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The effect of acute aerobic exercise on central arterial stiffness,wave reflections,and hemodynamics in adults with diabetes:A randomized cross-over design

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Journal of Sport and Health Science 2021年第4期10卷 499-506页

作者： Kimberley L.Way Angela S.Lee Stephen M.Twigg Nathan A.Johnson Faculty of Medicine and Health Discipline of Exercise and Sports ScienceUniversity of SydneyLidcombeNSW 2141Australia Charles Perkins Centre University of SydneyCamperdownNSW 2006Australia Boden Collaboration for Obesity NutritionExercise and Eating DisordersUniversity of SydneyCamperdownNSW 2006Australia Faculty of Medicine and Health Central Clinical SchoolUniversity of SydneyCamperdownNSW 2006Australia Department of Endocrinology Diabetes CentreRoyal Prince Alfred HospitalSydneyNSW 2050Australia

Background:Individuals with diabetes have greater central arterial stiffness,wave reflections,and hemodynamics,all of which promote the accelerated cardiovascular pathology seen in this *** aerobic exercise has been shown to be an effective strategy for reducing central arterial stiffness,wave reflections,and hemodynamics in healthy individuals;however,the effects of acute aerobic exercise in reducing these outcomes is not well established in people with ***,implementation of high-intensity interval exercise(HIIE)has shown superior improvements in cardiovascular health outcomes when compared to traditional aerobic ***,the effect of HIIE on the aforementioned outcomes in people with diabetes is not *** purpose of this study was to(i)describe the central arterial stiffness,wave reflections,and hemodynamic responses to a bout of HIIE and moderate-intensity continuous exercise(MICE)in adults with diabetes;and(ii)compare the effects of HIIE and MICE on the aforementioned ***:A total of 24 adult men and women(aged 29-59 years old)with type 1(n=12)and type 2(n=12)diabetes participated in a randomized cross-over *** participants completed the following protocols:(i)HIIE:cycling for 4×4 min at 85%-95%of heart rate peak(HR_(peak)),interspersed with 3 min of active recovery at 60%-70%HR_(peak);(ii)MICE:33 min of continuous cycling at 60%-70%HR_(peak);and(iii)control(CON):lying quietly in a supine position for 30 ***:A significant group￡time effect was found for changes in central systolic blood pressure(F=3.20,p=0.01)with a transient reduction for the HIIE group but not for the MICE or CON *** was a significant group￡time effect for changes in augmentation index at a heart rate of 75 beats/min(F=2.32,p=0.04)with a decrease following for HIIE and MICE but not for *** all other measures of central arterial stiffness and hemodynamics,no significant changes were observed(p>0.05).Conclusion:A bout of

关键词： augmentation index Central systolic blood pressure Diabetes High-intensity interval exercise

Influence of cardiorespiratory fitness and body composition on resting and post-exercise indices of vascular health in young adults

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Sports Medicine and Health Science 2024年第1期6卷 54-62页

作者： Rian Q.Landers-Ramos Kathleen Dondero Ian Imery Nicholas Reveille Hannah A.Zabriskie Devon A.Dobrosielski Towson University Department of KinesiologyTowsonMDUSA University of Maryland School of Medicine Department of Physical Therapy and Rehabilitation SciencesBaltimoreMDUSA Johns Hopkins University Department of Cell BiologyBaltimoreMDUSA University of Florida Department of Applied Physiology and KinesiologyGainesvilleFLUSA

Poor cardiorespiratory fitness may mediate vascular impairments at rest and following an acute bout of exercise in young healthy *** study aimed to compare flow mediated dilation(FMD)and vascular augmentation index(AIx75)between young adults with low,moderate,and high levels of cardiorespiratory fitness before and after an acute bout of aerobic ***-three participants(22 men;21 women)between 18 and 29 years of age completed the *** were classified into low,moderate,and high health-related cardiorespiratory fitness groups according to age-and sex-based relative maximal oxygen consumption(V_O2 max)percentile *** was performed using Doppler ultrasound and AIx75 was performed using pulse wave analysis at baseline and 60-min after a 30-min bout of treadmill running at 70%V_O2 max.A significant interaction(p=0.047;ηp 2=0.142)was observed,with the moderate fitness group exhibiting a higher FMD post-exercise compared with baseline([6.7%3.1%]vs.[8.5%2.8%],p=0.028;d=0.598).We found a significant main effect of group for AIx75(p=0.023;ηp 2=0.168),with the high fitness group exhibiting lower AIx75 compared to low fitness group([10%10%]vs.[2%10%],respectively,p=0.019;g=1.07).This was eliminated after covarying for body fat percentage(p=0.489).Our findings suggest that resting FMD and AIx75 responses are not significantly influenced by cardiorespiratory fitness,but FMD recovery responses to exercise may be enhanced in individuals with moderate cardiorespiratory fitness levels.

关键词： Cardiorespiratory fitness Flow mediated dilation augmentation index Vascular Acute exercise Body composition

Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function

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Journal of Geriatric Cardiology 2012年第2期9卷 158-165页

作者： Su-Yan Bian Hong-Yang Guo Ping Ye Lei-Ming Luo Hong-Mei Wu Wen-Kai Xiao Li-PingQi He-Peng Yu Liu-Fa Duan The Second Department of Geriatric Cardiology Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China Departmen of Cardiology Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China

Objective Both decreased glomemlar filtration rate （GFR） and arterial stiffness were considered as risk factors for atherosclerosis. Previous studies have suggested the association between central arterial stiffness and the degree of GFR loss. Whether decreased GFR contributes to peripheral artery stiffness remains controversial. Moreover, data analyzed from a cohort of Chinese women are rare. Our aim was to explore the relationship between GFR and regional arterial stiffness in Chinese women. Methods In this cross-sectional study, we randomly recruited 1131 adult women residents with GFR 〉 60 mL/min per 1.73 m2 estimated by the Chinese Modification of Diet in Renal Disease equation from three large communities. Central and peripheral arterial stiffness were estimated simultaneously by measuring carotid-femoral pulse wave velocity （PWVcf） and carotid-radial PWV （PWVcr） using a validated automatic device. augmentation index at heart rate 75 beats/minutes （AIx-75） was measured by pulse wave analysis as a composite parameter reflecting both large and distal arterial properties. Results The mean estimated GFR （eGFR） of the study group was 100.05 ＋ 23.26 mL/minute per 1.73 m2. Subjects were grouped by tertiles of eGFR level. PWVef and AIx-75 increased ongoing from the top to the bottom eGFR tertile, while the values of PWVcr were comparable. Both univariate Pearson correlations and multiple stepwise regression analyses showed that eGFR significantly correlated to PWVcf, but not to PWVcr and AJx-75. Conclusions In Chinese women with normal to mildly impaired renal function, decreased eGFR affected carotid-to-femoral rather than carotid-to-radial stiffening. This provides rational to conduct future prospective studies to investigate predictors of atherosclerosis in this population.

关键词： Arterial stiffness augmentation index Pulse wave velocity Glomerular filtration rate Chinese women

Non-invasive cuffless blood pressure and heart rate monitoring using impedance cardiography

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Intelligent Medicine 2022年第4期2卷 199-208页

作者： Sudipta Ghosh Bhabani Prasad Chattopadhyay Ram Mohan Roy Jayanta Mukherjee Manjunatha Mahadevappa Department of Computer Science&Engineering Indian Institute of Technology KharagpurKharagpurWest Bengal 721302India School of Medical Science&Technology Indian Institute of Technology KharagpurKharagpurWest Bengal 721302India Department of Cardiology Medical College&HospitalKolkataWest Bengal 700073India

Background Continuous blood pressure(BP)monitoring provides additional information about how changes in BP may correlate with daily activities and sleep *** from the American Heart Association and American College of Cardiology strongly suggest confirming a diagnosis of hypertension with continuous BP ***-invasive and non-intrusive detection of haemodynamic parameters is emerging as a norm,based on self-monitoring wearable medical *** have carried out several studies using non-invasive and continuous BP measurements as an alternative to conventional cuff-based *** this work,we proposed a novel method for cuffless estimation of BP using impedance cardiography(ICG).Methods We conducted a single-centre,cross-sectional study of 104 subjects(of whom 30 were categorized as controls and the remaining 74 as the disease group)at the Medical College and Hospital,*** disease group consisted of patients with confirmed coronary artery disease,while the individuals in the control group were deemed to be *** subjects underwent electrocardiogram recording by on-duty doctors in order to determine their health status.A custom-made device based on the principle of impedance plethysmography was designed to record impedance changes due to subjects’peripheral blood *** device was used to record ICG *** this study,we developed a novel auto-adaptive algorithm based on ICG signals for non-invasive,cuffless,continuous monitoring of BP and heart *** mathematical models were developed for all the estimated parameters(BP and heart rate)for both the study groups(control and disease).The developed models were auto-adaptive and did not require subject-specific *** indicators including,𝑟2,error percentage,standard deviation,and mean difference were used to quantify the performance of the *** The ICG signal recorded by the device was used to extract features and compute t

关键词： Impedance cardiography augmentation index Systolic pressure Diastolic pressure Heart rate

Increased Risk of Arterial Stiffness in Rhumatoid Arthritis Patients in a Sub-Saharan African Setting

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World Journal of Cardiovascular Diseases 2023年第6期13卷 313-326页

作者： Asongwed Achu Reid Joshua Njimbuc Walinjom Collins Chenwi Eho Emerentia Achu Achiri Roosevelt Daniel Tchamdeu Jan Rene Nkeck Marie Solange Doualla Daniel Lemogoum Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon Medical Unit Douala General Hospital Douala Cameroon Hô pital Erasme Université Libre de Bruxelles Bruxelles Belgium

Background: Analysis of arterial stiffness (AS) is a good marker of early arterial disease and an important determinant of cardiovascular risk, independent of other traditional cardiovascular risk factors. Carotid-femoral pulse wave velocity (CfPWV) is the gold standard to evaluate arterial stiffness. There is evidence that patients with rheumatoid arthritis (RA) have a higher arterial stiffness than their age-matched healthy counterparts and thus have higher cardiovascular (CV) risk. However, data on arterial stiffness in African rheumatoid arthritis patients is scarce. Objectives: To determine the patterns of arterial stiffness in rheumatoid arthritis patients in a sub-Saharan African setting, using CfPWV and augmentation index (AIx). Method: We conducted a case-control study, at the Douala general hospital over four months (February to May 2018) on 63 subjects among which 31 RA patients matched for age and sex with 32 healthy subjects. AIx and CfPWV were determined non-invasively by radial pulse wave analysis and carotid femoral wave analysis respectively, using a sphygmocor Atcor device (SphygmoCor, PWV Medical, Sydney, Australia). Results: The mean age of RA patients was 47 ± 14 years with most of them being females (n = 26, 83.9%). CfPWV was significantly higher in RA patients compared to the control group (mean: 8.85 ± 2.1 vs 7.45 ± 1.38;p ≤ 0.01) as well as was AIx (Median: 33 [26 - 43] vs 26 [20 - 31];p = 0.01). RA (OR: 6.105;95% CI: 1.52 - 24.54;p 1.34;95% CI: 1.14 - 5.17;p = 0.05), elevated CRP levels (OR: 4.01;95% CI: 1.16 - 13.68;p = 0.03) and Hypertension (OR: 5.75;95% CI: 1.24 -11.60;p Conclusion: Arterial stiffness, a well-recognized marker of cardiovascular risk is increased among patients suffering from rheumatoid arthritis when compared to a healthy control group.

关键词： Rheumatoid Arthritis Arterial Stiffness CfPWV augmentation index

Modulation by anti-oketsu formulations in Kampo medicine of human arterial stiffness

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Traditional Medicine Research 2017年第3期2卷 130-138页

作者： Hiroyasu Satoh Health Life Science Shitennoji UniversityHabikinoOsakaJapan

Objective:In traditional herbal medicine(Kampo medicine in Japan),'sho'is diagnosed by the traditional assessments of clinical *** a variety of the shos,there is an'oketsu'syndrome,which is a stagnation and disturbance of *** prompt effects of four anti-oketsu formulations in Kampo medicine on cardiovascular functions were compared in oketsu and non-oketsu ***:The arterial pulse wave from radial artery is formed by the combination with ejection and reflection *** augmentation index(AI),a ration of the ejection and reflection pulses,indicates a degree of *** both seventy-six students with oketsu and thirty-seven students with non-oketsu,Kampo formulations overcoming oketsu of Tokishakuyakusan(TS,Dang-Gui-Shao-Yao-San),Kamishoyosan(KS,Jia-Wei-Xiao-Yao-San),Keisibukuryogan(KB,Gui-Zhi-Fu-Ling-Wan)and Tokakujokito(TJ,Tao-He-Cheng-Qi-Tang)were taken once,and then,the cardiovascular functions including blood pressure,heart rate,central arterial blood pressure(CBP)and AI were examined for 60 ***:At 40-60 min after an intake,these formulations decreased the AI almost by 6-18%(n=76),by 18.3±3.1%(P<0.01,n=15)with ***,the CBP was reduced by 9.0±1.8%(P<0.05,n=23)with KS and by 9.1±2.0%(P<0.05,n=15)with *** the other hands,non-oketsu group had less or no effect by any kinds of the ***:The anti-oketsu formulations can exert the ameliorative action for oketsu persons via decreasing AI and CBP.

关键词： Kampo medicine Sho Oketsu Disturbances of microcirculation augmentation index Central arterial blood pressure

Albuminuria as a marker of arterial stiffness in chronic kidney disease patients

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World Journal of Nephrology 2015年第3期4卷 406-414页

作者： Rigas G Kalaitzidis Despina P Karasavvidou Athina Tatsioni Kosmas Pappas Giorgos Katatsis Angelos Liontos Moses S Elisaf Outpatient Renal and Hypertension Clinic University Hospital of Ioannina Department of Internal Medicine Medical SchoolUniversity of Ioannina

AIM： To access the association between albuminuria levels and arterial stiffness in non-diabetic patients with hypertension and chronic kidney disease （CKD） stages 1-2, treated with renin angiotensin blockade agents plus other hypertensive drugs when ***： One hundred fifteen patients [median age 52 years （68% males）] were consequently enrolled in the study. For each patient, we recorded gender, age, body mass index （BMI）, peripheral systolic blood pressure （pSBP）, peripheral diastolic blood pressure, peripheral pulse pressure, central systolic blood pressure （cSBP）, central diastolic blood pressure （cDBP）, central pulse pressure （cPP）, hematocrit, hemoglobin, hsCRP, total cholesterol triglycerides, high-density lipoprotein-C, low-density lipoprotein-C, calcium, phosphorus, parathormone, and albumin, as well as 24 h urine albumin excretion. According to 24-h urine albumin collection, patients were then classified as those with moderately increased albuminuria （formerly called macroalbuminuria）（≤ 300 mg/d） and those with severely increased albuminuria （formerly called macroaluminuria （〉 300 mg/d）. We considered aortic stiffness （AS） indices [carotid femoral pulse wave velocity （PWVc-f） and augmentation index （AIx）] as primary outcomes of the study. We explored potential correlations between severely increased albuminuria and AS indices using a multiple linear regression model. RESULTS： Fifty-eight patients were included in the moderately increased albuminuria group and 57 in the severely increased albuminuria. Blood pressure measurements of the study population were 138 ± 14/82 ± 1.3 mmHg （systolic/diastolic）. There were no significant differences in age, sex, and BP measurements between the two groups. Patients with severely increased albuminuria had higher PWV and AIx than patients with moderately increased albuminuria （P 〈 0.02, P 〈 0.004, respectively）. In addition these patients exhibited higher BMI （P 〈 0.03）, hsCRP （P 〈 0.001）, and fibrinogen level

关键词： Arterial stiffness Pulse wave velocity augmentation index Albuminuria