Bacterial melanin promotes recovery after sciatic nerve injury in rats

作     者：Olga.V.Gevorkyan Irina B.Meliksetyan Tigran R.Petrosyan Anichka S.Hovsepyan 

作者机构：Institute of PhysiologyNational Academy of Sciences of Armenia Department of KinesiologyArmenian State Institute of Physical Culture Scientific and Production Center "Armbiotechnology" National Academy of Sciences of Armenia 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第1期

页      面：124-127页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：nerve regeneration peripheral nerve injury sciatic nerve injury bacterial melanin motor function histomorphology behaviors neural regeneration 

摘      要：Bacterial melanin, obtained from the mutant strain of Bacillus Thuringiensis, has been shown to promote recovery after central nervous system injury. It is hypothesized, in this study, that bacterial melanin can promote structural and functional recovery after peripheral nerve injury. Rats subjected to sciatic nerve transection were intramuscularly administered bacterial melanin. The sciatic nerve transected rats that did not receive intramuscular administration of bacterial melanin served as controls. Behavior tests showed that compared to control rats, the time taken for instrumental conditioned reflex recovery was significantly shorter and the ability to keep the balance on the rotating bar was significantly better in bacterial melanin-treated rats. Histomor- phological tests showed that bacterial melanin promoted axon regeneration after sciatic nerve injury. These findings suggest that bacterial melanin exhibits neuroprotective effects on injured sciatic nerve, contributes to limb motor function recovery, and therefore can be used for rehabil- itation treatment of peripheral nerve injury.