-dependent acid phosphatase activity rats neural regeneration

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