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Immunization with autologous t cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45β

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Cell Research 2006年第8期16卷 702-712页

作者： Li Wang~(1,2,*) Fang Du~(1,2,*) Qi Cao~(1,2) Huiming Sheng~(1,2) Baihua Shen~(1,2) Yan Zhang~(1,2) Yingna Diao~(1,2) Jingwu Zhang~(1,2) Ningli Li~(1,2) ~1Shanghai diao tong UniversiO,School of Medicine,280 Chongqing Road,Shanghai 200025,China ~2Shanghai Institute of Immunology,280 Chongqing Road,Shanghai 200025,China Shanghai Jiao tong University School of Medicine Shanghai China Shanghai Institute of Immunology Shanghai China

Immunization with inactivated autoreactive t cells may induce idiotype anti-idiotypic reactions to deplete autoreac-tire t cells,which are involved in autoimmune ***,it is unknown whether attenuated activated healthyautologous t-cell immunization could increase anti-tumor immune *** this end,C57B1/6 mice were immunizedwith attenuated activated autologous t *** splenocytes from immunized mice showed a higher proliferative abil-ity than that from naive *** special phenotype analysis showed that there were more CDS+t cells and CD62L+t cells in immunized mice after 24 h of culture with 10% fetal calf serum complete medium in vitro(Ptheseresults demonstrated that this immunization may activate t cells in ***,the splenocytes from immunizedmice revealed resistance to activation-induced cell death(AICD)in *** further study the relative genes that areresponsible for the higher proliferation and resistance to AICD,the expression of Fas/Fas ligand(FasL)and GADD45βwas measured by real-time *** results indicated that GADD45β transcription was higher in the splenocytes fromimmunized mice than that in the naive *** addition,the Fas expression showed a parallel higher,but FasL did notchange *** investigate the biologic functions induced by immunization in vivo,a tumor model was establishedby EL-4 tumor cell inoculation in C57/B1 *** receiving autologous t-cell immunization had significantly inhibitedtumor growth in vivo(Pthis study implicated that immunization with attenuated activated autologous t cellsenhances anti-tumor immune responses that participate in tumor growth inhibition.

关键词： anti-tumor immunity immunization autologous t cells GADD45β AICD

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