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Expression levels of ROS and Atg proteins in the vitreous in rhegmatogenous retinal detachment

International Journal of Ophthalmology(English edition) 2023年第3期16卷 348-353页

作者： Nan Huang Xue-Yan Gao Jin-Ping Li Xing Lu Hua-Mei Zhu Kai Dong Department of Ophthalmology Xiaoxian People’s HospitalSuzhou 234000Anhui ProvinceChina Graduate School of Bengbu Medical College Bengbu233000Anhui ProvinceChina Department of Ophthalmology Eye Centerthe First AffiliatedHospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Graduate School of Anhui Medical University Hefei 230001Anhui ProvinceChina Hefei Aier Eye Hospital Hefei 230001Anhui ProvinceChina

AIM:To detect the concentrations of reactive oxygen species(ROS),transient receptor potential mucin-1(TRPML1),and autophagy-related(Atg)proteins(LC3-Ⅰ,LC3-Ⅱ,and Beclin1)in vitreous humor of patients with simple rhegmatogenous retinal detachment(RRD).METHODS:RRD patients enrolled as the RRD group,and patients with idiopathic macular hole(IMH)and idiopathic macular epiretinal membrane(IMEM)were enrolled as control *** levels of ROS,TRPML1,LC3-Ⅰ,LC3-Ⅱ,and Beclin1 in vitreous humor of patients in the RRD and control groups were detected by enzyme-linked immunosorbent assay(ELISA).RESULTS:The RRD group included 28 eyes 28 patients and had a higher concentration of ROS in vitreous humor(631.86±18.05 vs 436.34±108.22 IU/m L,Prelated with RD time(r=-0.46,P=0.01).The expression levels of LC3-Ⅰand Beclin1 significantly decreased in RRD(Pproteins decrease,reflecting possibly that autophagy is inhibited.

关键词： autophagy-related proteins reactive oxygen species vitreous body retinal detachment

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Acetyl-L-carnitine protects adipose-derived stem cells exposed to H2O2 through regulating AMBRA1-related autophagy

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BIOCELL 2021年第1期45卷 189-198页

作者： YAO QIAN JINGPING WANG ZIWAN JI HAO CHEN YUCANG HE XULING LV ZIKAI ZHANG TIAN LI TIANYUN PAN LIQUN LI MING LIN The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Wenzhou325000China The First Affiliated Hospital of Wenzhou Medical University Wenzhou325000China Huzhou Hospital of Traditional Chinese Medicine Huzhou313000China

The cell activity of adipose-derived stem cells(ADSCs)is affected by the intracellular reactive oxygen species(ROS)and the level of *** studies reveal that acetyl-L-carnitine(ALC)possesses capacities of resisting oxidative stress and regulating *** molecule in Beclin1-regulated autophagy protein 1(AMBRA1)plays a key role in initiating Beclin1-regulated *** the present study,we discovered ALC pretreatment(1 mM,24 h)significantly increased the activity of ADSCs exposed to H_(2)O_(2)(100μM,2 h)in vitro with improved stemness,and reduced the production of intracellular *** addition,we found for the first time that ALC treatment up-regulated autophagy of ADSCs through strengthening the expressions of Beclin1 and AMBRA1 synchronously,which might be involved in the protective effect of ALC.

关键词： Oxidative stress Cell activity autophagy-related proteins Antioxidant enzymes

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